journal article·2025-09

Staphylococcus aureus–directed liposome for targeted chemotherapy against infection—evaluation of affinity and antibacterial activity

Koki Ogawa, Ayumi Nishi, Naoki Umezawa, Tsunehiko Higuchi, Tetsuya Ozeki

Journal of Nanoparticle Research· Volume 27· Issue 9
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Abstract

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Research context

OpenAlex topics: Antimicrobial Peptides and Activities · Inhalation and Respiratory Drug Delivery · Advanced Drug Delivery Systems

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References (24)

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1. Cilloniz C et al (2023) World pneumonia day 2023: the rising global threat of pneumonia and what we must do about it. Eur Respir J 62(5):230167210.1183/13993003.01672-2023 ↗
2. Wang D et al (2025) Virulence factors in biofilm formation and therapeutic strategies for Staphylococcus aureus: a review. Animals and Zoonoses 1(2):188–20210.1016/j.azn.2024.11.003 ↗
3. Kaushik A et al (2024) Biofilm producing methicillin-resistant Staphylococcus aureus (MRSA) infections in humans: clinical implications and management. Pathogens 13(1):7610.3390/pathogens13010076 ↗
4. Idrees M et al (2021) Staphylococcus aureus biofilm: morphology, genetics, pathogenesis and treatment strategies. Int J Environ Res Public Health 18(14):760210.3390/ijerph18147602 ↗
5. Zhang J et al (2018) Amikacin liposome inhalation suspension (ALIS) penetrates non-tuberculous mycobacterial biofilms and enhances amikacin uptake into macrophages. Front Microbiol 9:91510.3389/fmicb.2018.00915 ↗
6. Guo Y et al (2023) Nanotechnology-based drug delivery systems to control bacterial-biofilm-associated lung infections. Pharmaceutics. https://doi.org/10.3390/pharmaceutics1511258210.3390/pharmaceutics15112582 ↗
7. Nikolaizik WH, Trociewicz K, Ratjen F (2002) Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis. Eur Respir J 20(1):122–12610.1183/09031936.02.00264002 ↗
8. Aronson MR, Medina SH, Mitchell MJ (2021) Peptide functionalized liposomes for receptor targeted cancer therapy. APL Bioeng 5(1):01150110.1063/5.0029860 ↗
9. Gu Z et al (2020) Liposome-based drug delivery systems in cancer immunotherapy. Pharmaceutics. https://doi.org/10.3390/pharmaceutics1211105410.3390/pharmaceutics12111054 ↗
10. Hussain S et al (2018) Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy. Nat Biomed Eng 2(2):95–10310.1038/s41551-017-0187-5 ↗
11. Jiang J et al (2022) Staphylococcus aureus-targeting peptide/surfactant assemblies for antibacterial therapy. Colloids Surf B Biointerfaces 214:11244410.1016/j.colsurfb.2022.112444 ↗
12. Ye Y et al (2011) Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging. Bioorg Med Chem Lett 21(4):1146–115010.1016/j.bmcl.2010.12.112 ↗
13. Piraube C et al (1988) Evidence of chemical instability of phospholipids in liposomes. Chem Pharm Bull 36(11):4600–460210.1248/cpb.36.4600 ↗
14. Rinaldi F et al (2021) Rifampicin–liposomes for Mycobacterium abscessus infection treatment: intracellular uptake and antibacterial activity evaluation. Pharmaceutics 13(7):107010.3390/pharmaceutics13071070 ↗
15. Moreira JN et al (2002) Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity. Pharm Res 19(3):265–26910.1023/A:1014434732752 ↗
16. Ibaraki H et al (2020) The effects of surface properties of liposomes on their activity against Pseudomonas aeruginosa PAO-1 biofilm. J Drug Deliv Sci Technol 57:10175410.1016/j.jddst.2020.101754 ↗
17. Kawano K, Maitani Y (2011) Effects of polyethylene glycol spacer length and ligand density on folate receptor targeting of liposomal doxorubicin in vitro. J Drug Deliv. https://doi.org/10.1155/2011/16096710.1155/2011/160967 ↗
18. Mashreghi M et al (2024) Enhancing the potency of anti-P32-active targeted PEGylated liposomal doxorubicin using various spacers: in silico, in vitro and in vivo studies. J Drug Deliv Sci Technol 101:10623310.1016/j.jddst.2024.106233 ↗
19. Yamamoto S, Sakurai Y, Harashima H (2018) Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption. Int J Pharm 536(1):42–4910.1016/j.ijpharm.2017.11.010 ↗
20. Shmendel E et al (2020) Effects of spacers within a series of novel folate-containing lipoconjugates on the targeted delivery of nucleic acids. J Drug Deliv Sci Technol 57:10160910.1016/j.jddst.2020.101609 ↗
21. Suga T et al (2017) Ligand peptide-grafted PEGylated liposomes using HER2 targeted peptide-lipid derivatives for targeted delivery in breast cancer cells: the effect of serine-glycine repeated peptides as a spacer. Int J Pharm 521(1–2):361–36410.1016/j.ijpharm.2017.02.041 ↗
22. Maruyama K et al (1995) Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies. Biochimica et Biophysica Acta (BBA) 1234(1):74–8010.1016/0005-2736(94)00263-O ↗
23. Changsan N et al (2009) Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation. J Pharm Sci 98(2):628–63910.1002/jps.21441 ↗
24. Ma Y et al (2013) Enhanced bactericidal potency of nanoliposomes by modification of the fusion activity between liposomes and bacterium. Int J Nanomedicine 8(1):2351–236010.2147/IJN.S42617 ↗