Nano-magnetic sorted CD29 +/CD44 +/CD105 + Bone MSCs alleviate cyclosporine nephrotoxicity and renal fibrosis
Source abstract
Abstract
CD29/CD44/CD105-modified immunomagnetic liposomes (CD29/CD44/CD105-IMLs) were developed to isolate bone marrow mesenchymal stem cells (BMSCs) with distinct phenotypes. A key BMSC phenotype capable of alleviating chronic cyclosporine-induced nephropathy was identified through in vivo experiments in mice, demonstrating its potential as an effective adjunctive therapy for mitigating renal fibrosis-induced injury. Four weeks post-transplantation, mice receiving CD29 + , CD44 + , and CD105 + BMSC groups exhibited improved overall health compared to the control group. Western blot analysis of autophagy-related proteins LC3-II and P62 revealed significantly lower expression levels in the CD44 + BMSC group compared to the CD29 + and CD105 + BMSC groups. In vivo imaging further demonstrated enhanced chemotactic ability of CD44 + BMSCs in mice with chronic cyclosporine-induced nephropathy at various time points. These findings suggest that transplantation of CD29 + /CD44 + /CD105 + BMSCs can delay the progression of renal fibrosis in mice with cyclosporine-induced chronic kidney disease. Notably, CD44 + BMSCs exhibited superior efficacy in alleviating renal fibrosis compared to CD29 + and CD105 + BMSC groups.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: MicroRNA in disease regulation · Extracellular vesicles in disease · Mesenchymal stem cell research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (36)
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