Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats
Source abstract
Abstract
The aim of this study was to investigate the protective role of quercetin and/or l-arginine against the cardiotoxic potency of zinc oxide nanoparticle (ZnO-NP)-induced cardiac infarction. ZnO-NPs (50 nm) were administered orally at either 600 mg or 1 g/kg body weight for 5 consecutive days. The results revealed that co-administration of quercetin and/or l-arginine (each 200 mg/kg body weight) daily for 3 weeks to rats intoxicated by either of the two doses markedly ameliorated increases in serum markers of cardiac infarction, including troponin T, creatine kinase-MB, and myoglobin, as well as increases in proinflammatory biomarkers, including tumor necrosis factor-α, interleukin-6, and C-reactive protein, compared with intoxicated, untreated rats. Each agent alone or in combination also successfully modulated the alterations in serum vascular endothelial growth factor, cardiac calcium concentration, and oxidative DNA damage as well as the increase in the apoptosis marker caspase 3 of cardiac tissue in response to ZnO-NP toxicity. In conclusion, early treatment with quercetin and l-arginine may protect cardiac tissue from infarction induced by the toxic effects of ZnO-NPs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Trace Elements in Health · Cardiac Ischemia and Reperfusion
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (76)
Show source-provided references
1. Adamcova M, Kokstein Z, Vavrova J (1997) Clinical utility of cardiac troponin I and cardiac troponin T measurements. Acta Medica 40:83–87
2. Agarwal S, Tafel AA, Kanaar R (2006) DNA double-strand break repair and chromosome translocations. DNA Repair (Amst) 5:1075–108110.1016/j.dnarep.2006.05.029 ↗
3. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. J Am Coll Cardiol 36(3):959–96910.1016/S0735-1097(00)00804-4 ↗
4. Bischoff SC (2008) Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11:733–74010.1097/MCO.0b013e32831394b8 ↗
5. Chan ST, Chuang CH, Yeh CL, Liao JW, Liu KL, Tseng MJ, Yeh SL (2012) Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies. J Nutr Biochem 23:179–18510.1016/j.jnutbio.2010.11.014 ↗
6. Chen J, Kuhlencordt P, Urano F, Ichinose H, Astern J, Huang P (2003) Effects of chronic treatment with l-arginine on atherosclerosis in ApoE knockout and ApoE/Inducible NO synthase double-knockout mice. Arterioscler Thromb Vasc Biol 23:97–10310.1161/01.ATV.0000040223.74255.5A ↗
7. Chung DH, Evers BM, Townsend CM (1993) Role of polyamine biosynthesis during gut mucosal adaptation after burn injury. Am J Surg 165:144–14910.1016/S0002-9610(05)80418-0 ↗
8. Clauss M, Grell M, Fangmann C, Fiers W, Scheurich P, Risau W (1996) Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: functional analysis of the tumor necrosis factor receptors. FEBS Lett 390:334–33810.1016/0014-5793(96)00690-4 ↗
9. Collins AR, Dusinska M, Gedik CM, Stetina R (1996) Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect 104:465–46910.1289/ehp.96104s3465 ↗
10. Danenberg HD, Szalai AJ, Swaminathan RV et al (2003) Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation 108:512–51510.1161/01.CIR.0000085568.13915.1E ↗
11. De Ferranti SD, Rifai N (2007) C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovasc Pathol 16:14–2110.1016/j.carpath.2006.04.006 ↗
12. Dias AS, Porawski M, Alonso M, Marron N, Collado PS, Gallego JG (2005) Quercetin decreases oxidative stress, NF-κB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr 135:2299–230410.1093/jn/135.10.2299 ↗
13. Ding YH, Luan XD, Li J (2004) Exercise-induced overexpression of angiogenic factors and reduction of ischemia/reperfusion injury in stroke. Curr Neurovasc Res 1(5):411–42010.2174/1567202043361875 ↗
14. Duthie SL, Dobson VL (1999) Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. Eur J Nutr 38:28–3410.1007/s003940050043 ↗
15. Ekici OD, Isik N (2011) Investigation of the cardiotoxicity of imidocarb in lambs. Revue Med Vet 162:40–44
16. El-Missriy MA, Othman AI, Amer MA (2004) l-Arginine ameliorates oxidative stress in alloxan-induced experimental diabetes mellitus. J Appl Toxicol 24:93–9710.1002/jat.952 ↗
17. Fadda LM, Abdel Baky NA, Al-Rasheed NM, Al-rasheed NM, Fatani AJ, Atteya M (2012) Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC Complem Altern Med 12:6010.1186/1472-6882-12-60 ↗
18. Florio S, Ciarcia R, Crispino L, Pagnini U, Ruocco A, Kumar C, D’Andrilli G, Russo F (2003) Hydrocortisone has a protective effect on CyclosporinA-induced cardiotoxicity. J Cell Physiol 195(1):21–2610.1002/jcp.10216 ↗
19. Fromm RE (2007) Cardiac troponins in the intensive care unit: common causes of increased levels and interpretation. Crit Care Med 35:584–58810.1097/01.CCM.0000254349.10953.BE ↗
20. Ganguly PK, Pierce GN, Dhalla KS, Dhalla NS (1983) Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Physiol 244(6):E528–E535
21. Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI (2007) Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect 115(3):403–40910.1289/ehp.8497 ↗
22. Gurr JR, Wang AS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of phopactivation can induce oxidative DNA damage to human bronchial epithelial cells. Toxicol 15:66–7310.1016/j.tox.2005.05.007 ↗
23. Hamm CW, Ravkilde J, Gerhardt W, Jorgensen P, Peheim E, Ljungdahl L et al (1992) The prognostic value of serum troponin T in unstable angina. N Engl J Med 327(3):146–15010.1056/NEJM199207163270302 ↗
24. Hang L, Svanborg C, Andersson G (1994) Determination of interleukin 6 in human urine and epithelial cell supernatants. Int Arch Allergy Immunol 105:397–40310.1159/000236790 ↗
25. Hasenfuss G (1998) Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res 37:279–28910.1016/S0008-6363(97)00277-0 ↗
26. Heffernan D, Dudley B, McNeil PL, Howdieshell TR (2006) Local arginine supplementation results in sustained wound nitric oxide production and reductions in vascular endothelial growth factor expression and granulation tissue formation. J Surg Res 133:46–5410.1016/j.jss.2006.03.028 ↗
27. Heinlaan M, Ivask A, Blinova I, Dubourguier HC, Kahru A (2008) Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus. Chemosphere 71(7):1308–131610.1016/j.chemosphere.2007.11.047 ↗
28. Huang TH, Lee H, Kao CT (2001) Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay. J Endownllcs 27:744–748
29. Huang CC, Tsai SC, Lin WT (2008) Potential ergogenic effects of l-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Exp Gerontol 43:571–57710.1016/j.exger.2008.03.002 ↗
30. Irwin MW, Mak S, Mann DL, Qu R, Penninger JM, Yan A, Dawood F, Wen WH, Shou Z, Liu P (1999) Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. Circulation 99:1492–149810.1161/01.CIR.99.11.1492 ↗
31. Ivanov V, Cha J, Ivanova S, Kalinovsky T, Roomi MW, Rath M, Niedzwiecki A (2008) Essential nutrients suppress inflammation by modulating key inflammatory gene expression. Int J Mol Med 22:731–741
32. Kain V, Kumar S, Sitasawad S (2011) Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis. Cardiovasc Diabetol 10:97–13710.1186/1475-2840-10-97 ↗
33. Kambe D, Kotani M, Yoshimoto M, Kaku S, Chaki S, Honda K (2010) Effect of quercetin on the sleep-wake cycle in rats: involvement of gamma-aminobutyric acid receptors type A in regulation of rapid eye movement sleep. Brain Res 1330:83–8810.1016/j.brainres.2010.03.033 ↗
34. Kemp M, Donovan J, Higham H, Hooper J (2004) Biochemical markers of myocardial injury. Br J Anaesth 93(1):63–7310.1093/bja/aeh148 ↗
35. Kim JS, Yoon TJ, Yu KN, Kim BG, Park SJ, Kim HW, Lee KH, Park SB, Lee JK, Cho MH (2006) Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 89:338–34710.1093/toxsci/kfj027 ↗
36. Lin WS, Xu Y, Huang CC, Ma Y, Shannon KB, Chen DR, Huang YW (2009) Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 11:25–2910.1007/s11051-008-9419-7 ↗
37. Lingen MW (2001) Role of leukocytes and endothelial cells in the development of angiogenesis in inflammation and wound healing. Arch Pathol Lab Med 125:67–7110.5858/2001-125-0067-ROLAEC ↗
38. Liu J, Li X, Yue Y, Li J, He T, He Y (2005) The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Cell Mol Immunol 2:455–460
39. Lu S, Duffin R, Poland C, Daly P, Murphy F, Drost E (2009) Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environ Health Perspect 117:241–24710.1289/ehp.11811 ↗
40. Lucotti P, Monti L, Setola E, La Canna G, Castiglioni A, Rossodivita A, Pala MG, Formica F, Paolini G, Catapano AL, Bosi E, Alfieri O, Piatti P (2009) Oral l-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism Clin Exp 58:1270–127610.1016/j.metabol.2009.03.029 ↗
41. Marnett LJ (2002) Oxy radicals, lipid peroxidation and DNA damage. Toxicol 182:219–22210.1016/S0300-483X(02)00448-1 ↗
42. Martinez GR, Loureiro AP, Marques SA, Miyamoto S, Yamaguchi LF, Onuk J, Almeida EA, Garcia CC, Barbosa LF, Medeiros MH, Di Mascio P (2003) Oxidative and alkylating damage in DNA. Mutat Res 544:115–12710.1016/j.mrrev.2003.05.005 ↗
43. Mechtcheriakova D, Schabbauer G, Lucerna M, Clauss M, De Martin R, Binder BR, Hofer E (2001) Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. FASEB J 15:230–24210.1096/fj.00-0247com ↗
44. Moinard C, Cynober L, de Bandt JP (2005) Polyamines: metabolism and implications in human diseases. Clin Nutr 24:184–19710.1016/j.clnu.2004.11.001 ↗
45. Mroz RM, Schins RP, Li H, Jimenez LA, Drost EM, Holownia A, MacNee W, Donaldson K (2008) Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J 31(2):241–25110.1183/09031936.00006707 ↗
46. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–62710.1126/science.1114397 ↗
47. Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8(7):543–55710.1038/nmat2442 ↗
48. Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ (2003) Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem 278:31426–3143310.1074/jbc.M212549200 ↗
49. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nano-toxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–83910.1289/ehp.7339 ↗
50. Patel DN, King CA, Bailey SR (2007) Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. J Biol Chem 282:27229–2723810.1074/jbc.M703250200 ↗
51. Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L (2004) C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109:647–65510.1161/01.CIR.0000114526.50618.24 ↗
52. Pepys MB, Baltz ML (1983) Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol 34:141–21210.1016/S0065-2776(08)60379-X ↗
53. Piacenza L, Peluffo G, Radi R (2001) l-Arginine-dependent suppression of apoptosis in Trypanosoma cruzi: contribution of the nitric oxide and polyamine path ways. Proc Natl Acad Sci 98(13):7301–730610.1073/pnas.121520398 ↗
54. Piñeiro V, Moreno AO, Escobedo RM, Navarro MDH, Reyes GC, Cevallos GC (2010) Effect of l-arginine oral supplementation on response to myocardial infarction in hypercholesterolemic and hypertensive rats. Plant Foods Hum Nutr 65:31–3710.1007/s11130-009-0143-y ↗
55. Prior BM, Yang HT, Terjung RL (2004) What makes vessels grow with exercise training? J Appl Physiol 97(3):1119–112810.1152/japplphysiol.00035.2004 ↗
56. Punithavathi VR, Prince PSM (2010) Pretreatment with a combination of quercetin and α-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci 86:178–18410.1016/j.lfs.2009.11.021 ↗
57. Santos ES, Baltar VT, Pereira MP, Minuzzo L, Timerman A, Avezum A (2011) Comparison between cardiac troponin I and CK-MB mass in acute coronary syndrome without ST elevation. Arq Bras Cardiol 96(3):179–18710.1590/S0066-782X2011005000016 ↗
58. Service RF (2007) U.S. nanotechnology. Health and safety research slated for sizable gains. Science 315:92610.1126/science.315.5814.926a ↗
59. Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawan A (2009) DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 185:211–21810.1016/j.toxlet.2009.01.008 ↗
60. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–19110.1016/0014-4827(88)90265-0 ↗
61. Soukaloun D, Lee SJ, Chamberlain K, Taylor AM, Mayxay M, Sisouk K, Soumphonphakdy B, Latsavong K, Akkhavong K, Phommachanh D, Sengmeuang V, Luangxay K, McDonagh T, White NJ, Newton PN (2011) Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. PLoS Negl. Trop. Dis. 5:e971–e98110.1371/journal.pntd.0000971 ↗
62. Suematsu N, Tsutsui H, Wen JMD, Kang D, Ikeuchi M, Ide T, Hayashidani S, Shiomi T, Kubota T, Hamasaki N, Takeshita A (2003) Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 108:1418–142310.1161/01.CIR.0000055318.09997.1F ↗
63. Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, Szalai AJ, Ward ME, Verma S (2008) Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis 201(2):318–32510.1016/j.atherosclerosis.2008.02.034 ↗
64. Tice RR, Strauss GHS (1995) The single cell gel electrophoresis comet assay—a potential tool for detecting radiation-induced DNA damage in humans. Stem Cells 13(Suppl 1):207–214
65. Vaculova A, Zhivotovsky B (2008) Caspases: determination of their activities in apoptotic cells. Methods Enzymol 442:157–18110.1016/S0076-6879(08)01408-0 ↗
66. Venugopal SK, Devaraj S, Jialal I (2005) Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role. Curr Opin Nephrol Hypertens 14:33–3710.1097/00041552-200501000-00006 ↗
67. Verheul HM, Jorna AS, Hoekman K, Broxterman HJ, Gebbink MF, Pinedo HM (2000) Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood 96:4216–422110.1182/blood.V96.13.4216 ↗
68. Wang ZL (2004) Zinc oxide nanostructures: growth, properties and applications. J Phys: Condens Matter 16:829–85810.1088/0953-8984/16/25/R01 ↗
69. Wang B, Feng WY, Wang M, Wang TC, Gu YQ, Zhu MT, Ouyang H, Shi JW, Zhang F, Zhao YL, Chai ZF, Wang HF, Wang J (2008a) Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice. J Nanopart Res 10(2):263–27610.1007/s11051-007-9245-3 ↗
70. Wang Z, Zhou J, Fan J, Qiu SJ, Yu Y, Huang XW (2008b) Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma. Clin Cancer Res 14:5124–513010.1158/1078-0432.CCR-07-4774 ↗
71. Wilms LC, Hollman PC, Boots AW, Kleinjans JC (2005) Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 582:155–16210.1016/j.mrgentox.2005.01.006 ↗
72. Wu GH, Zhang YW, Wu ZH (2001) Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients. World J Gastroenterol 7:357–36210.3748/wjg.v7.i3.357 ↗
73. Xiong D, Fang T, Yu L, Sima X, Zhu W (2011) Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409:1444–145210.1016/j.scitotenv.2011.01.015 ↗
74. Yeha CL, Paib MH, Lic CC, Tsaia YL, Yehc SL (2010) Effect of arginine on angiogenesis induced by human colon cancer: in vitro and in vivo studies. J Nutr Biochem 21:538–54310.1016/j.jnutbio.2009.03.005 ↗
75. Yokoyama A, Sakakibara H, Crozier A, Kawai Y, Matsui A, Terao JK et al (2009) Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radic Res 43:913–92110.1080/10715760903137010 ↗
76. Zhang XJ, Chinkes DL, Wu Z, Herndon DN (2011) Enternal arginine supplementation stimulates DNA synthesis in skin donor. Wound Clin Nutr 30:391–39610.1016/j.clnu.2011.01.004 ↗