Comparative in vitro toxicity assessment of spiked anisotropic gold nanostructures
Source abstract
Abstract
Gold nanobipyramids and nanostars are the nanostructures with sharp protrusions which endow them with unique electromagnetic and photochemical properties making them useful in various imaging and photoablation therapy applications of different diseases especially cancer. For any in vivo applications, it is desirable to understand the comparative cytotoxic profile of these nanostructures. Studies comparing the cytotoxicity of differently spiked nanostructures with each other are relatively scarce. In this context, the current study focuses on the investigation of biocompatibility and cytotoxicity of nanobipyramids and nanostars on RBCs and PC3 prostate cancer cell line respectively. The synthesized nanostructures are thoroughly characterized using UV-Vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and inductively coupled plasma mass spectroscopy (ICP-MS) analysis. Cytotoxicity studies are accomplished using metabolic assays (MTT and neutral red assays) and analyzing the membrane integrity of treated cells using flow cytometry. The results show nanostars to be less cytotoxic and more biocompatible than nanobipyramids. This study holds high significance for using the spiked nanostructures in in vivo applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoparticles: synthesis and applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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