High drug loading capacity of UiO-69 metal–organic framework with linkers 2,6-naphthalenedicarboxylic acid with carboplatin
Source abstract
Abstract
The encapsulation of therapeutic drugs in drug delivery containers as metal–organic frameworks (MOFs) has the potential to enhance the effectiveness of chemotherapy. The drug loading capacity of the nanoscale UiO-69 MOF has been investigated by encapsulating carboplatin (CarboPt), a therapeutic agent, within the MOF structure. A UiO-69@CarboPt nanocomposite was synthesized using a one-pot technique, in which carboplatin was encapsulated within the UiO-69 MOF structure. Advanced analytical techniques, such as X-ray diffraction (XRD), X-ray fluorescence (XRF), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Raman spectroscopy, and UV–Vis spectroscopy, were employed to examine the structural characteristics, morphology, and atomic structure of the nanocomposite. The study observed that the nanoscale UiO-69 MOF with 2,6-naphthalenedicarboxylic acid as an organic linker had a significantly increased loading capacity due to linker lengthening, as well as the MOF’s unique morphology, contributed to this increased drug loading capacity. Drug release studies in phosphate-buffered saline (PBS) at 37 °C demonstrate a controlled release profile for UiO-69@Pt4, with 30% release after 3 h and 76% after 24 h. The carboplatin-encapsulated UiO-69 MOF nanocomposite holds potential for biomedical applications, particularly in drug delivery and chemotherapy. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · X-ray Diffraction in Crystallography · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
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