Acrylic polymer nanoparticles: cytotoxicity, cell permeability, and biodistribution in mice after intravenous injection
Source abstract
Abstract
Polymer nanoparticles are promising candidates for drug encapsulation and drug delivery systems. Particle surface functionalization allows for targeting specific sites, improving the drug distribution and hence potentializing the treatment of a wide range of diseases. In the present work, both the ability of polymeric nanoparticles to cross tissue membranes in Caco-2 cell cultures and the nanoparticle distribution among different tissues after intravenous infusion in mice are analyzed. Poly(methyl methacrylate-co-acrylic acid) and poly(methyl methacrylate-co-methacrylic acid) nanoparticles were prepared through miniemulsion polymerizations and functionalized with a fluorescence dye through covalent bonding. Cytotoxic effects were not observed in concentrations below of 1689 µg/mL for methacrylic particles and 2411 µg/mL for acrylic particles. Half-lives of nanoparticle circulation in animals were short, as particles were removed from the bloodstream after 30 min. Fluorescence analyses showed that polymer nanoparticles can reach different organs with very heterogeneous distributions, reaching maximum concentration in the kidneys. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Drug Delivery Systems · Advanced Polymer Synthesis and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (61)
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