Aggregate size and structure determination of nanomaterials in physiological media: importance of dynamic evolution
Source abstract
Abstract
Most in vitro nanotoxicological assays are performed after 24 h exposure. However, in determining size and shape effect of nanoparticles in toxicity assays, initial characterization data are generally used to describe experimental outcome. The dynamic size and structure of aggregates are typically ignored in these studies. This brief communication reports dynamic evolution of aggregation characteristics of gold nanoparticles. The study finds that gradual increase in aggregate size of gold nanospheres (AuNS) occurs up to 6 h duration; beyond this time period, the aggregation process deviates from gradual to a more abrupt behavior as large networks are formed. Results of the study also show that aggregated clusters possess unique structural conformation depending on nominal diameter of the nanoparticles. The differences in fractal dimensions of the AuNS samples likely occurred due to geometric differences, causing larger packing propensities for smaller sized particles. Both such observations can have profound influence on dosimetry for in vitro nanotoxicity analyses.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Afrooz ARMN, Khan IA, Hussain SM, Saleh NB (2013) Mechanistic heteroaggregation of gold nanoparticles in a wide range of solution chemistry. Environ Sci Technol 47:1853–1860. doi: 10.1021/es303270910.1021/es3032709 ↗
2. Afrooz ARM, Sivalapalan ST, Murphy CJ, Hussain SM, Schlager JJ, Saleh NB (2013) Spheres vs. rods: The shape of gold nanoparticles influences aggregation and deposition behavior. Chemosphere 91(1):93–98. doi: 10.1016/j.chemosphere.2012.11.03110.1016/j.chemosphere.2012.11.031 ↗
3. Allison AC (1971) Lysosomes and toxicity of particulate pollutants. Arch Intern Med 128:131. doi: 10.1001/archinte.128.1.13110.1001/archinte.1971.00310190135017 ↗
4. Cho EC, Zhang Q, Xia Y (2011) The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat Nanotechnol 6:385–391. doi: 10.1038/nnano.2011.5810.1038/nnano.2011.58 ↗
5. Clément L, Hurel C, Marmier N (2013) Toxicity of TiO2 nanoparticles to cladocerans, algae, rotifers and plants—Effects of size and crystalline structure. Chemosphere 90:1083–1090. doi: 10.1016/j.chemosphere.2012.09.01310.1016/j.chemosphere.2012.09.013 ↗
6. Hauck TS, Ghazani AA, Chan WC (2008) Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small 4:153–15910.1002/smll.200700217 ↗
7. Kante B et al (1982) Toxicity of polyalkylcyanoacrylate nanoparticles I: Free nanoparticles. J Pharm Sci 71:786–79010.1002/jps.2600710716 ↗
8. Kim TH, Kim M, Park HS, Shin US, Gong MS, Kim HW (2012) Size-dependent cellular toxicity of silver nanoparticles. J Biomed Mater Res Part A 100A:1033–1043. doi: 10.1002/jbm.a.3405310.1002/jbm.a.34053 ↗
9. Lamer VK, Dinegar RH (1950) Theory, production and mechanism of formation of monodispersed hydrosols. J Am Chem Soc 72:4847–4854. doi: 10.1021/ja01167a00110.1021/ja01167a001 ↗
10. Lin MY, Lindsay HM, Weitz DA, Ball RC, Klein R, Meakin P (1989) Universality in colloid aggregation. Nature 339:360–362. doi: 10.1038/339360a010.1038/339360a0 ↗
11. Lison D et al (2008) Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays. Toxicol Sci 104:155–162. doi: 10.1093/toxsci/kfn07210.1093/toxsci/kfn072 ↗
12. Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B (2006) Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2): implications for Nanoparticle Neurotoxicity. Environ Sci Technol 40:4346–4352. doi: 10.1021/es060589n10.1021/es060589n ↗
13. Long TC et al (2007) Nanosize Titanium Dioxide Stimulates Reactive Oxygen Species in Brain Microglia and Damages Neurons in vitro. Environ Health Perspect 115:1631–1637. doi: 10.2307/462698510.1289/ehp.10216 ↗
14. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627. doi: 10.1126/science.111439710.1126/science.1114397 ↗
15. Nel AE et al (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–557. doi: 10.1038/nmat244210.1038/nmat2442 ↗
16. Oberdorster G et al (2005a) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part fibre toxicol 2:8. doi: 10.1186/1743-8977-2-810.1186/1743-8977-2-8 ↗
17. Oberdorster G, Oberdorster E, Oberdorster J (2005b) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839. doi: 10.1289/ehp.733910.1289/ehp.7339 ↗
18. Oberdorster G, Stone V, Donaldson K (2007) Toxicology of nanoparticles: a historical perspective. Nanotoxicology 1:2–25. doi: 10.1080/1743539070131476110.1080/17435390701314761 ↗
19. Pasquini LM, Hashmi SM, Sommer TJ, Elimelech M, Zimmerman JB (2012) Impact of Surface Functionalization on Bacterial Cytotoxicity of Single-Walled Carbon Nanotubes. Environ Sci Technol 46:6297–6305. doi: 10.1021/es300514s10.1021/es300514s ↗
20. Pecora R (1985) Dynamic light scattering: Applications of photon correlation spectroscopy. Springer-Verlag, New York, LLC10.1007/978-1-4613-2389-1 ↗
21. Phenrat T, Saleh N, Sirk K, Kim HJ, Tilton RD, Lowry GV (2008) Stabilization of aqueous nanoscale zerovalent iron dispersions by anionic polyelectrolytes: adsorbed anionic polyelectrolyte layer properties and their effect on aggregation and sedimentation. J Nanoparticle Res 10:795–814. doi: 10.1007/s11051-007-9315-610.1007/s11051-007-9315-6 ↗
22. Potočnik J (2011) Commission Recommendation of 18 October 2011 on the definition of nanomaterial Text with EEA relevance Official. J Eur Union 275:38–40
23. Saleh NB, Pfefferle LD, Elimelech M (2010) Influence of biomacromolecules and humic acid on the aggregation kinetics of single-walled carbon nanotubes. Environ Sci Technol 44:2412–2418. doi: 10.1021/es903059t10.1021/es903059t ↗
24. Schulze C et al (2008) Not ready to use—overcoming pitfalls when dispersing nanoparticles in physiological media. Nanotoxicology 2:51–61. doi: 10.1080/1743539080201837810.1080/17435390802018378 ↗
25. Shields SP, Richards VN, Buhro WE (2010) Nucleation control of size and dispersity in aggregative nanoparticle growth. A study of the coarsening kinetics of thiolate-capped gold nanocrystals. Chem Mater 22:3212–3225. doi: 10.1021/cm100458b10.1021/cm100458b ↗
26. Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M (2005) Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–1065410.1021/la0513712 ↗
27. Weitz DA, Oliveria M (1984) Fractal structures formed by kinetic aggregation of aqueous gold colloids. Phys Rev Lett 52:1433–1436. doi: 10.1103/PhysRevLett.52.143310.1103/PhysRevLett.52.1433 ↗
28. Wiogo HTR, Lim M, Bulmus V, Amal R Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum. In: Nanotechnology (IEEE-NANO), 2011 11th IEEE Conference on, 15–18 August 2011. pp 841–844 doi:z 10.1109/nano.2011.614449910.1109/NANO.2011.6144499 ↗
29. Wu H, Lattuada M, Morbidelli M (2013) Dependence of fractal dimension of DLCA clusters on size of primary particles. Adv Colloid Interface Sci 195:41. doi: 10.1016/j.cis.2013.04.00110.1016/j.cis.2013.04.001 ↗
30. Zhou D, Keller AA (2010) Role of morphology in the aggregation kinetics of ZnO nanoparticles. Water Res 44:2948–2956. doi: 10.1016/j.watres.2010.02.02510.1016/j.watres.2010.02.025 ↗