The effect of core and lanthanide ion dopants in sodium fluoride-based nanocrystals on phagocytic activity of human blood leukocytes
Source abstract
Abstract
Sodium fluoride-based β-NaLnF4 nanoparticles (NPs) doped with lanthanide ions are promising materials for application as luminescent markers in bio-imaging. In this work, the effect of NPs doped with yttrium (Y), gadolinium (Gd), europium (Eu), thulium (Tm), ytterbium (Yb) and terbium (Tb) ions on phagocytic activity of monocytes and granulocytes and the respiratory burst was examined. The surface functionalization of <10-nm NPs was performed according to our variation of patent pending ligand exchange method that resulted in meso-2,3-dimercaptosuccinic acid (DMSA) molecules on their surface. Y-core-based NCs were doped with Eu ions, which enabled them to be excited with UV light wavelengths. Cultures of human peripheral blood ( n = 8) were in vitro treated with five different concentrations of eight NPs for 24 h. In summary, neither type of nanoparticles is found toxic with respect to conducted test; however, some cause toxic effects (they have statistically significant deviations compared to reference) in some selected doses tested. Both core types of NPs (Y-core and Gd-core) impaired the phagocytic activity of monocytes the strongest, having minimal or none whatsoever influence on granulocytes and respiratory burst of phagocytic cells. The lowest toxicity was observed in Gd-core, Yb, Tm dopants and near-infrared nanoparticles. Clear dose-dependent effect of NPs on phagocytic activity of leukocytes and respiratory burst of cells was observed for limited number of samples.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Luminescence Properties of Advanced Materials · Inorganic Fluorides and Related Compounds · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Aude-Garcia C, Dalzon B, Ravanat J-L et al (2016) A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages. J Proteome 134:174–185. doi: 10.1016/j.jprot.2015.12.01310.1016/j.jprot.2015.12.013 ↗
2. Banski M, Podhorodecki A, Misiewicz J (2013) NaYF4 nanocrystals with TOPO ligands: synthesis-dependent structural and luminescent properties. Phys Chem Chem Phys PCCP 15:19232–19241. doi: 10.1039/c3cp52865k10.1039/c3cp52865k ↗
3. Brown DM, Johnston H, Gubbins E, Stone V (2014) Cytotoxicity and cytokine release in rat hepatocytes, C3A cells and macrophages exposed to gold nanoparticles—effect of biological dispersion media or corona. J Biomed Nanotechnol 10:3416–3429. doi: 10.1166/jbn.2014.187110.1166/jbn.2014.1871 ↗
4. Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess KL, Jones RL, Schlager JJ (2008) Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 43:13608–13619. doi: 10.1021/jp712087m10.1021/jp712087m ↗
5. Chen G, Ohulchanskyy TY, Liu S et al (2012) Core/Shell NaGdF4:Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications. ACS Nano 6:2969–2977. doi: 10.1021/nn204236210.1021/nn2042362 ↗
6. Chen S, Zhang C, Jia G et al (2014) Size-dependent cytotoxicity of europium doped NaYF4 nanoparticles in endothelial cells. Mater Sci Eng C 43:330–342. doi: 10.1016/j.msec.2014.07.02910.1016/j.msec.2014.07.029 ↗
7. Cui X, Mathe D, Kovács N et al (2015) Synthesis, characterization, and application of core–shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) nanoparticle as Trimodal (MRI, PET/SPECT, and optical) imaging agents. Bioconjug Chem. doi: 10.1021/acs.bioconjchem.5b0033810.1021/acs.bioconjchem.5b00338 ↗
8. Das GK, Stark DT, Kennedy IM (2014) Potential toxicity of up-converting nanoparticles encapsulated with a bilayer formed by ligand attraction. Langmuir ACS J Surf Colloids 30:8167–8176. doi: 10.1021/la501595f10.1021/la501595f ↗
9. Fröhlich E (2015) Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo. Int J Nanomedicine 10:3761-3778. doi: 10.2147/IJN.S8306810.2147/IJN.S83068 ↗
10. Haase H, Fahmi A, Mahltig B (2014) Impact of silver nanoparticles and silver ions on innate immune cells. J Biomed Nanotechnol 6:1146–1156. doi: 10.1166/jbn.2014.178410.1166/jbn.2014.1784 ↗
11. Herd HL, Bartlett KT, Gustafson JA et al (2015) Macrophage silica nanoparticle response is phenotypically dependent. Biomaterials 53:574–582. doi: 10.1016/j.biomaterials.2015.02.07010.1016/j.biomaterials.2015.02.070 ↗
12. Hou Y, Qiao R, Fang F et al (2013) NaGdF4 nanoparticle-based molecular probes for magnetic resonance imaging of intraperitoneal tumor xenografts in vivo. ACS Nano 7:330–338. doi: 10.1021/nn304837c10.1021/nn304837c ↗
13. Hu Y, Wu B, Jin Q et al (2016) Facile synthesis of 5 nm NaYF4:Yb/Er nanoparticles for targeted upconversion imaging of cancer cells. Talanta 152:504–512. doi: 10.1016/j.talanta.2016.02.03910.1016/j.talanta.2016.02.039 ↗
14. Jacques SL (2013) Optical properties of biological tissues: a review. Phys Med Biol 58:R37–R61. doi: 10.1088/0031-9155/58/11/R3710.1088/0031-9155/58/11/R37 ↗
15. Jung HJ, Pak PJ, Park SH et al (2014) Silver wire amplifies the signaling mechanism for IL-1beta production more than silver submicroparticles in human monocytic THP-1 cells. PLoS One 9:e112256. doi: 10.1371/journal.pone.011225610.1371/journal.pone.0112256 ↗
16. Liu C, Gao Z, Zeng J et al (2013) Magnetic/upconversion fluorescent NaGdF4:Yb,Er nanoparticle-based dual-modal molecular probes for imaging tiny tumors in vivo. ACS Nano 7:7227–7240. doi: 10.1021/nn403089810.1021/nn4030898 ↗
17. Ma D, Meng L, Chen Y et al (2015) NaGdF4:Yb3+/Er3 + @NaGdF4:Nd3 + @sodium-gluconate: multifunctional and biocompatible ultrasmall core–shell nanohybrids for UCL/MR/CT multimodal imaging. ACS Appl Mater Interfaces 7:16257–16265. doi: 10.1021/acsami.5b0519410.1021/acsami.5b05194 ↗
18. Małaczewska J (2015) Effect of oral administration of commercial gold nanocolloid on peripheral blood leukocytes in mice. Pol J Vet Sci 18:273–282. doi: 10.1515/pjvs-2015-003610.1515/pjvs-2015-0036 ↗
19. Müller K, Skepper JN, Posfai M et al (2007) Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro. Biomaterials 28:1629–1642. doi: 10.1016/j.biomaterials.2006.12.00310.1016/j.biomaterials.2006.12.003 ↗
20. Noculak A, Fhui YS, Banski M et al (2014) Yb3+ and Tm3+ concentration-dependent structural and optical properties of hexagonal NaGdF4 nanocrystals. J Nanopart Res. doi: 10.1007/s11051-014-2396-010.1007/s11051-014-2396-0 ↗
21. Prietl B, Meindl C, Roblegg E, Pieber TR, Lanzer G, Fröhlich E (2014) Nano-sized and micro-sized polystyrene particles affect phagocyte function. Cell Biol Toxicol 1:1–16. doi: 10.1007/s10565-013-9265-y10.1007/s10565-013-9265-y ↗
22. Shin SH, Ye MK, Kim HS, Kang HS (2007) The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int Immunopharmacol 13:1813–1818. doi: 10.1016/j.intimp.2007.08.02510.1016/j.intimp.2007.08.025 ↗
23. Sojka B, Kuricova M, Liskova A et al (2014) Hydrophobic sodium fluoride-based nanocrystals doped with lanthanide ions: assessment of in vitro toxicity to human blood lymphocytes and phagocytes. J Appl Toxicol JAT 34:1220–1225. doi: 10.1002/jat.305010.1002/jat.3050 ↗
24. Strehl C, Gaber T, Maurizi L et al (2015) Effects of PVA coated nanoparticles on human immune cells. Int J Nanomedicine 10:3429–3445. doi: 10.2147/IJN.S7593610.2147/IJN.S75936 ↗
25. Sudheendra L, Das GK, Li C et al (2014) NaGdF4:Eu3+ nanoparticles for enhanced X-ray excited optical imaging. Chem Mater 26:1881–1888. doi: 10.1021/cm404044n10.1021/cm404044n ↗
26. Tian J, Zeng X, Xie X et al (2015) Intracellular adenosine triphosphate deprivation through lanthanide-doped nanoparticles. J Am Chem Soc 137:6550–6558. doi: 10.1021/jacs.5b0098110.1021/jacs.5b00981 ↗
27. Wang B, Zhang Y, Mao Z et al (2014) Toxicity of ZnO nanoparticles to macrophages due to cell uptake and intracellular release of zinc ions. J Nanosci Nanotechnol 14:5688–5696. doi: 10.1166/jnn.2014.887610.1166/jnn.2014.8876 ↗
28. Wysokińska E, Cichos J, Zioło E et al (2016) Cytotoxic interactions of bare and coated NaGdF4:Yb(3+):Er(3+) nanoparticles with macrophage and fibroblast cells. Toxicol Vitro Int J Publ Assoc BIBRA 32:16–25. doi: 10.1016/j.tiv.2015.11.02110.1016/j.tiv.2015.11.021 ↗
29. Yang D, Kang X, Ma P’a et al (2013) Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery. Biomaterials 34:1601–1612. doi: 10.1016/j.biomaterials.2012.11.00410.1016/j.biomaterials.2012.11.004 ↗
30. Zeng L, Pan Y, Tian Y et al (2015) Doxorubicin-loaded NaYF4:Yb/Tm–TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers. Biomaterials 57:93–106. doi: 10.1016/j.biomaterials.2015.04.00610.1016/j.biomaterials.2015.04.006 ↗
31. Zhou J-C, Yang Z-L, Dong W et al (2011) Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals. Biomaterials 32:9059–9067. doi: 10.1016/j.biomaterials.2011.08.03810.1016/j.biomaterials.2011.08.038 ↗