Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties
Source abstract
Abstract
Using sodium dodecyl sulphate micelles as template, hollow-cored calcium phosphate nanocapsules were produced. The surfaces of the nanocapsule were subsequently silanised by a polyethylene glycol (PEG)-based silane with an N-hydroxysuccinimide ester end groups which permits for further attachment with bisphosphonates (BP). Characterisations of these nanocapsules were investigated using Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy, Fourier Transform Infra-Red Spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Dynamic Light Scattering. To further validate the bone-targeting potential, dentine discs were incubated with these functionalised nanocapsules. FESEM analysis showed that these surface-modified nanocapsules would bind strongly to dentine surfaces compared to non-functionalised nanocapsules. We envisage that respective components would give this construct a bifunctional attribute, whereby (1) the shell of the calcium phosphate nanocapsule would serve as biocompatible coating aiding in gradual osteoconduction, while (2) surface BP moieties, acting as targeting ligands, would provide the bone-targeting potential of these calcium phosphate nanocapsules.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone health and treatments · Bone Tissue Engineering Materials · Bone health and osteoporosis research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (48)
Show source-provided references
1. Amaral IF, Granja PL, Barbosa MA (2005) Chemical modification of chitosan by phosphorylation: an XPS, FT-IR and SEM study. J Biomater Sci Polym Ed 16(12):1575–1593. doi: 10.1163/15685620577457673610.1163/156856205774576736 ↗
2. Barrère F, van der Valk CM, Meijer G, Dalmeijer RAJ, de Groot K, Layrolle P (2003) Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B Appl Biomater 67B(1):655–665. doi: 10.1002/jbm.b.1005710.1002/jbm.b.10057 ↗
3. Bodingbauer M, Wekerle T, Pakrah B, Silberhumer G, Roschger P, Peck-Radosavljevic M, Grampp S, Rockenschaub S, Steininger R, Berlakovich G, Oberbauer R, Klaushofer K, Muehlbacher F (2006) Prophylactic bisphosphonate treatment prevents bone fractures after liver transplantation. J Bone Miner Res 21:S71
4. Borum-Nicholas L, Wilson OC (2003) Surface modification of hydroxyapatite. Part I. Dodecyl alcohol. Biomaterials 24(21):3671–3679. doi: 10.1016/s0142-9612(03)00239-410.1016/S0142-9612(03)00239-4 ↗
5. Boutinguiza M, Pou J, Lusquinos F, Comesana R, Riveiro A (2011) Laser-assisted production of tricalcium phosphate nanoparticles from biological and synthetic hydroxyapatite in aqueous medium. Appl Surf Sci 257(12):5195–5199. doi: 10.1016/j.apsusc.2010.12.00410.1016/j.apsusc.2010.12.004 ↗
6. Bubbear JS, Gall A, Middleton FRI, Ferguson-Pell M, Swaminathan R, Keen RW (2011) Early treatment with zoledronic acid prevents bone loss at the hip following acute spinal cord injury. Osteoporos Int 22(1):271–279. doi: 10.1007/s00198-010-1221-610.1007/s00198-010-1221-6 ↗
7. Corrigan DO, Healy AM, Corrigan OI (2002) The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties. Int J Pharm 235(1–2):193–20510.1016/S0378-5173(01)00990-5 ↗
8. Cui FZ, Luo ZS (1999) Biomaterials modification by ion-beam processing. Surf Coat Technol 112(1–3):278–28510.1016/S0257-8972(98)00763-4 ↗
9. Dong JA, Uemura T, Shirasaki Y, Tateishi T (2002) Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells. Biomaterials 23(23):4493–450210.1016/S0142-9612(02)00193-X ↗
10. dos Santos MF, Furtado RNV, Konai MS, Castiglioni MLV, Marchetti RR, Silva CPG, Natour J (2011) Effectiveness of radiation synovectomy with Yttrium-90 and Samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled, randomized, double-blinded trial. Clin Rheumatol 30(1):77–85. doi: 10.1007/s10067-010-1626-910.1007/s10067-010-1626-9 ↗
11. Ducheyne P, Vanraemdonck W, Heughebaert JC, Heughebaert M (1986) Structural-analysis of hydroxyapatite coatings on titanium. Biomaterials 7(2):97–10310.1016/0142-9612(86)90063-3 ↗
12. Ebetino FH, Francis MD, Rogers MJ, Russell RGG (1998) Mechanisms of action of etidronate and other bisphosphonates. Rev Contemp Pharmacother 9(4):233–243
13. Ghosh SK, Nandi SK, Kundu B, Datta S, De DK, Roy SK, Basu D (2008) In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds. J Biomed Mater Res B Appl Biomater 86B(1):217–227. doi: 10.1002/jbm.b.3100910.1002/jbm.b.31009 ↗
14. Graf N, Gross T, Wirth T, Weigel W, Unger W (2009) Application of XPS and ToF-SIMS for surface chemical analysis of DNA microarrays and their substrates. Anal Bioanal Chem 393(8):1907–1912. doi: 10.1007/s00216-009-2599-x10.1007/s00216-009-2599-x ↗
15. Kang S-W, Yang HS, Seo S-W, Han DK, Kim B-S (2008) Apatite-coated poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for bone tissue engineering. J Biomed Mater Res A 85A(3):747–756. doi: 10.1002/jbm.a.3157210.1002/jbm.a.31572 ↗
16. Karabacak M, Coruh A, Kurt M (2008) FT-IR, FT-Raman, NMR spectra, and molecular structure investigation of 2,3-dibromo-N-methylmaleimide: a combined experimental and theoretical study. J Mol Struct 892(1–3):125–131. doi: 10.1016/j.molstruc.2008.05.01410.1016/j.molstruc.2008.05.014 ↗
17. Kim CW, Yun YP, Lee HJ, Hwang YS, Kwon IK, Lee SC (2010) In situ fabrication of alendronate-loaded calcium phosphate microspheres: controlled release for inhibition of osteoclastogenesis. J Controlled Release 147(1):45–53. doi: 10.1016/j.jconrel.2010.06.01610.1016/j.jconrel.2010.06.016 ↗
18. Kuriyama K, Hashimoto J, Murase T, Fujii M, Nampei A, Hirao M, Tsuboi H, Myoui A, Yoshikawa H (2009) Treatment of juxta-articular intraosseous cystic lesions in rheumatoid arthritis patients with interconnected porous calcium hydroxyapatite ceramic. Mod Rheumatol 19(2):180–186. doi: 10.1007/s10165-008-0147-810.1007/s10165-008-0147-8 ↗
19. Lange T, Schilling AF, Peters F, Haag F, Morlock MM, Rueger JM, Amling M (2009) Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro. Biomaterials 30(29):5312–5318. doi: 10.1016/j.biomaterials.2009.06.02310.1016/j.biomaterials.2009.06.023 ↗
20. Lee C-Y, Harbers GM, Grainger DW, Gamble LJ, Castner DG (2007) Fluorescence, XPS, and TOF-SIMS surface chemical state image analysis of DNA microarrays. J Am Chem Soc 129(30):9429–9438. doi: 10.1021/ja071879m10.1021/ja071879m ↗
21. Liao JG, Wang XJ, Zuo Y, Zhang L, Wen JQ, Li YB (2008) Surface modification of nano-hydroxyapatite with silane agent. J Inorg Mater 23(1):145–14910.3724/SP.J.1077.2008.00145 ↗
22. Liu Q, deWijn JR, Bakker D, vanBlitterswijk CA (1996) Surface modification of hydroxyapatite to introduce interfacial bonding with polyactive(TM) 70/30 in a biodegradable composite. J Mater Sci Mater Med 7(9):551–55710.1007/BF00122178 ↗
23. Liu Q, de Wijn JR, de Groot K, van Blitterswijk CA (1998) Surface modification of nano-apatite by grafting organic polymer. Biomaterials 19(11–12):1067–107210.1016/S0142-9612(98)00033-7 ↗
24. Liu Q, Ding J, Mante FK, Wunder SL, Baran GR (2002) The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer technique. Biomaterials 23(15):3103–311110.1016/S0142-9612(02)00050-9 ↗
25. Lu W, Zhang Y, Tan Y-Z, Hu K-L, Jiang X-G, Fu S-K (2005) Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery. J Controlled Release 107(3):428–44810.1016/j.jconrel.2005.03.027 ↗
26. Massiot P, Centeno MA, Carrizosa I, Odriozola JA (2001) Thermal evolution of sol-gel-obtained phosphosilicate solids (SiPO). J Non Cryst Solids 292(1–3):158–16610.1016/S0022-3093(01)00854-7 ↗
27. McLeod K, Kumar S, Smart RSC, Dutta N, Voelcker NH, Anderson GI, Sekel R (2006) XPS and bioactivity study of the bisphosphonate pamidronate adsorbed onto plasma sprayed hydroxyapatite coatings. Appl Surf Sci 253(5):2644–2651. doi: 10.1016/j.apsusc.2006.05.03110.1016/j.apsusc.2006.05.031 ↗
28. Mirji SA, Halligudi SB, Mathew N, Ravi V, Jacob NE, Patil KR (2006) Adsorption of methanol on Si(100)/SiO(2)and mesoporous SBA-15. Colloids Surf A 287(1–3):51–58. doi: 10.1016/j.colsurfa.2006.03.02110.1016/j.colsurfa.2006.03.021 ↗
29. Miyai T, Ito A, Tamazawa G, Matsuno T, Sogo Y, Nakamura C, Yamazaki A, Satoh T (2008) Antibiotic-loaded poly-epsilon-caprolactone and porous beta-tricalcium phosphate composite for treating osteomyelitis. Biomaterials 29(3):350–358. doi: 10.1016/j.biomaterials.2007.09.04010.1016/j.biomaterials.2007.09.040 ↗
30. Nandi SK, Kundu B, Ghosh SK, Mandal TK, Datta S, De DK, Basu D (2009) Cefuroxime-impregnated calcium phosphates as an implantable delivery system in experimental osteomyelitis. Ceram Int 35(4):1367–1376. doi: 10.1016/j.ceramint.2008.07.02210.1016/j.ceramint.2008.07.022 ↗
31. Ohura K, Bohner M, Hardouin P, Lemaitre J, Pasquier G, Flautre B (1996) Resorption of, and bone formation from, new beta-tricalcium phosphate-monocalcium phosphate cements: an in vivo study. J Biomed Mater Res 30(2):193–20010.1002/(SICI)1097-4636(199602)30:2<193::AID-JBM9>3.0.CO;2-M ↗
32. Okuda T, Ioku K, Yonezawa I, Minagi H, Kawachi G, Gonda Y, Murayama H, Shibata Y, Minami S, Kamihira S, Kurosawa H, Ikeda T (2007) The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials 28(16):2612–2621. doi: 10.1016/j.biomaterials.2007.01.04010.1016/j.biomaterials.2007.01.040 ↗
33. Olaru M, Simionescu BC, Cotofana C, Patras X (2008) Noncovalent immobilization of collagen on the surface of silanized hydroxyapatite. Optoelectron Adv Mater Rapid Commun 2(11):726–729
34. Ong HT, Loo JSC, Boey FYC, Russell SJ, Ma J, Peng KW (2008) Exploiting the high-affinity phosphonate-hydroxyapatite nanoparticle interaction for delivery of radiation and drugs. J Nanopart Res 10(1):141–150. doi: 10.1007/s11051-007-9239-110.1007/s11051-007-9239-1 ↗
35. Palazzo B, Iafisco M, Laforgia M, Margiotta N, Natile G, Bianchi CL, Walsh D, Mann S, Roveri N (2007) Biomimetic hydroxyapatite-drug nanocrystals as potential bone substitutes with antitumor drug delivery properties. Adv Funct Mater 17(13):2180–2188. doi: 10.1002/adfm.20060036110.1002/adfm.200600361 ↗
36. Puertolas JA, Vadillo JL, Sanchez-Salcedo S, Nieto A, Gomez-Barrena E, Vallet-Regi M (2011) Compression behaviour of biphasic calcium phosphate and biphasic calcium phosphate-agarose scaffolds for bone regeneration. Acta Biomater 7(2):841–847. doi: 10.1016/j.actbio.2010.07.03210.1016/j.actbio.2010.07.032 ↗
37. Russell RGG, Watts NB, Ebetino FH, Rogers MJ (2008) Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 19(6):733–759. doi: 10.1007/s00198-007-0540-810.1007/s00198-007-0540-8 ↗
38. Thian S, Huang J, Barber ZH, Best SM, Bonfield W (2011) Surface modification of magnetron-sputtered hydroxyapatite thin films via silicon substitution for orthopaedic and dental applications. Surf Coat Technol 205(11):3472–3477. doi: 10.1016/j.surfcoat.2010.12.01210.1016/j.surfcoat.2010.12.012 ↗
39. Tortora GJ, Derrickson B (2006) Principles of anatomy and physiology. Wiley, New York
40. van Beek ER, Lowik C, Ebetino FH, Papapoulos SE (1998) Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure–activity relationships. Bone 23(5):437–44210.1016/S8756-3282(98)00120-3 ↗
41. Vasiliev AN, Zlotnikov E, Khinast JG, Riman RE (2008) Chemisorption of silane compounds on hydroxyapatites of various morphologies. Scripta Mater 58(12):1039–1042. doi: 10.1016/j.scriptamat.2007.12.01410.1016/j.scriptamat.2007.12.014 ↗
42. Verron E, Gauthier O, Janvier P, Pilet P, Lesoeur J, Bujoli B, Guicheux J, Bouler JM (2010) In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite. Biomaterials 31(30):7776–7784. doi: 10.1016/j.biomaterials.2010.06.04710.1016/j.biomaterials.2010.06.047 ↗
43. Yang CL, Cheng K, Weng WJ, Yang CY (2009) OTS-modified HA and its toughening effect on PLLA/HA porous composite. J Mater Sci Mater Med 20(3):667–672. doi: 10.1007/s10856-008-3604-110.1007/s10856-008-3604-1 ↗
44. Yao J, Tjandra W, Chen YZ, Tam KC, Ma J, Soh B (2003) Hydroxyapatite nanostructure material derived using cationic surfactant as a template. J Mater Chem 13(12):3053–3057. doi: 10.1039/b308801d10.1039/b308801d ↗
45. Ye F, Lu XF, Lu B, Wang JJ, Shi YJ, Zhang L, Chen JQ, Li YP, Bu H (2007) A long-term evaluation of osteoinductive HA/beta-TCP ceramics in vivo: 4.5 years study in pigs. J Mater Sci Mater Med 18(11):2173–2178. doi: 10.1007/s10856-007-3215-210.1007/s10856-007-3215-2 ↗
46. Yu H, Ning C, Lin K, Chen L (2012) Preparation and characterization of PLLA/CaSiO3/apatite composite films. Int J Appl Ceram Technol 9(1):133–142. doi: 10.1111/j.1744-7402.2010.02606.x10.1111/j.1744-7402.2010.02606.x ↗
47. Yu-Song P (2011) Surface modification of nanocrystalline hydroxyapatite. Micro Nano Lett 6(3):129–132. doi: 10.1049/mnl.2010.018710.1049/mnl.2010.0187 ↗
48. Zobrist B, Weers U, Koop T (2003) Ice nucleation in aqueous solutions of poly ethylene glycol with different molar mass. J Chem Phys 118(22):10254–10261. doi: 10.1063/1.157181810.1063/1.1571818 ↗