Design of Au/SPIO composite nanoparticle for facile and biocompatible surface functionalization via Au–S bond

Satoshi Seino; Yujin Shibata; Masayuki Yamanaka; Takashi Nakagawa; Yohei Mukai; Shinsaku Nakagawa; Takao A. Yamamoto

doi:10.1007/s11051-012-1305-7

journal article·2013-01

Design of Au/SPIO composite nanoparticle for facile and biocompatible surface functionalization via Au–S bond

Satoshi Seino, Yujin Shibata, Masayuki Yamanaka, Takashi Nakagawa, Yohei Mukai, Shinsaku Nakagawa, Takao A. Yamamoto

Journal of Nanoparticle Research· Volume 15· Issue 1

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Source abstract

Abstract

Immobilization of Au nanoparticles on super-paramagnetic iron-oxide (SPIO) enables facile and biocompatible surface functionalization via Au–S bond. Au/SPIO composite nanoparticle is easily modified by thiol-modified polyethylene glycol (PEG-SH), and they are successfully applied on MR tumor imaging. However, its large hydrodynamic size (~150 nm) still causes the accumulation to liver in vivo. In this study, we controlled the hydrodynamic size of Au/SPIO by testing different raw SPIOs and stabilizing polymers. As the best candidate, Au/Molday-ION which was synthesized from Molday-ION and polyvinyl alcohol comprised the hydrodynamic size of 56 nm. Moreover, PEGylated Au/Molday-ION showed excellent dispersibility in blood serum, with the hydrodynamic size of 65 nm. This surface functionalization strategy is effective for the constructions of magnetic nanocarriers for in vivo applications.

Source: openaire · Quality: candidate unverified · Source record ↗

Research context

Polymers Nanomaterials Biomaterials Composites

OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Micro and Nano Robotics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (15)

Show source-provided references

1. Allen TM, Cullis PR (2004) Science 303:1818–182210.1126/science.1095833 ↗

2. Balmayor ER, Azevedo HS, Reis RL (2011) Pharm Res 28:1241–125810.1007/s11095-011-0392-y ↗

3. Davis ME, Chen Z, Shin DM (2008) Nat Rev Drug Discov 7:771–78210.1038/nrd2614 ↗

4. Gupta AK, Gupta M (2005) Biomaterials 26:3995–402110.1016/j.biomaterials.2004.10.012 ↗

5. Kinoshita T, Seino S, Mizukoshi Y, Otome Y, Nakagawa T, Okitsu K, Yamamoto TA (2005) J Magn Magn Mater 293:106–11010.1016/j.jmmm.2005.01.050 ↗

6. Kinoshita T, Seino S, Mizukoshi Y, Nakagawa T, Yamamoto TA (2007) J Magn Magn Mater 311:255–25810.1016/j.jmmm.2006.10.1161 ↗

7. Kohler N, Fryxell GE, Zhang M (2004) J Am Chem Soc 126:7206–721110.1021/ja049195r ↗

8. Kojima H, Mukai Y, Yoshikawa M, Kamei K, Yoshikawa T, Morita M, Inubushi T, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S (2010) Bioconj Chem 21:1026–103110.1021/bc900487p ↗

9. Mitchell DG (1999) MRI principles. W.B. Saunders Company, Philadelphia

10. Mornet S, Vasseur S, Grasset F, Duguet E (2004) J Mater Chem 14:2161–217510.1039/b402025a ↗

11. Neuberger T, Schopf B, Hofmann H, Hofmann M, Rechenberg B (2005) J Magn Magn Mater 293:483–48610.1016/j.jmmm.2005.01.064 ↗

12. Seino S, Kinoshita T, Nakagawa T, Kojima T, Taniguchi R, Okuda S, Yamamoto TA (2008) J Nanopart Res 10:1071–107610.1007/s11051-007-9334-3 ↗

13. Seino S, Matsuoka Y, Kinoshita T, Nakagawa T, Yamamoto TA (2009) J Magn Magn Mater 321:1404–140710.1016/j.jmmm.2009.02.050 ↗

14. Wang M, Thanou M (2006) Pharmacol Res 62:90–9910.1016/j.phrs.2010.03.005 ↗

15. Weinstein JS, Varallyay CG, Dosa E, Gahramano S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA (2010) J Cereb Blood Flow Metab 30:15–3510.1038/jcbfm.2009.192 ↗