Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery
Source abstract
Abstract
Paclitaxel (Tax) is an anticancer drug with extremely low water solubility, and development of the formulation without organic solvents is highly desirable. Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can be used effectively in drug delivery systems, but poor dispersibility in water limits its application. In this study, HA-decorated poly(lactide-co-glycolide) (PLG) spheres with several micrometers were prepared and characterized. PLG microspheres adsorbed Tax, independent in the HA decorating, and their water dispersibility was retained after the HA decorating. Tax-loaded HA-decorated PLG microspheres (Tax/HA/PLG) could thus be highly dispersed in water, increasing their cellular uptake. Most Tax molecules were stably adsorbed to the HA and HA-decorated PLG (HA/PLG) particles. Although the cytotoxicity of Tax-loaded HA was much lower than that of free Tax, the drug activity of Tax/HA/PLG was markedly improved. Since the morphology of microtubules was changed after the Tax/HA/PLG treatment, the HA/PLG could work as a carrier for Tax.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Advanced Drug Delivery Systems · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (22)
Show source-provided references
1. Acharya S, Sahoo SK (2011) PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Adv Drug Deliv Rev 63:170–183. doi: 10.1016/j.addr.2010.10.00810.1016/j.addr.2010.10.008 ↗
2. Bose S, Tarafder S (2012) Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review. Acta Biomater 8:1401–1421. doi: 10.1016/j.actbio.2011.11.01710.1016/j.actbio.2011.11.017 ↗
3. Chlopek J, Morawska-Chochol A, Paluszkiewicz C, Jaworska J, Kasperczyk J, Dobrzynski P (2009) FTIR and NMR study of poly(lactide-co-glycolide) and hydroxyapatite implant degradation under in vivo conditions. Polym Degrad Stab 94:1479–1485. doi: 10.1016/j.polymdegradstab.2009.05.01010.1016/j.polymdegradstab.2009.05.010 ↗
4. Choi S, Murphy WL (2010) Sustained plasmid DNA release from dissolving mineral coatings. Acta Biomater 6:3426–3435. doi: 10.1016/j.actbio.2010.03.02010.1016/j.actbio.2010.03.020 ↗
5. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V (2012) PLGA-based nanoparticles: an overview of biomedical applications. J Controll Release 161:505–522. doi: 10.1016/j.jconrel.2012.01.04310.1016/j.jconrel.2012.01.043 ↗
6. Dosio F, Reddy LH, Ferrero A, Stella B, Cattel L, Couvreur P (2010) Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation. Bioconjugate Chem 21:1349–1361. doi: 10.1021/bc100154g10.1021/bc100154g ↗
7. Fonseca C, Simões S, Gaspar R (2002) Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J Controll Release 83:273–286. doi: 10.1016/S0168-3659(02)00212-210.1016/S0168-3659(02)00212-2 ↗
8. Fredenberg S, Wahlgren M, Reslow M, Axelsson A (2011) The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review. Int J Pharm 415:34–52. doi: 10.1016/j.ijpharm.2011.05.04910.1016/j.ijpharm.2011.05.049 ↗
9. Ginebra MP, Canal C, Espanol M, Pastorino D, Montufar EB (2012) Calcium phosphate cements as drug delivery materials. Adv Drug Deliv Rev 64:1090–1110. doi: 10.1016/j.addr.2012.01.00810.1016/j.addr.2012.01.008 ↗
10. Jongpaiboonkit L, Franklin-Ford T, Murphy WL (2009) Growth of hydroxyapatite coatings on biodegradable polymer microspheres. ACS Appl Mater Interfaces 1:1504–1511. doi: 10.1021/am900171610.1021/am9001716 ↗
11. Koudelka S, Turánek J (2012) Liposomal paclitaxel formulations. J Controll Release 163:322–334. doi: 10.1016/j.jconrel.2012.09.00610.1016/j.jconrel.2012.09.006 ↗
12. Lee D, Upadhye K, Kumta PN (2012) Nano-sized calcium phosphate (CaP) carriers for non-viral gene deilvery. Mater Sci Eng B 177:289–302. doi: 10.1016/j.mseb.2011.11.00110.1016/j.mseb.2011.11.001 ↗
13. Lin Y, Li Y, Ooi CP (2012) 5-Fluorouracil encapsulated HA/PLGA composite microspheres for cancer therapy. J Mater Sci Mater Med 23:2453–2460. doi: 10.1007/s10856-012-4723-210.1007/s10856-012-4723-2 ↗
14. Luo C, Wang Y, Chen Q, Han X, Liu X, Sun J, He Z (2012) Advances of paclitaxel formulations based on nanosystem delivery technology. Mini Rev Med Chem 12:434–444. doi: 10.2174/13895571280049392410.2174/138955712800493924 ↗
15. Lv PP, Ma YF, Yu R, Yue H, Ni DZ, Wei W, Ma GH (2012) Targeted delivery of insoluble cargo (paclitaxel) by PEGylated chitosan nanoparticles grafted with Arg-Gly-Asp (RGD). Mol Pharm 9:1736–1747. doi: 10.1021/mp300051h10.1021/mp300051h ↗
16. Nizamutdinova IT, Lee GW, Son KH, Jeon SJ, Kang SS, Kim YS, Lee JH, Seo HG, Chang KC, Kim HJ (2008) Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol 33:485–491. doi: 10.3892/ijo_00000031
17. Shi X, Wang Y, Ren L, Gong Y, Wang DA (2009) Enhancing alendronate release from a novel PLGA/hydroxyapatite microspheric system for bone repairing applications. Pharm Res 26:422–430. doi: 10.1007/s11095-008-9759-010.1007/s11095-008-9759-0 ↗
18. Singla AK, Garg A, Aggarwal D (2002) Paclitaxel and its formulations. Int J Pharm 235:179–192. doi: 10.1016/S0378-5173(01)00986-310.1016/S0378-5173(01)00986-3 ↗
19. Wang S, Wen S, Shen M, Guo R, Cao X, Wang J, Shi X (2011) Aminopropyltriethoxysilane-mediated surface functionalization of hydroxyapatite nanoparticles: synthesis, characterization, and in vitro toxicity assay. Int J Nanomedicine 6:3449–3459. doi: 10.2147/IJN.S27166
20. Watanabe K, Nishio Y, Makiura R, Nakahira A, Kojima C (2013) Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells. Int J Pharm 446:81–86. doi: 10.1016/j.ijpharm.2013.02.00210.1016/j.ijpharm.2013.02.002 ↗
21. Xu Q, Czernuszka JT (2008) Controlled release of amoxicillin from hydroxyapatite-coated poly (lactic-co-glycolic acid) microspheres. J Controll Release 127:146–153. doi: 10.1016/j.jconrel.2008.01.01710.1016/j.jconrel.2008.01.017 ↗
22. Zhang D, Tian A, Xue X, Wang M, Qiu B, Wu A (2012) The effect of temozolomide/poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite microspheres on glioma U87 cells behavior. Int J Mol Sci 13:1109–1125. doi: 10.3390/ijms1301110910.3390/ijms13011109 ↗