Small antimicrobial agents encapsulated in poly(epsilon-caprolactone)-poly(ethylene glycol) nanoparticles for treatment of S. aureus-infected wounds
Source abstract
Abstract
The bacterial infections, especially wound infection, have become a growing problem threatening the human health. Small molecular antimicrobial agents were synthesized to fight against the bacteria but the clinical application in wound inflection treatment was restricted because of their hydrophobicity and poor skin permeation. Here, we synthesized a novel quinoline compound to be used as an antimicrobial agent. Due to its hydrophobic property, this quinoline compound could be successfully encapsulated into poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) nanoparticles (NPs) with a mean size of about 100 nm and showed a sustained drug release manner in vitro. Compared to the free drug of this quinoline compound, these drug-loaded PCL-PEG NPs had better water solubility and lower cytotoxicity in vitro. Results of in vivo wound healing experiments demonstrated that these drug-loaded NPs could not only greatly suppress the bacterial infection around the wound, but also significantly accelerate the curing rate of wound. Thus, these quinoline compound-loaded PCL-PEG NPs could act as a promising drug delivery system for wound healing applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Wound Healing and Treatments · Antimicrobial agents and applications · Antimicrobial Peptides and Activities
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (23)
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