Effect of synthesis conditions on local atomic structure and properties of low-toxic maghemite nanoparticles for local magnetic hyperthermia in oncology
Source abstract
Abstract
Low-toxic colloidal superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications were obtained by microwave-assisted technique. Nanoparticles were synthesized by the hydrothermal method under different conditions. XANES, XRD, and XPS studies support the maghemite (γ-Fe2O3) atomic and electronic structure of the nanoparticles. XANES data analysis reveals that nanoparticles have the structure reminiscent of the macroscopic maghemite. Mossbauer spectroscopy supports the γ-Fe2O3 phase of the nanoparticles and vibration magnetometry study shows that the nanoparticles appear to be superparamagnetic. Nanoparticle shape and size were studied by TEM and DLS methods. It was shown that the nanoparticles do not exceed 20 nm. Also, the nanoparticles are found to be low-toxic and did not have significant effects on the viability of the HeLa cell culture. The obtained nanoparticles generated heat with the highest ILP value of 2.56 nHm2/kg and can be considered potential candidates as heat mediators for local magnetic hyperthermia in oncology. Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Ultrasound and Hyperthermia Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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