Studying the loading effect of acidic type antioxidant on amorphous silica nanoparticle carriers
Source abstract
Abstract
The study investigates the suitable nanosilica carriers to transport acidic type cargo molecules for potential targeted drug delivery application. Using phenolic acidic type antioxidant gallic acid (GA) as model compound, the present study investigates the loading effect of GA (0.3–15.9 mmol GA g−1 support) on textural characteristics of amorphous silica nanoparticles such as Q10 silica (1D), structured two-dimensional Si-MCM-41 (2D), and three-dimensional Si-SBA-16 (3D). The variation in the nature of textures after GA loading was analyzed using X-ray diffraction, N2 adsorption, FT-IR, scanning electron microscopy with energy dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy. Among the nanocarriers, high adsorption of GA was found in the following order: Si-SBA-16 (3D)∼Si-KIT-6 (3D) > Si-MCM-41 (2D) > ultralarge pore FDU-12 (ULPFDU-12; 3D) > Q10 (1D)∼mesostructured cellular silica foam (MSU-F). 3D-type silicas Si-SBA-16 and KIT-6 were shown to maintain structural integrity at acidic condition (pH ∼3) and accommodate GA in non-crystalline form. In the case of ULPFDU-12 and MSU-F cellular foam, only crystalline deposition of GA occurs with a significant variation in the surface area and pore volume.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Free Radicals and Antioxidants · Pigment Synthesis and Properties · Adsorption, diffusion, and thermodynamic properties of materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Andrade GF, Soares DCF, Almeida RK, Sousa EMB (2012) Mesoporous silica SBA-16 functionalized with alkoxysilane groups: preparation, characterization, and release profile study. J Nanomater 2012:816496. doi: 10.1155/2012/81649610.1155/2012/816496 ↗
2. Bruix J, Llovet JM (2002) Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35(3):519–524. doi: 10.1053/jhep.2002.3208910.1053/jhep.2002.32089 ↗
3. Halliwell B (1996) Antioxidants in human health and disease. Annu Rev Nutr 16:33–50. doi: 10.1146/annurev.nu.16.070196.00034110.1146/annurev.nu.16.070196.000341 ↗
4. Hu Y, Wang J, Zhi Z, Jiang T, Wang S (2011) Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug. J Colloid Interface Sci 363:410–417. doi: 10.1016/j.jcis.2011.07.02210.1016/j.jcis.2011.07.022 ↗
5. Hu H, Nie L, Feng S, Suo J (2013) Preparation, characterization and in vitro release study of gallic acid loaded silica nanoparticles for controlled release. Pharmazie 68:401–405. doi: 10.1691/ph.2013.220510.1691/ph.2013.2205 ↗
6. Kleitz F, Kim TW, Ryoo R (2006) Phase domain of the cubic Im3m mesoporous silica in the EO106PO70EO106−butanol−H2O system. Langmuir 22:440–445. doi: 10.1021/la052047+10.1021/la052047+ ↗
7. Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS (1992) Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature 359:710–712. doi: 10.1038/359710a010.1038/359710a0 ↗
8. Kruk M, Hui CM (2008) Synthesis and characterization of large-pore FDU-12 silica. Microporous Mesoporous Mater 114:64–73. doi: 10.1016/j.micromeso.2007.12.01510.1016/j.micromeso.2007.12.015 ↗
9. Manzano M, Aina V, Arean CO, Balas F, Cauda V, Collila M, Delgado MR, Regi MV (2008) Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chem Eng J 137:30–37. doi: 10.1016/j.cej.2007.07.07810.1016/j.cej.2007.07.078 ↗
10. Moller K, Bein T (2013) Mesoporosity—a new dimension for zeolites. Chem Soc Rev 42:3689–3707. doi: 10.1039/C3CS35488A10.1039/C3CS35488A ↗
11. Mustafa FM, Hodali HA (2015) Use of mesoporous silicate nanoparticles as drug carrier for mefenamic acid. Mater Sci Eng 92:012018. doi: 10.1088/1757-899X/92/1/01201810.1088/1757-899X/92/1/012018 ↗
12. Naghiloo M, Yousef M, Nourbakhsh MS, Taherian Z (2015) Functionalization of SBA-16 silica particles for ibuprofen delivery. J Sol-Gel Sci Technol 74:537–543. doi: 10.1007/s10971-015-3631-610.1007/s10971-015-3631-6 ↗
13. Nimse SB, Pal D (2015) Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv 5:27986–28006. doi: 10.1039/C4RA13315C10.1039/C4RA13315C ↗
14. Park K (2013) Facing the truth about nanotechnology in drug delivery. ACS Nano 7:7442–7447. doi: 10.1021/nn404501g10.1021/nn404501g ↗
15. Rabindran Jermy B, Cho DR, Bineesh KV, Kim SY, Park DW (2008) Direct synthesis of vanadium incorporated three-dimensional KIT-6: a systematic study in the oxidation of cyclohexane. Microporous Mesoporous Mater 115:281–292. doi: 10.1016/j.micromeso.2008.01.04010.1016/j.micromeso.2008.01.040 ↗
16. Rabindran Jermy B, Kim SY, Bineesh KV, Selvaraj M, Park DW (2009a) Easy route for the synthesis of Fe-SBA-16 at weak acidity and its catalytic activity in the oxidation of cyclohexene. Microporous Mesoporous Mater 121:103–113. doi: 10.1016/j.micromeso.2009.01.01010.1016/j.micromeso.2009.01.010 ↗
17. Rabindran Jermy B, Kim SY, Bineesh KV, Park DW (2009b) Optimization, synthesis and characterization of vanadium-substituted thick-walled three-dimensional SBA-16. Microporous Mesoporous Mater 117:661–669. doi: 10.1016/j.micromeso.2008.08.00910.1016/j.micromeso.2008.08.009 ↗
18. Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014) Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int 2014:761264. doi: 10.1155/2014/76126410.1155/2014/761264 ↗
19. Rashidi L, Vasheghani-Farahani E, Soleimani M, Atashi A, Rostami K, Gangi F, Fallahpour M, Tahouri MT (2014) A cellular uptake and cytotoxicity properties study of gallic acid-loaded mesoporous silica nanoparticles on Caco-2 cells. J Nanopart Res 16:2285. doi: 10.1007/s11051-014-2285-610.1007/s11051-014-2285-6 ↗
20. Ravikovitch PI, Neimark AV (2002) Density functional theory of adsorption in spherical cavities and pore size characterization of templated nanoporous silicas with cubic and three-dimensional hexagonal structures. Langmuir 18:1550–1560. doi: 10.1021/la010759410.1021/la0107594 ↗
21. Sakamoto Y, Kneda M, Terasaki O, Zhao DY, Kim JM, Stucky GD, Shin HJ, Ryoo R (2000) Direct imaging of the pores and cages of three-dimensional mesoporous materials. Nature 408:449. doi: 10.1038/3504404010.1038/35044040 ↗
22. Sayari A (1996) Catalysis by crystalline mesoporous molecular sieves. Chem Mater 8:1840–1852. doi: 10.1021/cm950585+10.1021/cm950585+ ↗
23. Schmidt-Winkel P, Glinka CJ, Stucky GD (2000) Microemulsion templates for mesoporous silica. Langmuir 16:356–361. doi: 10.1021/la990677410.1021/la9906774 ↗
24. Sengottuvelan M, Deeptha K, Nalini N (2009) Resveratrol ameliorates DNA damage, prooxidant and antioxidant imbalance in 1,2-dimethylhydrazine induced rat colon carcinogenesis. Chem Biol Interact 181:193–201. doi: 10.1016/j.cbi.2009.06.00410.1016/j.cbi.2009.06.004 ↗
25. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer 2012 statistics. CA Cancer J Clin 65:87–108. doi: 10.3322/caac.2126210.3322/caac.21262 ↗
26. Trewyn BG, Slowing II, Giri S, Chen H-T, Lin V-Y (2007) Synthesis and functionalization of a mesoporous silica nanoparticle based on the sol-gel process and applications in controlled release. Acc Chem Res 40:846–853. doi: 10.1021/ar600032u10.1021/ar600032u ↗
27. Vallet-Regi M, Bala F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem Int Ed 46:7548–7558. doi: 10.1002/anie.20060448810.1002/anie.200604488 ↗
28. Vijaya R, Jaganathan R, Panchanadham S, Palanivelu S (2012) Potential antioxidant role of Tridham in managing oxidative stress against aflatoxin-B1-induced experimental hepatocellular carcinoma. Int J Hepatol 2012:428373. doi: 10.1155/2012/42837310.1155/2012/428373 ↗
29. Wan MM, Sun XD, Liu S, Ma J, Zhu JH (2014) Versatile drug releaser derived from the Ti-substituted mesoporous silica SBA-15. Microporous Mesoporous Mater 199:40–49. doi: 10.1016/j.micromeso.2014.08.00510.1016/j.micromeso.2014.08.005 ↗
30. Yang X, Tang H, Cao K, Song H, Sheng W, Wu Q (2011) Templated-assisted one-dimensional silica nanotubes: synthesis and applications. J Mater Chem 21:6122–6135. doi: 10.1039/C0JM04516K10.1039/C0JM04516K ↗