Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells
Source abstract
Abstract
For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe2O4 nanocrystals (PMNCs) and polycationics (poly-l-lysine, PLL) for efficient labeling of the h-MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG–dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (27)
Show source-provided references
1. Anderson SA, Glod J, Arbab AS, Noel M, Ashari P, Fine HA, Frank JA (2005) Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood 105:420–42510.1182/blood-2004-06-2222 ↗
2. Arbab AS, Bashaw LA, Miller BR, Jordan EK, Lewis BK, Kalish H, Frank JA (2003) Superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Radiology 229:838–84610.1148/radiol.2293021215 ↗
3. Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, Khakoo AY, Read EJ, Frank JA (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 15:1217–122310.1182/blood-2004-02-0655 ↗
4. Deans RJ, Moseley AB (2000) Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 28:875–88410.1016/S0301-472X(00)00482-3 ↗
5. Frank JA, Miller BR, Arbab AS et al (2003) Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 228:480–48710.1148/radiol.2281020638 ↗
6. Graham NB (1992) Poly(ethylene glycol) gels and drug delivery. In: Harris JM (ed) Poly(ethylene glycol) chemistry. Plenum Press, New York
7. Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26(18):3995–402110.1016/j.biomaterials.2004.10.012 ↗
8. He G, Zhang H, Wei H, Wang Y, Zhang X, Tang Y, Wei Y, Hu S (2007) In vivo imaging of bone marrow mesenchymal stem cells transplanted into myocardium using magnetic resonance imaging: a novel method to trace the transplanted cells. Int J Cardiol 114:4–1010.1016/j.ijcard.2005.11.112 ↗
9. Horak D, Babic M, Jendelova P, Herynek V, Trchova M, Pientka Z, Pollert E, Hajek M, Sykova E (2007) d-Mannose-modified iron oxide nanoparticles for stem cell labeling. Bioconj Chem 18:635–64410.1021/bc060186c ↗
10. Jun YW, Huh YM, Choi JS, Lee JH, Song HT, Kim S, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J (2005) Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc 127:5732–573310.1021/ja0422155 ↗
11. Kopen GC, Prockop DJ, Phinney DG (1999) Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96:10711–1071610.1073/pnas.96.19.10711 ↗
12. Lee JH, Huh YM, Jun YW, Seo JW, Jang JT, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13:95–9910.1038/nm1467 ↗
13. Li Z, Wei L, Gao M, Lei H (2005) One-pot reaction to synthesize biocompatible magnetite nanoparticles. Adv Mater 17:1001–100510.1002/adma.200401545 ↗
14. Lorenz MR, Holzapfel V, Musyanovych A, Nothelfer K, Walther P, Frank H, Landfester K, Schrezenmeier H, Mailänder V (2006) Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells. Biomaterials 27:2820–282810.1016/j.biomaterials.2005.12.022 ↗
15. Lu CW, Hung Y, Hsiao JK, Yao M, Chung TH, Lin YS, Wu SH, Hsu SC, Liu HM, Mou CY, Yang CS, Huang DM, Chen YC (2007) Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling. Nano Lett 7:149–15410.1021/nl0624263 ↗
16. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S (1999) Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697–70510.1172/JCI5298 ↗
17. McCurrie RA (1994) Ferrimagnetic materials, 1st edn, chap 4. Academic Press, New York, pp 123–134
18. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538–54410.1126/science.1104274 ↗
19. Park B-H, Jung J-C, Lee G-H, Kim T-J, Lee Y-J, Kim J-Y, Kim Y-W, Jeong J-H, Chang Y (2008) Comparison of labeling efficiency of different magnetic nanoparticles into stem cell. Colloid Surf A 313–314:145–14910.1016/j.colsurfa.2007.04.152 ↗
20. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–14710.1126/science.284.5411.143 ↗
21. Seleverstov O, Zabirnyk O, Zscharnack M, Bulavina L, Nowicki M, Heinrich JM, Yezhelyev M, Emmrich F, O’Regan R, Bader A (2006) Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation. Nano Lett 6(12):2826–283210.1021/nl0619711 ↗
22. Shen T, Weissleder R, Papisov M, Bogdanov A Jr, Brady TJ (1993) Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med 29:599–60410.1002/mrm.1910290504 ↗
23. Song H-T, Choi J-S, Huh Y-M, Kim S, Jun Y-W, Suh J-S, Cheon J (2005) Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. J Am Chem Soc 127:9992–999310.1021/ja051833y ↗
24. Veronese FM, Pasut G (2005) Pegylation, successful approach to drug delivery. DDT 10:1451–145810.1016/S1359-6446(05)03575-0 ↗
25. Weissleder R, Stark DD, Engelstad BL et al (1989) Superparamagnetic iron oxide: pharmacokinetics and toxicity. Am J Roentgenol 152:167–17310.2214/ajr.152.1.167 ↗
26. Yang J, Lee T-I, Lee J, Lim E-K, Hyung W, Lee C-H, Song YJ, Suh J-S, Yoon H-G, Huh Y-M, Haam S (2007) Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG–Fatty acid. Chem Mater 19:3870–387610.1021/cm070495s ↗
27. Zhang C, Wangler B, Morgenstern B, Zentgraf H, Eisenhut M, Untenecker H, Kruger R, Huss R, Seliger C, Semmler W, Kiessling F (2007) Silica- and alkoxysilane-coated ultrasmall superparamagnetic iron oxide particles: a promising tool to label cells for magnetic resonance imaging. Langmuir 23:1427–143410.1021/la061879k ↗