Recent advances in nanomedicine for innovative oral cancer therapeutics—a review
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J Clinic 74(3):229–263. https://doi.org/10.3322/caac.2183410.3322/caac.21834 ↗
2. Gormley M, Creaney G, Schache A, Ingarfield K, Conway DI (2022) Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. Br Dent J 233(9):780–786. https://doi.org/10.1038/s41415-022-5166-x10.1038/s41415-022-5166-x ↗
3. Nakashima T, Tomita H, Hirata A, Ishida K, Hisamatsu K, Hatano Y … Hara A (2017) Promotion of cell proliferation by the proto‐oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization. Cancer Med 6(10): 2424–2439. https://doi.org/10.1002/cam4.115710.1002/cam4.1157 ↗
4. Montero PH, Patel SG (2015) Cancer of the oral cavity. Surg Oncol Clin N Am 24(3):491–508. https://doi.org/10.1016/j.soc.2015.03.00610.1016/j.soc.2015.03.006 ↗
5. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Abdollahi M (2017) Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer. Epidemiol Health 39:e2017009. https://doi.org/10.4178/epih.e201700910.4178/epih.e2017009 ↗
6. Borse V, Konwar AN, Buragohain P (2020) Oral cancer diagnosis and perspectives in India. Sensors Int 1:100046. https://doi.org/10.1016/j.sintl.2020.10004610.1016/j.sintl.2020.100046 ↗
7. Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M … Shakib P-A (2018) Oral cancer: a multicenter study. Med Oral, Patología Oral y Cirugía Bucal, 23(1), e23–e29. https://doi.org/10.4317/medoral.2199910.4317/medoral.21999 ↗
8. Dzebo S, Mahmutovic J, Erkocevic H (2017) Quality of life of patients with oral cavity cancer. Materia Socio-Medica 29(1):30–34. https://doi.org/10.5455/msm.2017.29.30-3410.5455/msm.2017.29.30-34 ↗
9. Huang SH, O´Sullivan, B. (2013) Oral cancer: current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal 18(2):e233–e240. https://doi.org/10.4317/medoral.1877210.4317/medoral.18772 ↗
10. Oun R, Moussa YE, Wheate NJ (2018) The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans 47(19):6645–6653. https://doi.org/10.1039/C8DT00838H10.1039/C8DT00838H ↗
11. van den Boogaard WMC, Komninos DSJ, Vermeij WP (2022) Chemotherapy side-effects: not all DNA damage is equal. Cancers 14(3):627. https://doi.org/10.3390/cancers1403062710.3390/cancers14030627 ↗
12. Saka-Herrán C, Jané-Salas E, Mari-Roig A, Estrugo-Devesa A, López-López J (2021) Time-to-treatment in oral cancer: causes and implications for survival. Cancers 13(6):1321. https://doi.org/10.3390/cancers1306132110.3390/cancers13061321 ↗
13. Marcazzan S, Varoni EM, Blanco E, Lodi G, Ferrari M (2018) Nanomedicine, an emerging therapeutic strategy for oral cancer therapy. Oral Oncol 76:1–7. https://doi.org/10.1016/j.oraloncology.2017.11.01410.1016/j.oraloncology.2017.11.014 ↗
14. Shi J, Kantoff PW, Wooster R, Farokhzad OC (2017) Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer 17(1):20–37. https://doi.org/10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗
15. de Lázaro I, Mooney DJ (2021) Obstacles and opportunities in a forward vision for cancer nanomedicine. Nat Mater 20(11):1469–1479. https://doi.org/10.1038/s41563-021-01047-710.1038/s41563-021-01047-7 ↗
16. Habban Akhter Md, Sateesh Madhav N, Ahmad J (2018) Epidermal growth factor receptor based active targeting: a paradigm shift towards advance tumor therapy. Art Cells Nanomed Biotechnol 46(sup2):1188–1198. https://doi.org/10.1080/21691401.2018.148186310.1080/21691401.2018.1481863 ↗
17. Akhter MdH, Rizwanullah Md, Ahmad J, Ahsan MJ, Mujtaba MdA, Amin S (2018) Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics. Art Cells Nanomed Biotechnol 46(5):873–884. https://doi.org/10.1080/21691401.2017.136633310.1080/21691401.2017.1366333 ↗
18. Ahmad J, Ahmad MZ, Akhter H (2020) Surface-engineered cancer nanomedicine: rational design and recent progress. Curr Pharmaceutical Design 26(11):1181–1190. https://doi.org/10.2174/138161282666620021411064510.2174/1381612826666200214110645 ↗
19. Chen J, Zhu Z, Pan Q, Bai Y, Yu M, Zhou Y (2023) Targeted therapy of oral squamous cell carcinoma with cancer cell membrane coated Co-Fc nanoparticles via autophagy inhibition. Adv Func Mater 33(24):2300235. https://doi.org/10.1002/adfm.20230023510.1002/adfm.202300235 ↗
20. Pradhan R, Chatterjee S, Hembram KC, Sethy C, Mandal M, Kundu CN (2021) Nano formulated resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages. J Nutr Biochem 92:108624. https://doi.org/10.1016/j.jnutbio.2021.10862410.1016/j.jnutbio.2021.108624 ↗
21. Kargozar S, Hoseini SJ, Milan PB, Hooshmand S, Kim H, Mozafari M (2020) Quantum dots: a review from concept to clinic. Biotechnol J 15(12):2000117. https://doi.org/10.1002/biot.20200011710.1002/biot.202000117 ↗
22. Li X, Lovell JF, Yoon J, Chen X (2020) Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol 17(11):657–674. https://doi.org/10.1038/s41571-020-0410-210.1038/s41571-020-0410-2 ↗
23. Mohammadinejad R, Moosavi MA, Tavakol S, Vardar DÖ, Hosseini A, Rahmati M … Klionsky DJ (2019) Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles. Autophagy 15(1): 4–33. https://doi.org/10.1080/15548627.2018.150917110.1080/15548627.2018.1509171 ↗
24. Hoffmann C, Calugaru V, Borcoman E, Moreno V, Calvo E, Liem X … Le Tourneau C (2021) Phase I dose-escalation study of NBTXR3 activated by intensity-modulated radiation therapy in elderly patients with locally advanced squamous cell carcinoma of the oral cavity or oropharynx. Eur J Cancer 146: 135–144. https://doi.org/10.1016/j.ejca.2021.01.00710.1016/j.ejca.2021.01.007 ↗
25. Freitas RA (2005) What is nanomedicine? Nanomed: Nanotechnol Biol Med 1(1):2–9. https://doi.org/10.1016/j.nano.2004.11.00310.1016/j.nano.2004.11.003 ↗
26. Miller CR, Bondurant B, McLean SD, McGovern KA, O’Brien DF (1998) Liposome−cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. Biochemistry 37(37):12875–12883. https://doi.org/10.1021/bi980096y10.1021/bi980096y ↗
27. Crommelin DJA, van Hoogevest P, Storm G (2020) The role of liposomes in clinical nanomedicine development. What now? Now what? J Control Release 318:256–263. https://doi.org/10.1016/j.jconrel.2019.12.02310.1016/j.jconrel.2019.12.023 ↗
28. Barenholz Y (2012) Doxil® — the first FDA-approved nano-drug: lessons learned. J Control Release 160(2):117–134. https://doi.org/10.1016/j.jconrel.2012.03.02010.1016/j.jconrel.2012.03.020 ↗
29. Gandek TB, van der Koog L, Nagelkerke A (2023) A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles. Adv Healthcare Mater 12(25):2300319. https://doi.org/10.1002/adhm.20230031910.1002/adhm.202300319 ↗
30. Singh A, Neupane YR, Shafi S, Mangla B, Kohli K (2020) PEGylated liposomes as an emerging therapeutic platform for oral nanomedicine in cancer therapy: in vitro and in vivo assessment. J Mol Liq 303:112649. https://doi.org/10.1016/j.molliq.2020.11264910.1016/j.molliq.2020.112649 ↗
31. Habib L, Alyan M, Ghantous Y, Shklover J, Shainsky J, Abu El-Naaj I … Schroeder A (2023) A mucoadhesive patch loaded with freeze-dried liposomes for the local treatment of oral tumors. Drug Del Transl Res 13(5): 1228–1245. https://doi.org/10.1007/s13346-022-01224-410.1007/s13346-022-01224-4 ↗
32. Li X, Zhao Z, Yang Y, Liu Z, Wang J, Xu Y, Zhang Y (2020) Novel β-1,3- d -glucan porous microcapsule enveloped folate-functionalized liposomes as a Trojan horse for facilitated oral tumor-targeted co-delivery of chemotherapeutic drugs and quantum dots. J Mater Chem B 8(11):2307–2320. https://doi.org/10.1039/C9TB02674F10.1039/C9TB02674F ↗
33. Lopes-Nunes J, Simões P, Moreira D, Leandro K, Nobre RJ, Pereira de Almeida L … Cruz C (2024) RNA-based liposomes for oral cancer: from biophysical characterization to biological evaluation. Int J Biol Macromol 259: 129157. https://doi.org/10.1016/j.ijbiomac.2023.12915710.1016/j.ijbiomac.2023.129157 ↗
34. Flores-Rojas GG, López-Saucedo F, Vera-Graziano R, Mendizabal E, Bucio E (2022) Magnetic nanoparticles for medical applications: updated review. Macromol 2(3):374–390. https://doi.org/10.3390/macromol203002410.3390/macromol2030024 ↗
35. Ferreira M, Sousa J, Pais A, Vitorino C (2020) The role of magnetic nanoparticles in cancer nanotheranostics. Materials 13(2):266. https://doi.org/10.3390/ma1302026610.3390/ma13020266 ↗
36. Pucci C, Degl’Innocenti A, Gümüş MB, Ciofani G (2022) Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era. Biomater Sci 10(9):2103–2121. https://doi.org/10.1039/D1BM01963E10.1039/D1BM01963E ↗
37. Nowak-Jary J, Machnicka B (2022) Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications. J Nanobiotechnol 20(1):305. https://doi.org/10.1186/s12951-022-01510-w10.1186/s12951-022-01510-w ↗
38. Liu JF, Jang B, Issadore D, Tsourkas A (2019) Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting. Wiley Interdisciplinary Rev Nanomed Nanobiotechnol 11(6):e1571. https://doi.org/10.1002/wnan.157110.1002/wnan.1571 ↗
39. Legge CJ, Colley HE, Lawson MA, Rawlings AE (2019) Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer. J Oral Pathol Med 48(9):803–809. https://doi.org/10.1111/jop.1292110.1111/jop.12921 ↗
40. Dhawan U, Tseng C-L, Wu P-H, Liao M-Y, Wang H-Y, Wu KC-W, Chung R-J (2023) Theranostic doxorubicin encapsulated FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and medical imaging in oral carcinoma. Nanomed: Nanotechnol Biol Med 48:102652. https://doi.org/10.1016/j.nano.2023.10265210.1016/j.nano.2023.102652 ↗
41. Su Z, Liu D, Chen L, Zhang J, Ru L, Chen Z … Wang X (2019) CD44-targeted magnetic nanoparticles kill head and neck squamous cell carcinoma stem cells in an alternating magnetic field. Int J Nanomed 14: 7549–7560. https://doi.org/10.2147/IJN.S21508710.2147/IJN.S215087 ↗
42. Bu L, Rao L, Yu G, Chen L, Deng W, Liu J … Sun Z (2019) Cancer stem cell‐platelet hybrid membrane‐coated magnetic nanoparticles for enhanced photothermal therapy of head and neck squamous cell carcinoma. Adv Funct Mater 29(10): 1807733. https://doi.org/10.1002/adfm.20180773310.1002/adfm.201807733 ↗
43. Ma N, Wu F-G, Zhang X, Jiang Y-W, Jia H-R, Wang H-Y … Chen Z (2017) Shape-dependent radiosensitization effect of gold nanostructures in cancer radiotherapy: comparison of gold nanoparticles, nanospikes, and nanorods. ACS Appl Mater Interfaces 9(15): 13037–13048. https://doi.org/10.1021/acsami.7b0111210.1021/acsami.7b01112 ↗
44. Zhuang Y, Liu L, Wu X, Tian Y, Zhou X, Xu S … Ma Y (2019) Size and shape effect of gold nanoparticles in “far-field” surface plasmon resonance. Particle Particle Syst Character 36(1): 1800077. https://doi.org/10.1002/ppsc.20180007710.1002/ppsc.201800077 ↗
45. Dong YC, Hajfathalian M, Maidment PSN, Hsu JC, Naha PC, Si-Mohamed S … Cormode DP (2019) Effect of gold nanoparticle size on their properties as contrast agents for computed tomography. Scientific Rep 9(1): 14912. https://doi.org/10.1038/s41598-019-50332-810.1038/s41598-019-50332-8 ↗
46. Foroozandeh P, Aziz AA (2018) Insight into cellular uptake and intracellular trafficking of nanoparticles. Nanoscale Res Lett 13(1):339. https://doi.org/10.1186/s11671-018-2728-610.1186/s11671-018-2728-6 ↗
47. Xie X, Liao J, Shao X, Li Q, Lin Y (2017) The effect of shape on cellular uptake of gold nanoparticles in the forms of stars, rods, and triangles. Sci Rep 7(1):3827. https://doi.org/10.1038/s41598-017-04229-z10.1038/s41598-017-04229-z ↗
48. Alamzadeh Z, Beik J, Mirrahimi M, Shakeri-Zadeh A, Ebrahimi F, Komeili A … Moustakis C (2020) Gold nanoparticles promote a multimodal synergistic cancer therapy strategy by co-delivery of thermo-chemo-radio therapy. Eur J Pharmaceutical Sci 145: 105235. https://doi.org/10.1016/j.ejps.2020.10523510.1016/j.ejps.2020.105235 ↗
49. The Nobel Prize in Chemistry 2023 (n.d.) NobelPrize.org. Retrieved December 1, 2023, from https://www.nobelprize.org/prizes/chemistry/2023/press-release/
50. Bera D, Qian L, Tseng T-K, Holloway PH (2010) Quantum dots and their multimodal applications: a review. Materials 3(4):2260–2345. https://doi.org/10.3390/ma304226010.3390/ma3042260 ↗
51. Rao L, Zhang Q, Sun B, Wen M, Zhang J, Zhong G … Niu X (2022) Multicolor luminescent carbon dots: tunable photoluminescence, excellent stability, and their application in light-emitting diodes. Nanomater (Basel, Switzerland) 12(18): 3132. https://doi.org/10.3390/nano1218313210.3390/nano12183132 ↗
52. Liang Z, Khawar MB, Liang J, Sun H (2021) Bio-conjugated quantum dots for cancer research: detection and imaging. Front Oncol 11. https://doi.org/10.3389/fonc.2021.74997010.3389/fonc.2021.749970 ↗
53. Schmidt R, Krasselt C, Göhler C, von Borczyskowski C (2014) The fluorescence intermittency for quantum dots is not power-law distributed: a luminescence intensity resolved approach. ACS Nano 8(4):3506–3521. https://doi.org/10.1021/nn406562a10.1021/nn406562a ↗
54. Kumar A, Kumar D, Saikia M, Subramania A (2023) A review on plant derived carbon quantum dots for bio-imaging. Mater Adv 4(18):3951–3966. https://doi.org/10.1039/D3MA00254C10.1039/D3MA00254C ↗
55. Barroso MM (2011) Quantum dots in cell biology. J Histochem Cytochem 59(3):237–251. https://doi.org/10.1369/002215541139848710.1369/0022155411398487 ↗
56. Ma Y, Liu Y, Wang Y, Guo Y, Li Y, Li R … Wang J (2022) The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma. Mater Design 220: 110838. https://doi.org/10.1016/j.matdes.2022.11083810.1016/j.matdes.2022.110838 ↗
57. Sri S, Kumar R, Panda AK, Solanki PR (2018) Highly biocompatible, fluorescence, and zwitterionic carbon dots as a novel approach for bioimaging applications in cancerous cells. ACS Appl Mater Interfaces 10(44):37835–37845. https://doi.org/10.1021/acsami.8b1321710.1021/acsami.8b13217 ↗
58. Das RK, Panda S, Bhol CS, Bhutia SK, Mohapatra S (2019) N-doped carbon quantum dot (NCQD)-deposited carbon capsules for synergistic fluorescence imaging and photothermal therapy of oral cancer. Langmuir 35(47):15320–15329. https://doi.org/10.1021/acs.langmuir.9b0300110.1021/acs.langmuir.9b03001 ↗
59. Begines B, Ortiz T, Pérez-Aranda M, Martínez G, Merinero M, Argüelles-Arias F, Alcudia A (2020) Polymeric nanoparticles for drug delivery: recent developments and future prospects. Nanomaterials 10(7):1403. https://doi.org/10.3390/nano1007140310.3390/nano10071403 ↗
60. Ahmad MZ, Rizwanullah Md, Ahmad J, Alasmary MY, Akhter MdH, Abdel-Wahab BA … Haque A (2022) Progress in nanomedicine-based drug delivery in designing of chitosan nanoparticles for cancer therapy. Int J Polymeric Mater Polymeric Biomater 71(8): 602–623. https://doi.org/10.1080/00914037.2020.186973710.1080/00914037.2020.1869737 ↗
61. Bhardwaj H, Jangde RK (2023) Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications. Next Nanotechnol 2:100013. https://doi.org/10.1016/j.nxnano.2023.10001310.1016/j.nxnano.2023.100013 ↗
62. Dols-Perez A, Fornaguera C, Feiner-Gracia N, Grijalvo S, Solans C, Gomila G (2023) Effect of surface functionalization and loading on the mechanical properties of soft polymeric nanoparticles prepared by nano-emulsion templating. Colloids Surfaces. B Biointerfaces 222:113019. https://doi.org/10.1016/j.colsurfb.2022.11301910.1016/j.colsurfb.2022.113019 ↗
63. Ribovski L, de Jong E, Mergel O, Zu G, Keskin D, van Rijn P, Zuhorn IS (2021) Low nanogel stiffness favors nanogel transcytosis across an in vitro blood-brain barrier. Nanomed: Nanotechnol Biol Med 34:102377. https://doi.org/10.1016/j.nano.2021.10237710.1016/j.nano.2021.102377 ↗
64. Messina PV, Miguel Besada-Porto J, Ruso JM (2014) Self-assembly drugs: from micelles to nanomedicine. Curr Topics Med Chem 14(5):555–57110.2174/1568026614666140121112118 ↗
65. Jin G-W, Rejinold NS, Choy J-H (2022) Multifunctional polymeric micelles for cancer therapy. Polymers 14(22):4839. https://doi.org/10.3390/polym1422483910.3390/polym14224839 ↗
66. Kumbham S, Paul M, Bhatt H, Ghosh B, Biswas S (2020) Oleanolic acid-conjugated poly (D, l-lactide)-based micelles for effective delivery of doxorubicin and combination chemotherapy in oral cancer. J Mol Liq 320:114389. https://doi.org/10.1016/j.molliq.2020.11438910.1016/j.molliq.2020.114389 ↗
67. Kumbham S, Paul M, Itoo A, Ghosh B, Biswas S (2022) Oleanolic acid-conjugated human serum albumin nanoparticles encapsulating doxorubicin as synergistic combination chemotherapy in oropharyngeal carcinoma and melanoma. Int J Pharm 614:121479. https://doi.org/10.1016/j.ijpharm.2022.12147910.1016/j.ijpharm.2022.121479 ↗
68. Zeng D, Ma Z, Zan X, Luo T, Wang X, Gao X, Fu X (2024) A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy. Chin Chem Lett 35(3):108433. https://doi.org/10.1016/j.cclet.2023.10843310.1016/j.cclet.2023.108433 ↗
69. Kumar K, Kumar Shyamlal BR, Verma R, Kondaiah P, Chaudhary S (2020) Reduction-triggered doxorubicin delivery by self-assembled nanospheres of lipoylated caffeine. ChemMedChem 15(9):733–737. https://doi.org/10.1002/cmdc.20200007010.1002/cmdc.202000070 ↗
70. Liang J, Yang B, Zhou X, Han Q, Zou J, Cheng L (2021) Stimuli-responsive drug delivery systems for head and neck cancer therapy. Drug Delivery 28(1):272–284. https://doi.org/10.1080/10717544.2021.187618210.1080/10717544.2021.1876182 ↗
71. Mignani S, Shi X, Guidolin K, Zheng G, Karpus A, Majoral J-P (2021) Clinical diagonal translation of nanoparticles: case studies in dendrimer nanomedicine. J Control Release 337:356–370. https://doi.org/10.1016/j.jconrel.2021.07.03610.1016/j.jconrel.2021.07.036 ↗
72. University of California, San Diego (2014) AP5346 for recurrent/unresectable squamous cell carcinoma of the head and neck: a pilot study with clinical and biological endpoints (clinical trial registration No. NCT00415298). clinicaltrials.gov. Retrieved from https://clinicaltrials.gov/study/NCT00415298. Accessed 8 Jan 2024
73. NanoCarrier Co., Ltd (2021) Phase IIa/IIb clinical trial of NC-6004 in combination with pembrolizumab in subjects with recurrent or metastatic squamous cell carcinoma of the head and neck who have failed platinum or a platinum-containing regimen (clinical trial registration No. NCT03771820). clinicaltrials.gov. Retrieved from https://clinicaltrials.gov/study/NCT03771820. Accessed 8 Jan 2024
74. Subbiah V, Grilley-Olson JE, Combest AJ, Sharma N, Tran RH, Bobe I … Bazhenova LA (2018) Phase Ib/II trial of NC-6004 (nanoparticle cisplatin) plus gemcitabine in patients with advanced solid tumors. Clinical Cancer Res 24(1): 43–51. https://doi.org/10.1158/1078-0432.CCR-17-111410.1158/1078-0432.CCR-17-1114 ↗
75. Wagner AM, Spencer DS, Peppas NA (2018) Advanced architectures in the design of responsive polymers for cancer nanomedicine. J Appl Polym Sci 135(24):46154. https://doi.org/10.1002/app.4615410.1002/app.46154 ↗
76. Yakavets I, Millard M, Zorin V, Lassalle H-P, Bezdetnaya L (2019) Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: advanced delivery strategies. J Controlled Release: Official J Controlled Release Soc 304:268–287. https://doi.org/10.1016/j.jconrel.2019.05.03510.1016/j.jconrel.2019.05.035 ↗
77. Bajpai S, Tiwary SK, Sonker M, Joshi A, Gupta V, Kumar Y … Biswas S (2021) Recent advances in nanoparticle-based cancer treatment: a review. ACS Appl Nano Mater. https://doi.org/10.1021/acsanm.1c0077910.1021/acsanm.1c00779 ↗
78. Allen C, Her S, Jaffray DA (2017) Radiotherapy for cancer: present and future. Adv Drug Deliv Rev 109:1–2. https://doi.org/10.1016/j.addr.2017.01.00410.1016/j.addr.2017.01.004 ↗
79. Ianovski I, Mlynarek AM, Black MJ, Bahoric B, Sultanem K, Hier MP (2020) The role of brachytherapy for margin control in oral tongue squamous cell carcinoma. J Otolaryngol Head Neck Surg 49(1):74. https://doi.org/10.1186/s40463-020-00467-w10.1186/s40463-020-00467-w ↗
80. Carneiro-Neto JN, Moura LB, de Andrade CR (2017) Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: systematic review and meta-analysis current. Med Oral Patol Oral Cir Bucal 22(1):e15–e23. https://doi.org/10.4317/medoral.2131410.4317/medoral.21314 ↗
81. Brook I (2020) Late side effects of radiation treatment for head and neck cancer. Radiat Oncol J 38(2):84–92. https://doi.org/10.3857/roj.2020.0021310.3857/roj.2020.00213 ↗
82. Lee SY, Jeong EK, Ju MK, Jeon HM, Kim MY, Kim CH … Kang HS (2017) Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol Cancer 16: 10. https://doi.org/10.1186/s12943-016-0577-410.1186/s12943-016-0577-4 ↗
83. Liu Y, Yang M, Luo J, Zhou H (2020) Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer. Int J Oral Sci 12(1):1–12. https://doi.org/10.1038/s41368-020-00087-010.1038/s41368-020-00087-0 ↗
84. Song G, Cheng L, Chao Y, Yang K, Liu Z (2017) Emerging nanotechnology and advanced materials for cancer radiation therapy. Adv Mater 29(32):1700996. https://doi.org/10.1002/adma.20170099610.1002/adma.201700996 ↗
85. Choi J, Kim G, Cho SB, Im H-J (2020) Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme. J Nanobiotechnol 18(1):122. https://doi.org/10.1186/s12951-020-00684-510.1186/s12951-020-00684-5 ↗
86. Teraoka S, Kakei Y, Akashi M, Iwata E, Hasegawa T, Miyawaki D … Komori T (2018) Gold nanoparticles enhance X‑ray irradiation‑induced apoptosis in head and neck squamous cell carcinoma in vitro. Biomed Rep. https://doi.org/10.3892/br.2018.114210.3892/br.2018.1142 ↗
87. Popovtzer A, Mizrachi A, Motiei M, Bragilovski D, Lubimov L, Levi M … Popovtzer R (2016) Actively targeted gold nanoparticles as novel radiosensitizer agents: an in vivo head and neck cancer model. Nanoscale, 8(5): 2678–2685. ter10.1039/C5NR07496G ↗
88. Ahmed BS, Baijal G, Somashekar R, Iyer S, Nayak V (2022) Comparative study of one pot synthesis of PEGylated gold and silver nanoparticles for imaging and radiosensitization of oral cancers. Radiat Phys Chem 194:109990. https://doi.org/10.1016/j.radphyschem.2022.10999010.1016/j.radphyschem.2022.109990 ↗
89. Chen M-H, Chen M-H, Li C-Y, Tung F-I, Chen S-Y, Liu T-Y (2021) Using gold-nanorod-filled mesoporous silica nanobeads for enhanced radiotherapy of oral squamous carcinoma. Nanomaterials 11(9):2235. https://doi.org/10.3390/nano1109223510.3390/nano11092235 ↗
90. Shakerian Ardakani T, Meidanchi A, Shokri A, Shakeri-Zadeh A (2020) Fe3O4@Au/reduced graphene oxide nanostructures: combinatorial effects of radiotherapy and photothermal therapy on oral squamous carcinoma KB cell line. Ceram Int 46(18):28676–28685. https://doi.org/10.1016/j.ceramint.2020.08.02710.1016/j.ceramint.2020.08.027 ↗
91. Hosseini V, Mirrahimi M, Shakeri-Zadeh A, Koosha F, Ghalandari B, Maleki S … Kamrava SK (2018) Multimodal cancer cell therapy using Au@Fe2O3 core–shell nanoparticles in combination with photo-thermo-radiotherapy. Photodiagnosis Photodyn Ther 24: 129–135. https://doi.org/10.1016/j.pdpdt.2018.08.00310.1016/j.pdpdt.2018.08.003 ↗
92. Ahmed BS, Baijal G, Somashekar R, Nongkhlaw R, Nirmal J, Nayak V (2024) Improving chemoradiotherapy strategy with PEGylated doxorubicin loaded gold nanoparticles against oral cancers. Radiat Phys Chem 223:111921. https://doi.org/10.1016/j.radphyschem.2024.11192110.1016/j.radphyschem.2024.111921 ↗
93. Zhao M, Ji C, Dai H, Wang C, Liu R, Xie J … Gu Z (2023) Mussel-inspired tantalum nanocomposite hydrogels for in situ oral cancer treatment. ACS Appl Mater Interfaces 15(4): 4984–4995. https://doi.org/10.1021/acsami.2c2046710.1021/acsami.2c20467 ↗
94. Hoxhaj G, Manning BD (2020) The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nat Rev Cancer 20(2):74–88. https://doi.org/10.1038/s41568-019-0216-710.1038/s41568-019-0216-7 ↗
95. Lang L, Lam T, Chen A, Jensen C, Duncan L, Kong F-C … Teng Y (2020) Circumventing AKT-associated radioresistance in oral cancer by novel nanoparticle-encapsulated capivasertib. Cells 9(3): 533. https://doi.org/10.3390/cells903053310.3390/cells9030533 ↗
96. Rocchi P, Brichart-Vernos D, Lux F, Morfin I, David L, Rodriguez-Lafrasse C, Tillement O (2022) A new generation of ultrasmall nanoparticles inducing sensitization to irradiation and copper depletion to overcome radioresistant and invasive cancers. Pharmaceutics 14(4):814. https://doi.org/10.3390/pharmaceutics1404081410.3390/pharmaceutics14040814 ↗
97. Hartner L (2018) Chemotherapy for oral cancer. Dent Clin North Am 62(1):87–97. https://doi.org/10.1016/j.cden.2017.08.00610.1016/j.cden.2017.08.006 ↗
98. Wang S, Konorev EA, Kotamraju S, Joseph J, Kalivendi S, Kalyanaraman B (2004) Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: intermediacy of H(2)O(2)- and p53-dependent pathways. J Biol Chem 279(24):25535–25543. https://doi.org/10.1074/jbc.M40094420010.1074/jbc.M400944200 ↗
99. El-Hamid ESA, Gamal-Eldeen AM, Sharaf Eldeen AM (2019) Liposome-coated nano doxorubicin induces apoptosis on oral squamous cell carcinoma CAL-27 cells. Arch Oral Biol 103:47–54. https://doi.org/10.1016/j.archoralbio.2019.05.01110.1016/j.archoralbio.2019.05.011 ↗
100. Wang Y, Wan G, Li Z, Shi S, Chen B, Li C … Wang Y (2017) PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma. Int J Pharm 525(1): 21–31. https://doi.org/10.1016/j.ijpharm.2017.04.02710.1016/j.ijpharm.2017.04.027 ↗