Unraveling the pulmonary drug delivery carriers in inhalable nanostructures
Source abstract
Abstract
Nano-systems (size range: 1 ~ 1000 nm) have been widely investigated as pulmonary drug delivery carriers, and the safety of inhaled nano-systems has aroused general interests. In this work, bibliometric analysis was performed to describe the current situation of related literature, figure out the revolutionary trends, and eventually forecast the possible future directions. The relevant articles and reviews from 2001 to 2020 were retrieved from the Web of Science Core Collection. The documents were processed by Clarivate Analytic associated with Web of Science database, Statistical Analysis Toolkit for Informetric, bibliometric online platform and VOSviewer, and the data were visualized. The bibliometric overview of the literature was described, citation analysis was performed, and research hotspots were showcased. The bibliometric analysis of 3362 documents of interest indicated that most of the relevant source titles were in the fields of toxicology, pharmacy, and materials science. The three research hotspots were the biological process of inhalable nano-systems in vivo, the manufacture of inhalable nano-systems, and the impact of nano-systems on human health in the environment. Toxicity and safety have always been the keywords. The USA was the major contributing country, and international collaboration and co-authorship were common phenomena. The general situation and development trend of literature of inhalable nano-systems were summarized. It was anticipated that bibliometrics analysis could provide new ideas for the future research of inhalable nano-systems.The online version contains supplementary material available at 10.1007/s11051-021-05384-1.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Inhalation and Respiratory Drug Delivery · Nanoparticles: synthesis and applications · Air Quality and Health Impacts
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (72)
Show source-provided references
1. Alavi M, Varma RS (2021) Phytosynthesis and modification of metal and metal oxide nanoparticles/nanocomposites for antibacterial and anticancer activities: Recent advances. Sustainable Chemistry Pharmacy 21:100412. https://doi.org/10.1016/j.scp.2021.10041210.1016/j.scp.2021.100412 ↗
2. Al-Qadi S, Grenha A, Carrion-Recio D, Seijo B, Remunan-Lopez C (2012) Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations. J Control Release 157:383–390. https://doi.org/10.1016/j.jconrel.2011.08.00810.1016/j.jconrel.2011.08.008 ↗
3. Bakand S, Hayes A (2016) Toxicological considerations, toxicity assessment, and risk management of inhaled nanoparticles. Int J Mol Sci 17(6):929. https://doi.org/10.3390/ijms1706092910.3390/ijms17060929 ↗
4. Bihari A, Tripathi S, Deepak A (2021) A review on h-index and its alternative indices. J INF SCI. https://doi.org/10.1177/0165551521101447810.1177/01655515211014478 ↗
5. Borm P, Klaessig FC, Landry TD, Moudgil B, Pauluhn J, Thomas K, Trottier R, Wood S (2006) Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles. Toxicol Sci 90:23–32. https://doi.org/10.1093/toxsci/kfj08410.1093/toxsci/kfj084 ↗
6. Boyack KW, Klavans R (2010) Co-citation analysis, bibliographic coupling, and direct citation: which citation approach represents the research front most accurately? J Am Soc Inform Sci Technol 61:2389–2404. https://doi.org/10.1002/asi.v61:1210.1002/asi.v61:12 ↗
7. Chen W, Geng Y, Zhong S, Zhuang M, Pan H (2020) A bibliometric analysis of ecosystem services evaluation from 1997 to 2016. Environ Sci Pollut Res Int 27(19):23503–23513. https://doi.org/10.1007/s11356-020-08760-x10.1007/s11356-020-08760-x ↗
8. Chen Y, Cheng L, Lian R, Song Z, Tian J (2021) COVID-19 vaccine research focusses on safety, efficacy, immunoinformatics, and vaccine production and delivery: a bibliometric analysis based on VOSviewer. Biosci Trends 15:64–73. https://doi.org/10.5582/bst.2021.0106110.5582/bst.2021.01061 ↗
9. Creutzenberg O, Bellmann B, Korolewitz R, Koch W, Mangelsdorf I, Tillmann T, Schaudien D (2012) Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats. Inhal Toxicol 24:821–830. https://doi.org/10.3109/08958378.2012.72109710.3109/08958378.2012.721097 ↗
10. Dai T, Deng Z, Fang X, Lu H, He Y, Chang J, Wang S, Zhu N, Li L, Meng G (2021) In situ assembly of ordered hierarchical CuO microhemisphere nanowire arrays for high-performance bifunctional sensing applications. Small Methods 5:2100202. https://doi.org/10.1002/smtd.20210020210.1002/smtd.202100202 ↗
11. De Jong WH, Borm PJ (2008) Drug delivery and nanoparticles:applications and hazards. Int J Nanomed 3:133–149. https://doi.org/10.2147/ijn.s59610.2147/ijn.s596 ↗
12. Delshadi R, Bahrami A, McClements DJ, Moore MD, Williams L (2021) Development of nanoparticle-delivery systems for antiviral agents: a review. J Control Release 331:30–44. https://doi.org/10.1016/j.jconrel.2021.01.01710.1016/j.jconrel.2021.01.017 ↗
13. Dolatabadi ENJ, Hamishehkar H, Valizadeh H (2015) Development of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles: solid-state characterization and aerosol dispersion performance. Drug Dev Ind Pharm 41:1431–1437. https://doi.org/10.3109/03639045.2014.95611110.3109/03639045.2014.956111 ↗
14. Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forrest G, Alexander A (2006) Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92:5–22. https://doi.org/10.1093/toxsci/kfj13010.1093/toxsci/kfj130 ↗
15. Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V (2005) Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10. https://doi.org/10.1186/1743-8977-2-1010.1186/1743-8977-2-10 ↗
16. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77(2):347–357. https://doi.org/10.1093/toxsci/kfh01910.1093/toxsci/kfh019 ↗
17. Fernández-Paz C, Fernández-Paz E, Salcedo-Abraira P, Rojas S, Barrios-Esteban S, Csaba N, Horcajada P, Remuñán-López C (2021) Microencapsulated isoniazid-loaded metal-organic frameworks for pulmonary administration of antituberculosis drugs. Molecules 26(21):6408. https://doi.org/10.3390/molecules2621640810.3390/molecules26216408 ↗
18. Ganganboina AB, Dega NK, Tran HL, Darmonto W, Doong RA (2021) Application of sulfur-doped graphene quantum dots@gold-carbon nanosphere for electrical pulse-induced impedimetric detection of glioma cells. Biosens Bioelectron 181:113151. https://doi.org/10.1016/j.bios.2021.11315110.1016/j.bios.2021.113151 ↗
19. Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555–1560. https://doi.org/10.1289/ehp.800610.1289/ehp.8006 ↗
20. Grassian VH, O’Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS (2007) Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115:397–402. https://doi.org/10.1289/ehp.946910.1289/ehp.9469 ↗
21. Gu M, Torres JL, Li Y, Van Ry A, Greenhouse J, Wallace S, Chiang CI, Pessaint L, Jackson AM, Porto M, Kar S, Li Y, Ward AB, Wang Y (2021) One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization. Emerg Microbes Infect 10(1):2016–2029. https://doi.org/10.1080/22221751.2021.199435410.1080/22221751.2021.1994354 ↗
22. Hasanovic A, Zehl M, Reznicek G, Valenta C (2010) Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability. J Pharm. 61:1609–1616. https://doi.org/10.1211/jpp.61.12.000410.1211/jpp.61.12.0004 ↗
23. He J, Gong C, Qin J, Li M, Huang S (2019) Cancer cell membrane decorated silica nanoparticle loaded with miR495 and doxorubicin to overcome drug resistance for effective lung cancer therapy. Nanoscale Res Lett 14(1):339. https://doi.org/10.1186/s11671-019-3143-310.1186/s11671-019-3143-3 ↗
24. Huang X, Liu X, Shang Y, Qiao F, Chen G (2020a) Current trends in research on bone regeneration: a bibliometric analysis. Biomed Res Int. https://doi.org/10.1155/2020/878739410.1155/2020/8787394 ↗
25. Huang Z, Huang Y, Wang W, Fu F, Wang W, Dang S, Li C, Ma C, Zhang X, Zhao Z, Pan X, Wu C (2020b) Relationship between particle size and lung retention time of intact solid lipid nanoparticle suspensions after pulmonary delivery. J Control Release 325:206–222. https://doi.org/10.1016/j.jconrel.2020.06.00410.1016/j.jconrel.2020.06.004 ↗
26. Jin Q, Zhu W, Zhu J, Zhu J, Shen J, Liu Z, Yang Y, Chen Q (2021) Nanoparticle-mediated delivery of inhaled immunotherapeutics for treating lung metastasis. Advanced materials (Deerfield Beach, Fla.) 33:e2007557. https://doi.org/10.1002/adma.20200755710.1002/adma.202007557 ↗
27. Kaur R, Dennison SR, Burrow AJ, Rudramurthy SM, SwamiR GV, Katare OP, Kaushik A, Singh B, Singh KK (2021) Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention. J Nanobiotechnology 19:19. https://doi.org/10.1186/s12951-020-00731-110.1186/s12951-020-00731-1 ↗
28. Kong Y, Sun H, Zhang S, Zhao B, Zhao Q, Zhang X, Li H (2021) Oxidation process of lead sulfide nanoparticle in the atmosphere or natural water and influence on toxicity toward Chlorella vulgaris. J Hazard Mater 417:126016. https://doi.org/10.1016/j.jhazmat.2021.12601610.1016/j.jhazmat.2021.126016 ↗
29. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdorster G, Ziesenis A (2002) Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health-Part a-Current Issues 65:1513–1530. https://doi.org/10.1080/0098410029007164910.1080/00984100290071649 ↗
30. Li MN, Porter AL, Wang ZL (2017) Evolutionary trend analysis of nanogenerator research based on a novel perspective of phased bibliographic coupling. Nano Energy 34:93–102. https://doi.org/10.1016/j.nanoen.2017.02.02010.1016/j.nanoen.2017.02.020 ↗
31. Lin GX, Kotheeranurak V, Mahatthanatrakul A, Ruetten S, Yeung A, Lee SH, Ahn Y, Kim HS, Hofstetter C, Lee JH, Choi KC, Lewandrowski KU, Kim JS (2020) Worldwide research productivity in the field of full-endoscopic spine surgery: a bibliometric study. Eur Spine J 29(1):153–160. https://doi.org/10.1007/s00586-019-06171-210.1007/s00586-019-06171-2 ↗
32. Liu Q, Guan J, Qin L, Zhang X, Mao S (2020) Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery. Drug Discov Today 25:150–159. https://doi.org/10.1016/j.drudis.2019.09.02310.1016/j.drudis.2019.09.023 ↗
33. Liu QY, Ye Y (2012) A study on mining bibliographic records by designed software SATI: case study on library and information science. Journal of Information Resources Management 2(01):50–58. https://doi.org/10.13365/j.jirm.2012.01.01210.13365/j.jirm.2012.01.012 ↗
34. Liu T, Li L, Fu C, Liu H, Chen D, Tang F (2012) Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles. Biomaterials 33:2399–2407. https://doi.org/10.1016/j.biomaterials.2011.12.00810.1016/j.biomaterials.2011.12.008 ↗
35. Luo JL, Han HY, Jia F, Dong H (2020) Agricultural Co-operatives in the western world: a bibliometric analysis. J Clean Prod. https://doi.org/10.1016/j.jclepro.2020.12294510.1016/j.jclepro.2020.122945 ↗
36. Vanaki M, S, Holmes D, Suara K, Jayathilake PG, Brown R, (2020) Transport and fate of inhaled particles after deposition onto the airway surface liquid: a 3D numerical study. Comput Biol Med 117:103595. https://doi.org/10.1016/j.compbiomed.2019.10359510.1016/j.compbiomed.2019.103595 ↗
37. Ma C, Wu M, Ye W, Huang Z, Ma X, Wang W, Wang W, Huang Y, Pan X, Wu C (2021) Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties. Drug Deliv Transl Res 11:1218–1235. https://doi.org/10.1007/s13346-020-00849-710.1007/s13346-020-00849-7 ↗
38. Meike V, Vandebriel RJ, Doren EV, KramerE RZH, Serrano-Rojero CS, Gremmer ER, Mast J, Peters R, Hollman P (2012) Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano 6:7427–7442. https://doi.org/10.1021/nn302649p10.1021/nn302649p ↗
39. Migliaccio CT, Hamilton RF, Jr Shaw PK, Rhoderick JF, Deb S, Bhargava R, Harkema JR, Holian, A (2021) Respiratory and systemic impacts following MWCNT inhalation in B6C3F1/N mice. Part Fibre Toxicol 18(1):16. https://doi.org/10.1186/s12989-021-00408-z10.1186/s12989-021-00408-z ↗
40. Miller MR, Raftis JB, Langrish JP, McLean SG, Samutrtai P, Connell SP, Wilson S, Vesey AT, Fokkens P, Boere A, Krystek P, Campbell CJ, Hadoke P, Donaldson K, Cassee FR, Newby DE, Duffin R, Mills NL (2017) Inhaled nanoparticles accumulate at sites of vascular disease. ACS Nano 11(5):4542–4552. https://doi.org/10.1021/acsnano.6b0855110.1021/acsnano.6b08551 ↗
41. Muraca F, Boselli L, Castagnola V, Dawson KA (2020) Ultrasmall gold nanoparticle cellular uptake: influence of transient bionano interactions. Acs Applied Bio Material 3:3800–3808. https://doi.org/10.1021/acsabm.0c0037910.1021/acsabm.0c00379 ↗
42. Muralidharan P, Malapit M, Mallory E, Hayes D Jr, Mansour HM (2015) Inhalable nanoparticulate powders for respiratory delivery. Nanomedicine 11(5):1189–1199. https://doi.org/10.1016/j.nano.2015.01.00710.1016/j.nano.2015.01.007 ↗
43. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627. https://doi.org/10.1126/science.111439710.1126/science.1114397 ↗
44. Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H (2012) Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 46:607–621. https://doi.org/10.1021/ar300022h10.1021/ar300022h ↗
45. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839. https://doi.org/10.1289/ehp.733910.1289/ehp.7339 ↗
46. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437–445. https://doi.org/10.1080/0895837049043959710.1080/08958370490439597 ↗
47. Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67–74. https://doi.org/10.1038/nrd215310.1038/nrd2153 ↗
48. Peng S, Wang J, Lu C, Xu Z, Chai JJ, Ke Q, Deng XZ (2021) Emodin enhances cisplatin sensitivity in non-small cell lung cancer through Pgp downregulation. Oncol Lett 21:230. https://doi.org/10.3892/ol.2021.1249110.3892/ol.2021.12491 ↗
49. Qiu J, Xu J, Xia Y (2021) Nanobottles for controlled release and drug delivery. Adv Healthcare Mater 10:e2000587. https://doi.org/10.1002/adhm.20200058710.1002/adhm.202000587 ↗
50. Reshma PL, Unnikrishnan BS, Preethi GU, Syama HP, Archana MG, Remya K, Shiji R, Sreekutty J, Sreelekha TT (2019) Overcoming drug-resistance in lung cancer cells by paclitaxel loaded galactoxyloglucan nanoparticles. Int J Biol Macromol 136:266–274. https://doi.org/10.1016/j.ijbiomac.2019.06.07510.1016/j.ijbiomac.2019.06.075 ↗
51. Rezaeisadat M, Bordbar AK, Omidyan R (2021) Molecular dynamics simulation study of curcumin interaction with nano-micelle of PNIPAAm-b-PEG co-polymer as a smart efficient drug delivery system. J Mol Liq 332:115862. https://doi.org/10.1016/j.molliq.2021.11586210.1016/j.molliq.2021.115862 ↗
52. Ruaro B, Salton F, Braga L, Wade B, Confalonieri P, Volpe MC, Baratella E, Maiocchi S, Confalonieri M (2021) The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci 22:1–16. https://doi.org/10.3390/ijms2205256610.3390/ijms22052566 ↗
53. Ruzycka-Ayoush M, Kowalik P, Kowalczyk A, Bujak P, Nowicka AM, Wojewodzka M, Kruszewski M, Grudzinski IP (2021) Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells. Cancer Nanotechnol. https://doi.org/10.1186/s12645-021-00080-010.1186/s12645-021-00080-0 ↗
54. Sanchez VC, Jachak A, Hurt RH, Kane AB (2012) Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol 25:15–34. https://doi.org/10.1021/tx200339h10.1021/tx200339h ↗
55. Sharifi S, Behzadi S, Laurent S, Forrest ML, Stroeve P, Mahmoudi M (2012) Toxicity of nanomaterials. Chem Soc Rev 41:2323–2343. https://doi.org/10.1039/c1cs15188f10.1039/c1cs15188f ↗
56. Shi H, Magaye R, Castranova V, Zhao J (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:15. https://doi.org/10.1186/1743-8977-10-1510.1186/1743-8977-10-15 ↗
57. Sun Q, Li J, Le T (2018) Zinc oxide nanoparticle as a novel class of antifungal agents: current advances and future perspectives. J Agric Food Chem 66:11209–11220. https://doi.org/10.1021/acs.jafc.8b0321010.1021/acs.jafc.8b03210 ↗
58. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.2166010.3322/caac.21660 ↗
59. Sweileh WM, Moh’d Mansour A, (2020) Bibliometric analysis of global research output on antimicrobial resistance in the environment (2000–2019). Glob Health Res Policy 5:37. https://doi.org/10.1186/s41256-020-00165-010.1186/s41256-020-00165-0 ↗
60. Tan HW, An J, Chua CK, Tran T (2019) Metallic nanoparticle inks for 3D printing of electronics. Adv Electron Mater. https://doi.org/10.1002/aelm.20180083110.1002/aelm.201800831 ↗
61. Telange DR, Sohail NK, Hemke AT, Kharkar PS, Pethe AM (2021) Phospholipid complex-loaded self-assembled phytosomal soft nanoparticles: evidence of enhanced solubility, dissolution rate, ex vivo permeability, oral bioavailability, and antioxidant potential of mangiferin. Drug Deliv Transl Res 11:1056–1083. https://doi.org/10.1007/s13346-020-00822-410.1007/s13346-020-00822-4 ↗
62. van Eck NJ, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84:523–538. https://doi.org/10.1007/s11192-009-0146-310.1007/s11192-009-0146-3 ↗
63. Viceconte G, Petrosillo N (2020) COVID-19 R0: magic number or conundrum? Infect Dis Rep 12:8516. https://doi.org/10.4081/idr.2020.851610.4081/idr.2020.8516 ↗
64. Wan F, Nylander T, Foged C, Yang M, Baldursdottir SG, Nielsen HM (2019) Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring. J Colloid Interface Sci 545:162–171. https://doi.org/10.1016/j.jcis.2019.02.08810.1016/j.jcis.2019.02.088 ↗
65. Wang WH, Yang BB, Huang ZW, Huang Y, Hu P, Pan X, Wu CB (2021) Investigating the effect of particle size on cellular uptake by aggregation-caused quenching probe–encapsulating solid lipid nanoparticles, inhaled. J Pharm Innov (prepublish), https://doi.org/10.1007/S12247-021-09576-Z10.1007/S12247-021-09576-Z ↗
66. Wang Z, Wang C, Liu S, He W, Wang L, Gan JJ, Huang Z, Wang Z, Wei H, Zhang J (2017) Specifically formed corona on silica nanoparticles enhances transforming growth factor β1 activity in triggering lung fibrosis. ACS Nano 11:1659–1672. https://doi.org/10.1021/acsnano.6b0746110.1021/acsnano.6b07461 ↗
67. Wen ZM, Jie J, Zhang Y, Liu H, Peng LP (2017) A self-assembled polyjuglanin nanoparticle loaded with doxorubicin and anti-Kras siRNA for attenuating multidrug resistance in human lung cancer. Biochem Biophys Res Commun 493(4):1430–1437. https://doi.org/10.1016/j.bbrc.2017.09.13210.1016/j.bbrc.2017.09.132 ↗
68. Wu Y, Zhao X, Shang Y, Chang S, Dai L, Cao A (2021) Application-driven carbon nanotube functional materials. ACS Nano 15:7946–7974. https://doi.org/10.1021/acsnano.0c1066210.1021/acsnano.0c10662 ↗
69. Yang H, Gu S, Li J, Jin L, Xie X, Luo L, Xiao J, Li J, Li C, Chen Y (2021) Synthesis of boron carbonitride nanosheets using for delivering paclitaxel and their antitumor activity. Colloids Surf B Biointerfaces 198:111479. https://doi.org/10.1016/j.colsurfb.2020.11147910.1016/j.colsurfb.2020.111479 ↗
70. Zhang YN, Paynter J, Sou C, Fourfouris T, Wang Y, Abraham C, Ngo T, Zhang Y, He L, Zhu J (2021) Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants. bioRxiv. https://doi.org/10.1101/2021.03.26.43727410.1101/2021.03.26.437274 ↗
71. Zhao M, Liu M (2018) New avenues for nanoparticle-related therapies. Nanoscale Res Lett 13:136. https://doi.org/10.1186/s11671-018-2548-810.1186/s11671-018-2548-8 ↗
72. Zhu XL, Zhang Q, Wang Y, Wei F (2016) Review on the nanoparticle fluidization science and technology. Chin J Chem Eng 24:9–22. https://doi.org/10.1016/j.cjche.2015.06.00510.1016/j.cjche.2015.06.005 ↗