Application of magnetic targeted fluorescence/magnetic resonance dual-modal imaging in cancer diagnosis
Source abstract
Abstract
We designed a new nanoprobe—NPAPF-Fe3O4 NPs (about 150 nm)—with magnetic targeting fluorescence/magnetic resonance dual-mode imaging by using the combination of an AIE dye NPAPF (bis(4-(N-(2-naphthyl)phenylamino) phenyl)-fumaronitrile) and Fe3O4 NPs. The size of the NPAPF-Fe3O4 NPs was about 150 nm. This design successfully overcame the fluorescence quenching of the organic fluorescent dyes in the presence of metallic materials, which could be used for imaging applications. Under the premise of ensuring fluorescence imaging, we introduced the magnetic resonance imaging contrast agent Fe3O4 NP with higher spatial resolution and high sensitivity, and also a magnetic field–assisted targeting effect. After the surface modification, the NPAPF-Fe3O4 NPs showed good dimensional stability, biocompatibility, and biosafety, and had a longer blood circulation time in vivo. The NPAPF-Fe3O4 NPs were used to study the in vivo and in vitro fluorescence imaging and in vitro magnetic resonance imaging. The results showed that the fluorescence intensity of NPAPF-Fe3O4 NPs was lower than that of NPAPF NPs at the same concentration in cell imaging experiments. However, due to the appropriate Fe3O4 NP doping ratio, better fluorescence imaging could be achieved by NPAPF-Fe3O4 NP both in vitro and in vivo. In addition, in vitro magnetic resonance imaging showed a linear relationship between the 1/T2 of NPAPF-Fe3O4 NPs and the concentration of Fe, which was a T2 contrast agent capable of magnetic resonance imaging. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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