Fluorescent-magnetic nanocomposites grafted with mannose derivatives: preparation, characterization, and bioapplication
Source abstract
Abstract
In the experiments, multifunctional nanocomposites with fluorescence, superparamagnetism, and bioactivity were synthesized to isolate and detect bacteria. Fluorescent-magnetic nanocomposites (FMNPs) (Fe3O4@SiO2@FITC–SiO2, core/shell) were first synthesized. Then, FMNPs were conjugated with N-hydroxysuccinimide-activated 4-oxo-4-(prop-2-ynyloxy) butanoic acid (NHS-activated ester) by the linker of 3-aminopropyltriethoxysilane, and alkyne-functionalized fluorescent-magnetic nanocomposites (FMNPs-alkyne) were produced. After 3′-azidopropyl-O-α-d-manno-pyranoside was grafted on the surface of FMNPs-alkyne by click chemistry, the final product—mannose derivatives-grafted fluorescent-magnetic nanocomposites (FMNPs-mannose) were obtained. Common techniques (Nuclear magnetic resonance, ESI mass spectra, etc.) indicated the successful synthesis of the target products. The results of scanning electron microscopy, transmission electron microscopy, and dynamic light scattering showed that FMNPs with one or more magnetic cores have regular structure with a diameter around 100 nm. Fluorescence spectra and fluorescence microscopy indicated that those nanocomposites exhibited strong and stable fluorescence property. FMNPs-mannose have a saturation magnization of 6.88 emu/g at room temperature. FMNPs-mannose were applied to adhere to Escherichia coli ATCC25722 and Staphylococcus aureus ATCC6538. The results showed that FMNPs-mannose were able to specifically adhere to E. coli ATCC25722. However, it had no effect with S. aureus ATCC6538. The obtained FMNPs-mannose will find its application in bacteria detection and separation.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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