journal article·2025-09

Multifunctional hydroxyapatite-carbon dot nanocomposites grafted with polyglycerol: synthesis, characterization, and application in self-targeted cell imaging and drug delivery

Peijian Yang, Jie Wang, Haiyun Zhai, Xiulan Cai

Journal of Nanoparticle Research· Volume 27· Issue 9
Publisher page

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (57)

Show source-provided references
1. Yao J, Yang M, Duan YX (2014) Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy. Chem Rev 114:6130–617810.1021/cr200359p ↗
2. Sun LD, Wang YF, Yan CH (2014) Paradigms and challenges for bioapplication of rare earth upconversion luminescent nanoparticles: small size and tunable emission/excitation spectra. Accounts Chem Res 47:1001–100910.1021/ar400218t ↗
3. Zhong YL, Sun XT, Wang SY, Peng F, Bao F, Su YY, Li YY, Lee ST, He Y (2015) Facile, large-quantity synthesis of stable, tunable-color silicon nanoparticles and their application for long-term cellular imaging. ACS Nano 9:5958–596710.1021/acsnano.5b00683 ↗
4. Wang ZL, Xu B, Zhang L, Zhang JB, Ma TH, Zhang JB, Fu XQ, Tian WJ (2013) Folic acid-functionalized mesoporous silica nanospheres hybridized with AIE luminogens for targeted cancer cell imaging. Nanoscale 5:2065–207210.1039/c2nr33685e ↗
5. Zhou FY, Feng B, Yu HJ, Wang DG, Wang TT, Liu JP, Meng QS, Wang SL, Zhang PC, Zhang ZW, Li YP (2016) Cisplatin prodrug-conjugated gold nanocluster for fluorescence imaging and targeted therapy of the breast cancer. Theranostics 6:679–68710.7150/thno.14556 ↗
6. Wen DN, Zhang XY, Ding L, Wen H, Liu W, Zhang CW, Wang B, Li LH, Diao HP (2022) Folic acid functionalized aggregation-induced emission nanoparticles for tumor cell targeted imaging and photodynamic therapy. RSC Adv 12:4484–448910.1039/D1RA09173E ↗
7. Zheng XT, Ananthanarayanan A, Luo KQ, Chen P (2015) Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small 11:1620–163610.1002/smll.201402648 ↗
8. Jiang K, Sun S, Zhang L, Lu Y, Wu A, Cai C, Lin H (2015) Red, green, and blue luminescence by carbon dots: full-color emission tuning and multicolor cellular imaging. Angew Chem Int Ed Engl 54:5360–536310.1002/anie.201501193 ↗
9. Ghaffarkhah A, Hosseini E, Kamkar M, Sehat AA, Dordanihaghighi S, Allahbakhsh A, van der Kuur C, Arjmand M (2022) Synthesis, applications, and prospects of graphene quantum dots: a comprehensive review. Small. https://doi.org/10.1002/smll.20210268310.1002/smll.202102683 ↗
10. Zheng M, Ruan S, Liu S, Sun T, Qu D, Zhao H, Xie Z, Gao H, Jing X, Sun Z (2015) Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano 9:11455–1146110.1021/acsnano.5b05575 ↗
11. Bhunia SK, Maity AR, Nandi S, Stepensky D, Jelinek R (2016) Imaging cancer cells expressing the folate receptor with carbon dots produced from folic acid. Chembiochem 17:614–61910.1002/cbic.201500694 ↗
12. Huang YT, Imura M, Nemoto Y, Cheng CH, Yamauchi Y (2011) Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size. Sci Technol Adv Mater. https://doi.org/10.1088/1468-6996/12/4/04500510.1088/1468-6996/12/4/045005 ↗
13. Vecchio KS, Zhang X, Massie JB, Wang M, Kim CW (2007) Conversion of bulk seashells to biocompatible hydroxyapatite for bone implants. Acta Biomater 3:910–91810.1016/j.actbio.2007.06.003 ↗
14. Ma MG (2012) Hierarchically nanostructured hydroxyapatite: hydrothermal synthesis, morphology control, growth mechanism, and biological activity. Int J Nanomed 7:1781–179110.2147/IJN.S29884 ↗
15. Montazeri N, Jahandideh R, Biazar E (2011) Synthesis of fluorapatite-hydroxyapatite nanoparticles and toxicity investigations. Int J Nanomed 6:197–201
16. Fihri A, Len C, Varma RS, Solhy A (2017) Hydroxyapatite: a review of syntheses, structure and applications in heterogeneous catalysis. Coord Chem Rev 347:48–7610.1016/j.ccr.2017.06.009 ↗
17. He J, Zhang K, Wu S, Cai X, Chen K, Li Y, Sun B, Jia Y, Meng F, Jin Z, Kong L, Liu J (2016) Performance of novel hydroxyapatite nanowires in treatment of fluoride contaminated water. J Hazard Mater 303:119–13010.1016/j.jhazmat.2015.10.028 ↗
18. Guillaume O, Geven MA, Sprecher CM, Stadelmann VA, Grijpma DW, Tang TT, Qin L, Lai Y, Alini M, de Bruijn JD, Yuan H, Richards RG, Eglin D (2017) Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair. Acta Biomater 54:386–39810.1016/j.actbio.2017.03.006 ↗
19. Martinez-Vazquez FJ, Cabanas MV, Paris JL, Lozano D, Vallet-Regi M (2015) Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration. Acta Biomater 15:200–20910.1016/j.actbio.2014.12.021 ↗
20. Ma B, Zhang S, Liu R, Qiu J, Zhao L, Wang S, Li J, Sang Y, Jiang H, Liu H (2017) Prolonged fluorescence lifetime of carbon quantum dots by combining with hydroxyapatite nanorods for bio-applications. Nanoscale 9:2162–217110.1039/C6NR05983J ↗
21. Doan VHM, Mondal S, Vo TMT, Ly CD, Vu DD, Nguyen VT, Park S, Choi J, Oh J (2022) Fluorescence conjugated nanostructured cobalt-doped hydroxyapatite platform for imaging-guided drug delivery application. Colloids Surf B Biointerfaces 214:11245810.1016/j.colsurfb.2022.112458 ↗
22. M. Jakubowski, L. Majchrzycki, A. Zarkov, A. Voelkel, M. Sandomierski, Zinc-doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6-mercaptopurine, J Biomed Mater Res B, 112 (2024).10.1002/jbm.b.35395 ↗
23. Lin FH, Hsu YC, Chang KC, Shyong YJ (2023) Porous hydroxyapatite carrier enables localized and sustained delivery of honokiol for glioma treatment. Eur J Pharm Biopharm 189:224–23210.1016/j.ejpb.2023.06.016 ↗
24. Zhao Y, Shi L, Fang J, Feng X (2015) Bio-nanoplatforms based on carbon dots conjugating with F-substituted nano-hydroxyapatite for cellular imaging. Nanoscale 7:20033–2004110.1039/C5NR06837A ↗
25. Zhao L, Takimoto T, Ito M, Kitagawa N, Kimura T, Komatsu N (2011) Chromatographic separation of highly soluble diamond nanoparticles prepared by polyglycerol grafting. Angew Chem Int Ed Engl 50:1388–139210.1002/anie.201006310 ↗
26. Yang X, Wen Y, Wu A, Xu M, Amano T, Zheng L, Zhao L (2017) Polyglycerol mediated covalent construction of magnetic mesoporous silica nanohybrid with aqueous dispersibility for drug delivery. Mater Sci Eng C Mater Biol Appl 80:517–52510.1016/j.msec.2017.06.022 ↗
27. Bej R, Achazi K, Haag R, Ghosh S (2020) Polymersome formation by amphiphilic polyglycerol-b-polydisulfide-b-polyglycerol and glutathione-triggered intracellular drug delivery. Biomacromolecules 21:3353–336310.1021/acs.biomac.0c00775 ↗
28. Yang X, Zhao L, Zheng L, Xu M, Cai X (2018) Polyglycerol grafting and RGD peptide conjugation on MnO nanoclusters for enhanced colloidal stability, selective cellular uptake and cytotoxicity. Colloids Surf B Biointerfaces 163:167–17410.1016/j.colsurfb.2017.12.034 ↗
29. Zhao L, Xu YH, Akasaka T, Abe S, Komatsu N, Watari F, Chen X (2014) Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells. Biomaterials 35:5393–540610.1016/j.biomaterials.2014.03.041 ↗
30. Amoozgar Z, Yeo Y (2012) Recent advances in stealth coating of nanoparticle drug delivery systems. WIREs Nanomed Nanobiotechnol 4:219–23310.1002/wnan.1157 ↗
31. Zhao L, Chano T, Morikawa S, Saito Y, Shiino A, Shimizu S, Maeda T, Irie T, Aonuma S, Okabe H, Kimura T, Inubushi T, Komatsu N (2012) Hyperbranched polyglycerol-grafted superparamagnetic iron oxide nanoparticles: synthesis, characterization, functionalization, size separation, magnetic properties, and biological applications. Adv Funct Mater 22:5107–511710.1002/adfm.201201060 ↗
32. Assadi Z, Emtiazi G, Zarrabi A (2018) Hyperbranched polyglycerol coated on copper oxide nanoparticles as a novel core-shell nano-carrier hydrophilic drug delivery model. J Mol Liq 250:375–38010.1016/j.molliq.2017.12.031 ↗
33. Mu S, Li G, Liang Y, Wu T, Ma D (2017) Hyperbranched polyglycerol-modified graphene oxide as an efficient drug carrier with good biocompatibility. Mater Sci Eng C Mater Biol 78:639–64610.1016/j.msec.2017.04.145 ↗
34. Li S, Guo Z, Feng R, Zhang Y, Xue W, Liu Z (2017) Hyperbranched polyglycerol conjugated fluorescent carbon dots with improved in vitro toxicity and red blood cell compatibility for bioimaging. RSC Adv 7:4975–498210.1039/C6RA27159F ↗
35. Das P, Jana NR (2014) Highly colloidally stable hyperbranched polyglycerol grafted red fluorescent silicon nanoparticle as bioimaging probe. ACS Appl Mater Interfaces 6:4301–430910.1021/am406061x ↗
36. Dubey N, Ramteke S, Jain NK, Dutta T, Koner AL (2022) Folate-receptor-mediated uptake of carbon dots as a pH-responsive carrier for chemotherapy. ChemSelect. https://doi.org/10.1002/slct.20220160410.1002/slct.202201604 ↗
37. Ma X, Zhao Y, Ng KW, Zhao Y (2013) Integrated hollow mesoporous silica nanoparticles for target drug/siRNA co-delivery. Chemistry – A European Journal 19:15593–1560310.1002/chem.201302736 ↗
38. Song Y, Shi W, Chen W, Li X, Ma H (2012) Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells. J Mater Chem 22:12568–1257310.1039/c2jm31582c ↗
39. Ma Z, Ming H, Huang H, Liu Y, Kang Z (2012) One-step ultrasonic synthesis of fluorescent N-doped carbon dots from glucose and their visible-light sensitive photocatalytic ability. New J Chem 36:861–86410.1039/c2nj20942j ↗
40. Li H, He X, Liu Y, Huang H, Lian S, Lee S-T, Kang Z (2011) One-step ultrasonic synthesis of water-soluble carbon nanoparticles with excellent photoluminescent properties. Carbon 49:605–60910.1016/j.carbon.2010.10.004 ↗
41. Shi W, Hatori S, Noda D, Yamada I, Tagaya M (2024) Direct immobilization of folic acid molecules on hydroxyapatite nanoparticles with substitution and coordination phenomena. ACS Biomater Sci Eng 10:6615–662410.1021/acsbiomaterials.4c01146 ↗
42. Xiao DQ, Chi F, Yao N, Zhang CD, Duan K, Weng J (2013) Nanostructured hydroxyapatite microspheres by templated synthesis: formation and mechanisms. Acta Agron Sin 40:935–94710.3724/SP.J.1206.2013.00285 ↗
43. Jiang D, Zhao H, Yang Y, Zhu Y, Chen X, Sun J, Yu K, Fan H, Zhang X (2017) Investigation of luminescent mechanism: N-rich carbon dots as luminescence centers in fluorescent hydroxyapatite prepared using a typical hydrothermal process. J Mater Chem B 5:3749–375710.1039/C6TB03184F ↗
44. Zhu S, Meng Q, Wang L, Zhang J, Song Y, Jin H, Zhang K, Sun H, Wang H, Yang B (2013) Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging. Angew Chem 125:4045–404910.1002/ange.201300519 ↗
45. Wang G, Yang L, Jiang L, Shi M, Wei Z, Zhong W, Li S, Cui J, Wei W (2016) Simple combination of humic acid with biogenic hydroxyapatite achieved highly efficient removal of methylene blue from aqueous solution. RSC Adv 6:67888–6789710.1039/C6RA08715A ↗
46. Morgan H, Wilson R, Elliott J, Dowker S, Anderson P (2000) Preparation and characterisation of monoclinic hydroxyapatite and its precipitated carbonate apatite intermediate. Biomaterials 21:617–62710.1016/S0142-9612(99)00225-2 ↗
47. Wang L, Yin Y, Jain A, Zhou HS (2014) Aqueous phase synthesis of highly luminescent, nitrogen-doped carbon dots and their application as bioimaging agents. Langmuir 30:14270–1427510.1021/la5031813 ↗
48. Lu HB, Campbell CT, Graham DJ, Ratner BD (2000) Surface characterization of hydroxyapatite and related calcium phosphates by XPS and TOF-SIMS. Anal Chem 72:2886–289410.1021/ac990812h ↗
49. Wen XM, Yu P, Toh YR, Hao XT, Tang J (2013) Intrinsic and extrinsic fluorescence in carbon nanodots: ultrafast time-resolved fluorescence and carrier dynamics. Adv Opt Mater 1:173–17810.1002/adom.201200046 ↗
50. Song Y, Zhu S, Xiang S, Zhao X, Zhang J, Zhang H, Fu Y, Yang B (2014) Investigation into the fluorescence quenching behaviors and applications of carbon dots. Nanoscale 6:4676–468210.1039/c4nr00029c ↗
51. Liu H, Li Z, Sun Y, Geng X, Hu Y, Meng H, Ge J, Qu L (2018) Synthesis of luminescent carbon dots with ultrahigh quantum yield and inherent folate receptor-positive cancer cell targetability. Sci Rep 8:108610.1038/s41598-018-19373-3 ↗
52. Yang X, Yang X, Li Z, Li S, Han Y, Chen Y, Bu X, Su C, Xu H, Jiang Y, Lin Q (2015) Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells. J Colloid Interface Sci 456:1–610.1016/j.jcis.2015.06.002 ↗
53. Zhang M, Yuan P, Zhou N, Su Y, Shao M, Chi C (2017) pH-sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research. RSC Adv 7:9347–935610.1039/C6RA28345D ↗
54. Dubey N, Dhiman S, Koner AL (2023) Review of carbon dot-based drug conjugates for cancer therapy. ACS Appl Nano Mater 6:4078–409610.1021/acsanm.2c05407 ↗
55. Lin W, Zhang X, Qian L, Yao N, Pan Y, Zhang L (2017) Doxorubicin-loaded unimolecular micelle-stabilized gold nanoparticles as a theranostic nanoplatform for tumor-targeted chemotherapy and computed tomography imaging. Biomacromolecules 18:3869–388010.1021/acs.biomac.7b00810 ↗
56. Jeong Y-I, Jin S-G, Kim I-Y, Pei J, Wen M, Jung T-Y, Moon K-S, Jung S (2010) Doxorubicin-incorporated nanoparticles composed of poly (ethylene glycol)-grafted carboxymethyl chitosan and antitumor activity against glioma cells in vitro. Colloids Surf B Biointerfaces 79:149–15510.1016/j.colsurfb.2010.03.037 ↗
57. Sun T, Zheng M, Xie Z, Jing X (2017) Supramolecular hybrids of carbon dots with doxorubicin: synthesis, stability and cellular trafficking. Mater Chem Front 1:354–36010.1039/C6QM00042H ↗