NIR-II-responsive CuMo2S3 superstructures for phototherapy and chemodynamic therapy of cancer
Source abstract
Abstract
Second near-infrared (NIR-II; 1000–1400 nm) induced photothermal therapy (PTT) has recently become a research focus as an emerging candidate for cancer therapeutic modality, owing to the advantages of minimal invasiveness, less energy dissipation, and deeper tissue penetration depth in comparison to traditional PTT with first near-infrared (NIR-I; 700–1000 nm) irradiation. Herein, an efficient nanoagent was firstly fabricated based on CuMo2S3 materials, which is capable to generate hyperthermia and reactive oxygen species (ROS) under NIR-II light stimulation. The harboring multivalent elements (Cu1+/2+, Mo4+/6+) can also perform chemodynamic therapy (CDT) due to the Fenton-like reaction and subsequently enhance therapeutic efficiency. The PEGylated CuMo2S3 nanoparticles (CMS NPs) react with the excess H2O2 of tumor microenvironment (TME) with a catalase-like reaction, which can generate hydroxyl radicals (•OH) for CDT and release O2 to relieve hypoxia level. The dandelion-like nanostructure exhibited excellent photothermal conversion efficiency (38.2%) as well as outstanding particle morphology stability after the in vitro test. Besides, the CMS NPs demonstrated great enhancement in anticancer efficiency, as well as good biocompatibility, hyperthermal effect, and excellent photodynamic therapy (PDT) performance, upon the 1064-nm NIR-II laser irradiation. These outcomes suggest the promising potential of the CMS NPs against cancer therapeutic with excellent clinical translation promises.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Advanced Photocatalysis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (64)
Show source-provided references
1. Lyu Y, Li JC, Pu K (2019) Second near-infrared absorbing agents for photoacoustic imaging and photothermal therapy. Small Methods 3(11):190055310.1002/smtd.201900553 ↗
2. Liu YJ, Bhattarai P, Dai ZF, Chen XY (2019) Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev 48:2053–210810.1039/C8CS00618K ↗
3. Wang Q, Dai YN, Xu JZ, Cai J, Niu XR, Zhang L, Chen RF, Shen QM, Huang W, Fan QL (2019) All-in-one phototheranostics: single laser triggers NIR-II fluorescence/photoacoustic imaging guided photothermal/photodynamic/chemo combination therapy. Adv Funct Mater 29:190148010.1002/adfm.201901480 ↗
4. Melancon MP, Zhou M, Li C (2011) Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Accounts Chem Res 44:947–95610.1021/ar200022e ↗
5. Wang YC, Black KCL, Luehmann H, Li WY, Zhang Y, Cai X, Wan DH, Liu SY, Li M, Kim P, Li ZY, Wang LHV, Liu YJ, Xia YA (2013) Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. ACS Nano 7:2068–207710.1021/nn304332s ↗
6. Zhang YJ, Sha R, Zhang L, Zhang WB, Jin PP, Xu WG, Ding JX, Lin J, Qian J, Yao GY, Zhang R, Luo FC, Zeng J, Cao J, Wen LP (2018) Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer. Nat Commun 910.1038/s41467-018-06529-y ↗
7. Yang JX, Su HL, Sun WS, Cai JL, Liu SY, Chai YM, Zhang CF (2018) Dual chemodrug-loaded single-walled carbon nanohorns for multimodal imaging-guided chemo-photothermal therapy of tumors and lung metastases. Theranostics 8:1966–198410.7150/thno.23848 ↗
8. Song JB, Yang XY, Jacobson O, Lin LS, Huang P, Niu G, Ma QJ, Chen XY (2015) Sequential drug release and enhanced photothermal and photoacoustic effect of hybrid reduced graphene oxide-loaded ultrasmall gold nanorod vesicles for cancer therapy. ACS Nano 9:9199–920910.1021/acsnano.5b03804 ↗
9. Usama SM, Thavornpradit S, Burgess K (2018) Optimized heptamethine cyanines for photodynamic therapy. ACS Appl Bio Mater 1:1195–120510.1021/acsabm.8b00414 ↗
10. Tan X, Luo SL, Long L, Wang Y, Wang DC, Fang ST, Ouyang Q, Su YP, Cheng TM, Shi CM (2017) Structure-guided design and synthesis of a mitochondria-targeting near-infrared fluorophore with multimodal therapeutic activities. Adv Mater 2910.1002/adma.201704196 ↗
11. Atchison J, Kamila S, Nesbitt H, Logan KA, Nicholas DM, Fowley C, Davis J, Callan B, McHale AP, Callan JF (2017) Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT). Chem Commun 53:2009–201210.1039/C6CC09624G ↗
12. Bian H, Ma DD, Zhang XF, Xin K, Yang YJ, Peng XJ, Xiao Y (2021) Tailored engineering of novel xanthonium polymethine dyes for synergetic PDT and PTT triggered by 1064 nm laser toward deep-seated tumors. Small 1710.1002/smll.202100398 ↗
13. Tian QW, Jiang FR, Zou RJ, Liu Q, Chen ZG, Zhu MF, Yang SP, Wang JL, Wang JH, Hu JQ (2011) Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 5:9761–977110.1021/nn203293t ↗
14. Lyu Y, Zeng JF, Jiang YY, Zhen X, Wang T, Qiu SS, Lou X, Gao MY, Pu KY (2018) Enhancing both biodegradability and efficacy of semiconducting polymer nanoparticles for photoacoustic imaging and photothermal therapy. ACS Nano 12:1801–181010.1021/acsnano.7b08616 ↗
15. Lin TY, Li YP, Liu QQ, Chen JL, Zhang HY, Lac D, Zhang H, Ferrara KW, Wachsmann-Hogiu S, Li TH, Airhart S, White RD, Lam KS, Pan CX (2016) Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer. Biomaterials 104:339–35110.1016/j.biomaterials.2016.07.026 ↗
16. Zhen X, Cheng PH, Pu KY (2019) Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy. Small 1510.1002/smll.201804105 ↗
17. Gan N, Wang X, Ma HL, Lv AQ, Wang H, Wang Q, Gu MX, Cai SZ, Zhang YY, Fu LS, Zhang M, Dong CM, Yao W, Shi HF, An ZF, Huang W (2019) Manipulating the stacking of triplet chromophores in the crystal form for ultralong organic phosphorescence. Angew Chem Int Ed 58:14140–1414510.1002/anie.201907572 ↗
18. Ke CS, Fang CC, Yan JY, Tseng PJ, Pyle JR, Chen CP, Lin SY, Chen JX, Zhang XJ, Chan YH (2017) Molecular engineering and design of semiconducting polymer dots with narrow-band, near-infrared emission for in vivo biological imaging. ACS Nano 11:3166–317710.1021/acsnano.7b00215 ↗
19. Alifu N, Zebibula A, Qi J, Zhang HQ, Sun CW, Yu XM, Xue DW, Lam JWY, Li GH, Qian J, Tang BZ (2018) Single-molecular near-infrared-II theranostic systems: ultrastable aggregation-induced emission nanoparticles for long-term tracing and efficient photothermal therapy. ACS Nano 12:11282–1129310.1021/acsnano.8b05937 ↗
20. Cheng L, Jiang DW, Kamkaew A, Valdovinos HF, Im HJ, Feng LZ, England CG, Goel S, Barnhart TE, Liu Z, Cai WB (2017) Renal-clearable PEGylated porphyrin nanoparticles for image-guided photodynamic cancer therapy. Adv Funct Mater 2710.1002/adfm.201702928 ↗
21. Wang R, Zhou L, Wang WX, Li XM, Zhang F (2017) In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers. Nat Commun 810.1038/ncomms14702 ↗
22. Zhao YX, Pan HC, Lou YB, Qiu XF, Zhu JJ, Burda C (2009) Plasmonic Cu2 − xS nanocrystals: optical and structural properties of copper-deficient copper(I) sulfides. J Am Chem Soc 131:4253–426110.1021/ja805655b ↗
23. Luther JM, Jain PK, Ewers T, Alivisatos AP (2011) Localized surface plasmon resonances arising from free carriers in doped quantum dots. Nat Mater 10:361–36610.1038/nmat3004 ↗
24. Zhang H, Wang TT, Qiu WB, Han YB, Sun Q, Zeng JF, Yan F, Zheng HR, Li Z, Gao MY (2018) Monitoring the opening and recovery of the blood-brain barrier with noninvasive molecular imaging by biodegradable ultrasmall Cu2 − xSe nanoparticles. Nano Lett 18:4985–499210.1021/acs.nanolett.8b01818 ↗
25. Zhang SH, Sun CX, Zeng JF, Sun Q, Wang GL, Wang Y, Wu Y, Dou SX, Gao MY, Li Z (2016) Ambient aqueous synthesis of ultrasmall PEGylated Cu2 − xSe nanoparticles as a multifunctional theranostic agent for multimodal imaging guided photothermal therapy of cancer. Adv Mater 28:8927–893610.1002/adma.201602193 ↗
26. Li B, Ye KC, Zhang YX, Qin JB, Zou RJ, Xu KB, Huang XJ, Xiao ZY, Zhang WJ, Lu XW, Hu JQ (2015) Photothermal theragnosis synergistic therapy based on bimetal sulphide nanocrystals rather than nanocomposites. Adv Mater 27:1339–134510.1002/adma.201404257 ↗
27. Huang XJ, Deng GY, Liao LJ, Zhang WL, Guan GQ, Zhou F, Xiao ZY, Zou RJ, Wang Q, Hu JQ (2017) CuCo2S4 nanocrystals: a new platform for multi-modal imaging guided photothermal therapy. Nanoscale 9:2626–263210.1039/C6NR09028A ↗
28. Zhang K, Chen WX, Wang Y, Li J, Chen HP, Gong ZY, Chang S, Ye F, Wang TX, Chu WS, Zou CW, Song L (2015) Cube-like Cu2MoS4 photocatalysts for visible light-driven degradation of methyl orange. Aip Adv 510.1063/1.4926923 ↗
29. Chen WX, Chen HP, Zhu HT, Gao QQ, Luo J, Wang Y, Zhang S, Zhang K, Wang CM, Xiong YJ, Wu YF, Zheng XS, Chu WS, Song L, Wu ZY (2014) Solvothermal synthesis of ternary Cu2MoS4 nanosheets: structural characterization at the atomic level. Small 10:4637–464410.1002/smll.201400752 ↗
30. Zhou J, Li MH, Hou YH, Luo Z, Chen QF, Cao HX, Huo RL, Xue CC, Sutrisno L, Hao L, Cao Y, Ran HT, Lu L, Li K, Cai KY (2018) Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy. ACS Nano 12:2858–287210.1021/acsnano.8b00309 ↗
31. An L, Wang X, Rui X, Lin J, Yang H, Tian Q, Tao C, Yang S (2018) The in situ sulfidation of Cu2O by endogenous H2S for colon cancer theranostics. Angew Chem Int Ed 57:15782–1578610.1002/anie.201810082 ↗
32. Yang X, Yang Y, Gao F, Wei JJ, Qian CG, Sun MJ (2019) Biomimetic hybrid nanozymes with self-supplied H+ and accelerated O2 generation for enhanced starvation and photodynamic therapy against hypoxic tumors. Nano Lett 19:4334–434210.1021/acs.nanolett.9b00934 ↗
33. Wang, Y. K., Cai, D. D., Wu, H. X., Fu, Y., Cao, Y., Zhang, Y. J., Wu, D. M., Tian, Q. W., and Yang, S. P. (2018) Functionalized Cu3BiS3 nanoparticles for dual-modal imaging and targeted photothermal/photodynamic therapy, Nanoscale 10, 4452-4462.10.1039/C7NR07458A ↗
34. Chang M, Wang M, Wang M, Shu M, Ding B, Li C, Pang M, Cui S, Hou Z, Lin J (2019) A multifunctional cascade bio reactor based on hollow-structured Cu2MoS4 for synergetic cancer chemo-dynamic therapy/starvation therapy/phototherapy/immunotherapy with remarkably enhanced efficacy. Adv Mater 31:1905271.1905271–1905271.1905210
35. Chen JW, Mohrhusen L, Ali G, Li SH, Chung KY, Al-Shamery K, Lee PS (2019) Electrochemical mechanism investigation of Cu2MoS4 hollow nanospheres for fast and stable sodium ion storage. Adv Funct Mater 2910.1002/adfm.201807753 ↗
36. Zhou JM, Xu G, Zhang ZW, Wang HY (2019) Facile synthesis of Cu2MoS4 nanosheet/multi-walled carbon nanotube composites as a high-efficiency electrocatalyst for hydrogen evolution. New J Chem 43:9574–958210.1039/C9NJ01468C ↗
37. Chang M, Wang M, Wang M, Shu M, Ding B, Li C, Pang M, Cui S, Hou Z, Lin J (2019) A multifunctional cascade bioreactor based on hollow-structured Cu2MoS4 for synergetic cancer chemo-dynamic therapy/starvation therapy/phototherapy/immunotherapy with remarkably enhanced efficacy. Adv Mater 31:190527110.1002/adma.201905271 ↗
38. Ji M, Xu M, Zhang W, Yang Z, Huang L, Liu J, Zhang Y, Gu L, Yu Y, Hao W (2016) Structurally well-defined Au@ Cu2 − xS core–shell nanocrystals for improved cancer treatment based on enhanced photothermal efficiency. Adv Mater 28:3094–310110.1002/adma.201503201 ↗
39. Moulder JF, Chastain J, King RC (1992) Handbook of X-ray photoelectron spectroscopy: a reference book of standard spectra for identification and interpretation of XPS data. Chem Phys Lett 220:7–10
40. Chang JY, Lin JM, Su LF, Chang CF (2013) Improved performance of CuInS2 quantum dot-sensitized solar cells based on a multilayered architecture. ACS Appl Mater Interfaces 5:8740–875210.1021/am402547e ↗
41. Shenoy US, Shetty AN (2014) Simple glucose reduction route for one-step synthesis of copper nanofluids. Appl Nanosci 4:47–5410.1007/s13204-012-0169-6 ↗
42. Chen WF, Wang CH, Sasaki K, Marinkovic N, Xu W, Muckerman JT, Zhu Y, Adzic RR (2013) Highly active and durable nanostructured molybdenum carbide electrocatalysts for hydrogen production. Energy Environ Sci 6:943–95110.1039/c2ee23891h ↗
43. Li B, Zhang YX, Zou RJ, Wang Q, Zhang BJ, An L, Yin F, Hua YQ, Hu JQ (2014) Self-assembled WO3 − x hierarchical nanostructures for photothermal therapy with a 915 nm laser rather than the common 980 nm laser. Dalton Trans 43:6244–625010.1039/c3dt53396d ↗
44. Roper DK, Ahn W, Hoepfner M (2007) Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles. J Phys Chem C 111:3636–364110.1021/jp064341w ↗
45. Li XS, Lovell JF, Yoon J, Chen XY (2020) Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol 17:657–67410.1038/s41571-020-0410-2 ↗
46. Huang Z, Liu XJ, Deng GY, Yuan HK, Wang QG, Zhang LJ, Lu J (2018) One-step assembly of CuMo2S3 nanocrystals for the synergistic effect of photothermal therapy and photodynamic therapy. Dalton Trans 47:5622–562910.1039/C7DT04901C ↗
47. Deng KR, Hou ZY, Deng XR, Yang PP, Li CX, Lin J (2015) Enhanced antitumor efficacy by 808 nm laser-induced synergistic photothermal and photodynamic therapy based on a indocyanine-green-attached W18O49 nanostructure. Adv Funct Mater 25:7280–729010.1002/adfm.201503046 ↗
48. Zhu TC, Finlay JC, Zhou XD, Li J (2007) Macroscopic modeling of the singlet oxygen production during PDT. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy Xvi, vol 6427. SPIE, pp 57–68
49. Liu BC, Farrell TJ, Patterson MS (2011) A dynamic model for ALA-PDT of skin: analysis of the correlation of fluorescence and singlet oxygen luminescence to spatial distribution of singlet oxygen. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy Xx, vol 7886. SPIE, pp 74–80
50. Liu BC, Kim MM, Zhu TC (2013) A theoretical comparison of macroscopic and microscopic modeling of singlet oxygen during Photofrin and HPPH mediated-PDT. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy Xxii, vol 8568. SPIE, pp 25–36
51. Lv G, Guo W, Zhang W, Zhang T, Li S, Chen S, Eltahan AS, Wang D, Wang Y, Zhang J (2016) Near-infrared emission CuInS/ZnS quantum dots: all-in-one theranostic nanomedicines with intrinsic fluorescence/photoacoustic imaging for tumor phototherapy. ACS nano 10:9637–964510.1021/acsnano.6b05419 ↗
52. Yuan Z, Tao B, He Y, Liu J, Lin C, Shen X, Ding Y, Yu Y, Mu C, Liu P (2019) Biocompatible MoS2/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation. Biomaterials 217:11929010.1016/j.biomaterials.2019.119290 ↗
53. Li M, Wang Y, Lin H, Qu F (2019) Hollow CuS nanocube as nanocarrier for synergetic chemo/photothermal/photodynamic therapy. Mater Sci Eng C 96:591–59810.1016/j.msec.2018.11.020 ↗
54. Song CQ, Yang CY, Wang F, Ding DD, Gao Y, Guo W, Yan M, Liu SQ, Guo CS (2017) MoS2-Based multipurpose theranostic nanoplatform: realizing dual-imaging-guided combination phototherapy to eliminate solid tumor via a liquefaction necrosis process. J Mater Chem B 5:9015–902410.1039/C7TB02648J ↗
55. Li LH, Rashidi LH, Yao MY, Ma L, Chen LL, Zhang JY, Zhang Y, Chen W (2017) CuS nanoagents for photodynamic and photothermal therapies: phenomena and possible mechanisms. Photodiagnosis Photodyn Ther 19:5–1410.1016/j.pdpdt.2017.04.001 ↗
56. Yu SH, Lee Y, Jang SK, Kang J, Jeon J, Lee C, Lee JY, Kim H, Hwang E, Lee S, Cho JH (2014) Dye-sensitized MoS2 photodetector with enhanced spectral photoresponse. ACS Nano 8:8285–829110.1021/nn502715h ↗
57. Wang ZY, von dem Bussche A, Kabadi PK, Kane AB, Hurt RH (2013) Biological and environmental transformations of copper-based nanomaterials. ACS Nano 7:8715–872710.1021/nn403080y ↗
58. Yao C, Qi H, Jia X, Xu Y, Tong Z, Gu Z, Yang D (2022) A DNA nanocomplex containing cascade DNAzymes and promoter-like Zn-Mn-ferrite for combined gene/chemo-dynamic therapy. Angew Chem Int Ed 61:e20211361910.1002/anie.202113619 ↗
59. Lucky SS, Soo KC, Zhang Y (2015) Nanoparticles in photodynamic therapy. Chem Reviews 115:1990–204210.1021/cr5004198 ↗
60. Ali M, Rahman MA, Wu Y, Han T, Peng X, Mackey MA, Wang D, Shin HJ, Chen ZG, Xiao H (2017) Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice. Proc Natl Acad Sci USA 114:E3110
61. Xing YF, Cai ZW, Xu MJ, Ju WZ, Luo XJ, Hu YJ, Liu XY, Kang TL, Wu P, Cai CX, Zhu JJ (2019) Raman observation of a molecular signaling pathway of apoptotic cells induced by photothermal therapy. Chem Sci 10:10900–1091010.1039/C9SC04389F ↗
62. Zhu R, Gao F, Piao JG, Yang LH (2017) Skin-safe photothermal therapy enabled by responsive release of acid-activated membrane-disruptive polymer from polydopamine nanoparticle upon very low laser irradiation. Biomater Sci 5:1596–160210.1039/C7BM00256D ↗
63. Wang Y, Wei GQ, Zhang XB, Huang XH, Zhao JY, Guo X, Zhou SB (2018) Multistage targeting strategy using magnetic composite nanoparticles for synergism of photothermal therapy and chemotherapy. Small 1410.1002/smll.201702994 ↗
64. Rampa DR, Ko C, Lee Y, Lee D (2021) NIR dye-conjugated maltodextrin for photothermal therapy of cancer. Macromol Res 29:306–31210.1007/s13233-021-9038-z ↗