Synthesis of Au nanoparticles coated with silica containing polyethylene glycol for extracorporeally dischargeable X-ray contrast agents
Source abstract
Abstract
This work proposes a method for fabricating nanoparticles composed of gold (Au) nanoparticles and silica shells containing polyethylene glycol (PEG) (Au/SiO2(PEG)) for diagnostic imaging. The proposed method involves two steps. The first step is the synthesis of Au nanoparticles. The synthesis of Au nanoparticles with a diameter of 2.2 ± 0.4 nm was performed with a reduction of hydrogentetrachloroaurate (III) trihydrate with tetrakis (hydroxymethyl) phosphonium chloride in a sodium hydroxide (NaOH) aqueous solution. In the second step, the Au nanoparticles are coated in silica while in the presence of PEG. The silica coating was produced by a sol–gel reaction of tetraethylorthosilicate in the presence of Au nanoparticles and PEG in water/ethanol dissolving NaOH. The Au/SiO2(PEG) nanoparticles degraded faster and in larger quantities in bovine calf serum/phosphate-buffered saline solution than silica-coated Au nanoparticles fabricated in the absence of PEG and had an X-ray imaging ability. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications · Laser-Ablation Synthesis of Nanoparticles
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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