Induction of cell death by magnetic particles in response to a gradient magnetic field inside a uniform magnetic field
Source abstract
Abstract
A new instrument based on a magnetic force produced by an alternating magnetic field gradient, which is obtained through Maxwell coils, inside a constant field magnet has been designed and used to produce cell death. We have determined the interaction of microparticles and cells under different conditions such as incubation time with microparticles, particle size, magnetic field exposition time, and different current waveforms at different frequencies to produce a magnetic field gradient. We determined that the highest rate of cell death occurs at a frequency of 1 Hz with a square waveform and 1 h of irradiation. This method could be of great interest to remove cancer cells due mainly to the alterations in stiffness observed in the membranes of the tumor cells. Cancer cells can be eliminated in response to the forces caused by the movement of magnetic nanoparticles of the appropriate size under the application of a specific magnetic field.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Magnetic and Electromagnetic Effects · Microbial Inactivation Methods · Electromagnetic Fields and Biological Effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (41)
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