Foam droplet separation for nanoparticle synthesis

A novel approach to nanoparticle synthesis was developed whereby foam bubble bursting produced aerosol droplets, an approach patterned after the marine foam aerosol cycle. The droplets were dried to remove solvent, leaving nanometer-sized particles composed of precursor material. Nanoparticles composed of sodium chloride (mean diameter, \(\bar{D}_{\rm p}\approx\) 100 nm), phosphotungstic acid (\(\bar{D}_{\rm p}\approx\) 55 nm), and bovine insulin (\({D}_{\rm p}\approx\) 5–30 nm) were synthesized. Foam droplet separation can be carried out at ambient temperature and pressure. The ‘soft’ nature of the process makes it compatible with a wide range of materials.