Selective detection of folate and analogs employing highly luminescent manganese-nitrogen co-doped carbon quantum dots: a fluorimetric turn-off strategy
Source abstract
Abstract
Facile detection of folate and analog by following the luminescence quenching of newly synthesized manganese-nitrogen co-doped carbon dots has been highlighted. Here, we devised, for the first time, water-dispersible manganese-nitrogen co-doped carbon dots from branched polyethyleneimine, manganese chloride, and citrate. The developed quantum dots emit bright blue fluorescence with a quantum yield of ~ 0.37. These show sensitive and selective fluorescence quenching by folates with a low limit of detection. The real samples with folate yield reproducible results, and coexistent molecules other than those belonging to the folate family did not cause any detectable change in the luminescence of quantum dots. Hence, the developed manganese-nitrogen co-doped carbon dots–based sensing strategy can offer a convenient and label-free protocol for the detection and quantification of folates in real samples and microorganisms. Graphical Abstract Highly luminescent Mn-, N-CQDs show fluorometric sensitivity toward folic acid in real food sample.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (63)
Show source-provided references
1. Zhang JR, Wang ZL, Qu F, Luo HQ, Li NB (2014) Polyethylenimine-capped silver nanoclusters as a fluorescence probe for highly sensitive detection of folic acid through a two-step electron-transfer process. Journal of Agricultural and Food Chemistry.https://doi.org/10.1021/jf405453410.1021/jf4054534 ↗
2. Xiao F, Ruan C, Liu L, Yan R, Zhao F, Zeng B (2008) Single-walled carbon nanotube-ionic liquid paste electrode for the sensitive voltammetric determination of folic acid. Sens Actuators B: Chem. https://doi.org/10.1016/j.snb.2008.06.03710.1016/j.snb.2008.06.037 ↗
3. Maiyalagan T, Sundaramurthy J, Kumar PS, Kannan P, Opallo M, Ramakrishna S (2013) Nanostructured α-Fe2O3 platform for the electrochemical sensing of folic acid. Anal. https://doi.org/10.1039/C3AN00070B10.1039/C3AN00070B ↗
4. Akbar S, Anwar A, Kanwal Q (2016) Electrochemical determination of folic acid: a short review. Anal Biochem. https://doi.org/10.1016/j.ab.2016.07.00210.1016/j.ab.2016.07.002 ↗
5. Chekin F, Teodorescu F, Coffinier Y, Pan GH, Barras A, Boukherroub R, Szunerits S (2016) MoS2/reduced graphene oxide as active hybrid material for the electrochemical detection of folic acid in human serum. Biosens Bioelectron. https://doi.org/10.1016/j.bios.2016.05.09510.1016/j.bios.2016.05.095 ↗
6. Pellis L, Dommels Y, Venema D, Polanen A, Lips E, Baykus H, Kok F, Kampman E, Keijer J (2008) High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Bri J Nutr. https://doi.org/10.1017/S000711450782414710.1017/S0007114507824147 ↗
7. Chen X, Zhu X, Xu Z, Xu M, Wen Y, Liu Y, Lui J, Oin X (2019) Target hexagonal Pdnanosheet combination therapy for rheumatoid arthritis via the photothermal controlled release of MTX. J Mater Chem B. https://doi.org/10.1039/C8TB02302F10.1039/C8TB02302F ↗
8. Sarkar C, Chowdhuri AR, Kumar A, Laha D, Garai S, Chakraborty J, Sahu SK (2018) One pot synthesis of carbon dots decorated carboxymethyl cellulose-hydroxyapatite nanocomposite for drug delivery, tissue engineering and Fe3+ ion sensing. CarbohydrPolym. https://doi.org/10.1016/j.carbpol.2017.11.09110.1016/j.carbpol.2017.11.091 ↗
9. Chaudhary S, Umar A, Bhasin K, Singh BN (2017) Applications of carbon dots in nanomedicine. J Biomed Nanotechnolhttps://doi.org/10.1166/jbn.2017.239010.1166/jbn.2017.2390 ↗
10. Wang TY, Chen CY, Wang CM, Tan YZ, Liao WS (2017) Multicolor functional carbon dots via one-step refluxing synthesis. ACS Sens. https://doi.org/10.1021/acssensors.6b0060710.1021/acssensors.6b00607 ↗
11. Wang Y, Lu L, Peng H, Xu J, Wang F, Qi R, Xu Z, Zhang W (2016) Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions. ChemCommun. https://doi.org/10.1039/C6CC02874H10.1039/C6CC02874H ↗
12. Xu Q, Su R, Chen Y, TheruvakkattilSreenivasan S, Li N, Zheng X, Zhu J, Pan H (2018) Metal charge transfer doped carbon dots with reversibly switchable, ultra-high quantum yield photoluminescence. App Nano Mater. https://doi.org/10.1021/acsanm.8b0027710.1021/acsanm.8b00277 ↗
13. Molkenova A, Atabaev T. Phosphorus-doped carbon dots (P-CDs) from dextrose for low-concentration ferric ions sensing in water. Acs Omega. https://doi.org/10.1016/j.ijleo.2019.05.01310.1016/j.ijleo.2019.05.013 ↗
14. Li M, Chen T, Gooding J J, Liu J (2019) Review of carbon and graphene dots for sensing. ACS Sens. https://doi.org/10.1021/acssensors.9b0051410.1021/acssensors.9b00514 ↗
15. Tajik S, Dourandish Z, Zhang K, Beitollahi H, Le Q V, Jang H W, Shokouhimehr M (2020) RSC Advances. https://doi.org/10.1039/D0RA00799D10.1039/D0RA00799D ↗
16. Tang M, Ren G, Zhu B, Yu L, Liu X, Chai F, Wu H (2019) Facile synthesis of orange emissive carbon dots and their application for mercury ion detection and fast fingerprint development. Anal Methods. https://doi.org/10.1039/C9AY00178F10.1039/C9AY00178F ↗
17. Atchudan R, Edison TNJI, Aseer KR, Perumal S, Karthik N, Lee JB (2018) Highly fluorescent nitrogen-doped carbon dots derived from Phyllanthus acidus utilized as a fluorescent probe for label-free selective detection of Fe3+ ions, live cell imaging and fluorescent ink. Biosens Bioelctronics. https://doi.org/10.1016/j.bios.2017.07.076.10.1016/j.bios.2017.07.076 ↗
18. Zhang H, Ming H, Lian S, Huang H, Li H, Zhang L, Liu Y, Kang Z (2011) Fe 2 O 3/carbon quantum dots complex photocatalysts and their enhanced photocatalytic activity under visible light. Dalton Trans. https://doi.org/10.1039/C1DT11147G10.1039/C1DT11147G ↗
19. Guo Y, Zhang J, Zhou D, Dong ML (2018) Fabrication of Ag/CDots/BiOBr ternary photocatalyst with enhanced visible-light driven photocatalytic activity for 4-chlorophenol degradation. J Mol Liq. https://doi.org/10.1016/j.molliq.2018.04.09110.1016/j.molliq.2018.04.091 ↗
20. Kumari R, Kumar Sahu JC (2018) Synthesis of longer‐wavelength‐emissive carbon quantum dots for WLEDs and investigation of their photoluminescence properties. Chem Sel. https://doi.org/10.1002/slct.20180263710.1002/slct.201802637 ↗
21. Sun C, Zhang Y, Kalytchuk S, Wang Y, Zhang X, Gao W, Zhao J, Cepe K, Zboril R (2015) Down-conversion monochromatic light-emitting diodes with the color determined by the active layer thickness and concentration of carbon dots. J Mater Chem C. https://doi.org/10.1039/C5TC01379H10.1039/C5TC01379H ↗
22. Zhou D, Li D, Jing P, Zhai Y, Shen D, Qu S (2017) Conquering aggregation-induced solid-state luminescence quenching of carbon dots through a carbon dots-triggered silica gelation process. Chem Mater. https://doi.org/10.1021/acs.chemmater.6b0537510.1021/acs.chemmater.6b05375 ↗
23. Liu Q, Li D, Zhu Z, Yu S, Zhang Y, Yu D (2018) N-doped carbon dots from phenol derivatives for excellent colour rendering WLEDs. RSC Adv. https://doi.org/10.1039/C7RA12522D10.1039/C7RA12522D ↗
24. Ding H, Yu SB, Wei JS (2016) Full-color light-emitting carbon dots with a surface-state-controlled luminescence mechanism. Acs Nano. https://doi.org/10.1021/acsnano.5b0540610.1021/acsnano.5b05406 ↗
25. Ge J, Jia Q, Liu W, Guo L, Liu Q, Lan M, Zhang H, Meng X. Red‐emissive carbon dots for fluorescent, photoacoustic, and thermal theranostics in living mice. Adv Mater. https://doi.org/10.1002/adma.201500323.10.1002/adma.201500323 ↗
26. Yang Y, Wang X, Liao G, Liu X, Chen Q, Li H, Lu L, Zhao P. iRGD-decorated red shift emissive carbon nanodots for tumor targeting fluorescence imaging. J Colloid Interface Sci. https://doi.org/10.1016/j.jcis.2017.09.00710.1016/j.jcis.2017.09.007 ↗
27. Xu Q, Kuang T, Liu Y, Cai L, Peng X, Sreeprasad TS, Yu Z. Heteroatom-doped carbon dots: synthesis, characterization, properties, photoluminescence mechanism and biological applications. J Mater Chem B. https://doi.org/10.1039/C6TB02131J10.1039/C6TB02131J ↗
28. Feng X, Zhang F, Wang Y, Zhang Y, Yang Y, Liu L. Luminescent carbon quantum dots with high quantum yield as a single white converter for white light emitting diodes. Appl Phys Lett. https://doi.org/10.1063/1.493623410.1063/1.4936234 ↗
29. Hu L, Sun Y,Li S, Wang X, Hu K, Wang L, Liang X (2014) Multifunctional carbon dots with high quantum yield for imaging and gene delivery. Carbon. https://doi.org/10.1016/j.carbon.2013.10.02310.1016/j.carbon.2013.10.023 ↗
30. Xu Y, Wu M, Liu Y, Feng XZ, Yin XB, He XB. Nitrogen‐doped carbon dots: a facile and general preparation method, photoluminescence investigation, and imaging applications. Chem- A Eur J. https://doi.org/10.1002/chem.20120364110.1002/chem.201203641 ↗
31. Irmania N, Dehvari K, Gedda G, Tseng PJ (2020) Manganese‐doped green tea‐derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform. J Biomed Mater Res Part B: Appl Biomater. https://doi.org/10.1002/jbm.b.3450810.1002/jbm.b.34508 ↗
32. Bourlinos AB, Trivizas G, Karakassides MA, Baikousi M, Kouloumpis A, Gournis D, Bakandritsos A, Hola K, Kozak O, Zboril R, Papagiannouli I, Aloukos P, Couris S (2015) Green and simple route toward boron doped carbon dots with significantly enhanced non-linear optical properties. Carbon. https://doi.org/10.1016/j.carbon.2014.11.03210.1016/j.carbon.2014.11.032 ↗
33. Chandra S, Patra P, Pathan SH, Roy S, Mitra S, Layek A, Bhar R , Pramanik P, Goswami B. Luminescent S-doped carbon dots: an emergent architecture for multimodal applications. J Mater Sci B. https://doi.org/10.1039/C3TB00583F10.1039/C3TB00583F ↗
34. Qian Z, Shan X, Chai L, Ma J, Chen J, Feng H (2014) Si-doped carbon quantum dots: a facile and general preparation strategy, bioimaging application, and multifunctional sensor. ACS Appl Mater Interfaces. https://doi.org/10.1021/am500403n10.1021/am500403n ↗
35. Prasad KS, Pallela R, Kim DM, Shim P (2013) Microwave‐assisted one‐pot synthesis of metal‐free nitrogen and phosphorus dual‐doped nanocarbon for electrocatalysis and cell imaging. Part PartSyst Charact. https://doi.org/10.1002/ppsc.20130002010.1002/ppsc.201300020 ↗
36. Gong Y, Yu B, Yang W, Zhang B (2016) Phosphorus, and nitrogen co-doped carbon dots as a fluorescent probe for real-time measurement of reactive oxygen and nitrogen species inside macrophages. Biosens Bioelectronics. https://doi.org/10.1016/j.bios.2016.01.02210.1016/j.bios.2016.01.022 ↗
37. Xu Q, Liu Y, Su R, Cai L, Li B, Zhang Y, Zhang L, Wang Y, Wang Y, Li N (2016) Highly fluorescent Zn-doped carbon dots as Fenton reaction-based bio-sensors: an integrative experimental–theoretical consideration. Nanoscale. https://doi.org/10.1039/C6NR05434J.10.1039/C6NR05434J ↗
38. Xu Q, Su R, Chen Y, Sreenivasan T S, Li N, Zheng X, Zhu J, Pan H, Li W, Xu C, Xia Z, Dai L. ACS Appl Nano Mater. https://doi.org/10.1021/acsanm.8b0027710.1021/acsanm.8b00277 ↗
39. Chiu SH, Gedda G, Girma WM, Chen JK, Ling YC, Ghule AV, Ou KL, Chang Y (2016) Rapid fabrication of carbon quantum dots as multifunctional nanovehicles for dual-modal targeted imaging and chemotherapy. ActaBiomater. https://doi.org/10.1016/j.actbio.2016.09.02710.1016/j.actbio.2016.09.027 ↗
40. Yao Y, Gedda G, Girma WM, Yen CL, Ling YC, Chang J (2017) Magnetofluorescent carbon dots derived from crab shell for targeted dual-modality bioimaging and drug delivery. ACS Appl Mater Interfaces. https://doi.org/10.1021/acsami.7b0159910.1021/acsami.7b01599 ↗
41. Mehta SK, Kumar S, Chaudhary S, Bhasin KK (2010) Nucleation and growth of surfactant passivated CdS and HgS nanoparticles: time-dependent absorption and luminescence profiles. Nanoscale. https://doi.org/10.1039/B9NR00070D10.1039/B9NR00070D ↗
42. Chopra N, Mansingh A, Chadha GK (1990) Electrical, optical and structural properties of amorphous V2O5 TeO2 blown films. J Non-Cryst Solids. https://doi.org/10.1016/0022-3093(90)90819-810.1016/0022-3093(90)90819-8 ↗
43. Dong Y, Wan L, Cai J, Fang Q, Chi Y, Chen G (2015) Natural carbon-based dots from humic substances. Scientific Reports. https://doi.org/10.1038/srep1003710.1038/srep10037 ↗
44. Mizuguchi M, Nara M, Kawano K, Nitta K (1997) FT-IR study of the Ca2+-binding to bovine α-lactalbumin: relationships between the type of coordination and characteristics of the bands due to the Asp COO− groups in the Ca2+-binding site. FEBS Lett. https://doi.org/10.1016/S0014-5793(97)01274-X10.1016/S0014-5793(97)01274-X ↗
45. Zheng M, Zhang H, Gong X, Xu R, Xiao Y, Dong H, Liu X,Liu Y (2013) A simple additive-free approach for the synthesis of uniform manganese monoxide nanorods with large specific surface area. Nanoscale Res Lett. https://doi.org/10.1186/1556-276X-8-16610.1186/1556-276X-8-166 ↗
46. Alaş MO, Güngör A, Genç R, Erdem E (2019) Feeling the power: robust supercapacitors from nanostructured conductive polymers fostered with Mn2+ and carbon dots. Nanoscale. https://doi.org/10.1039/C9NR03544C10.1039/C9NR03544C ↗
47. Li JY, Liu Y, Shu QW, Liang JM, Zhang F, Chen XP, Deng XY, Swihart MT, Tan KJ (2017) One-pot hydrothermal synthesis of carbon dots with efficient up- and down-converted photoluminescence for the sensitive detection of morin in a dual-readout assay. Langmuir. https://doi.org/10.1021/acs.langmuir.6b0422510.1021/acs.langmuir.6b04225 ↗
48. Yang L, Qin A, Chen S, Liao L, Qin J,Zhang K (2018) Manganese(ii) enhanced fluorescent nitrogen-doped graphene quantum dots: a facile and efficient synthesis and their applications for bioimaging and detection of Hg2+ ions. RSC Adv. https://doi.org/10.1039/C7RA12133D10.1039/C7RA12133D ↗
49. Jin X, Sun X, Chen G, Ding L, Li Y, Liu Z, Wang Z, Pan W, Hu C, Wang J, pH-sensitive carbon dots for the visualization of regulation of intracellular pH inside living pathogenic fungal cells. Carbon. https://doi.org/10.1016/j.carbon.2014.09.07110.1016/j.carbon.2014.09.071 ↗
50. Gostynski R, Conradie J Erasmus E (2017) Significance of the electron-density of molecular fragments on the properties of manganese (iii) β-diketonato complexes: an XPS and DFT study. RSC Advances. https://doi.org/10.1039/C7RA04921H.10.1039/C7RA04921H ↗
51. Ma Y, Chen Y, Liu J, Han Y, Ma S, Chen X (2018) Ratiometric fluorescent detection of chromium(VI) in real samples based on dual emissive carbon dots. Talanta. https://doi.org/10.1016/j.talanta.2018.03.08110.1016/j.talanta.2018.03.081 ↗
52. Zhang HY, Wang Y, Xiao S, Wang H, Wang JH, Feng L (2017) Rapid detection of Cr(VI) ions based on cobalt(II)-doped carbon dots. BiosensBioelectron. https://doi.org/10.1016/j.bios.2016.08.01010.1016/j.bios.2016.08.010 ↗
53. Wu W, Zhan L, Fan W, Song J, Li X , Li Z, Wang R, Zhang J, Zheng J, Wu M, Zeng H (2015) Cu-N dopants boost electron transfer and photooxidation reactions of carbon dots. AngewChem. https://doi.org/10.1002/anie.20150191210.1002/anie.201501912 ↗
54. Tadesse A, Hagos M, RamaDevi D, Basavaiah K, Belachew N (2020) Fluorescent-nitrogen-doped carbon quantum dots derived from citrus lemon juice: green synthesis, mercury(II) ion sensing, and live cell imaging. ACS Omega. https://doi.org/10.1021/acsomega.9b0317510.1021/acsomega.9b03175 ↗
55. Kayal S, Halder M (2019) A ZnS quantum dot-based super selective fluorescent chemosensor for soluble ppb-level total arsenic [As(iii) + As(v)] in aqueous media: direct assay utilizing aggregation-enhanced emission (AEE) for analytical application. Anal. https://doi.org/10.1039/C9AN00516A10.1039/C9AN00516A ↗
56. Chu HW, Unnikrishnan B, Anand A, Lin YW, Huang CC (2020) Carbon quantum dots for the detection of antibiotics and pesticides. Journal of food and drug analysis. https://doi.org/10.38212/2224-6614.126910.38212/2224-6614.1269 ↗
57. Zhao Y, Zou S, Huo D, Hou C, Yang M, Li J, Bian M (2019) Simple and sensitive fluorescence sensor for methotrexate detection based on the inner filter effect of N, S co-doped carbon quantum dots. Anal ChimActa. https://doi.org/10.1016/j.aca.2018.10.00510.1016/j.aca.2018.10.005 ↗
58. Li X, Wu X, Zhang F, Zhao B, Li Y (2019) Label-free detection of folic acid using a sensitive fluorescent probe based on ovalbumin stabilized copper nanocluster,Talanta. https://doi.org/10.1016/j.talanta.2018.11.06710.1016/j.talanta.2018.11.067 ↗
59. Chen S, Yu YL, Wang JH (2018) Inner filter effect-based fluorescent sensing systems: a review, Anal ChimActa. https://doi.org/10.1016/j.aca.2017.10.02610.1016/j.aca.2017.10.026 ↗
60. Jhonsi MA, Thulasi S, Kathiravan A. Impact of capping agent on the electron transfer dynamics of CdTe QDs with methyl viologen. J Lumin. https://doi.org/10.1016/j.jlumin.2016.06.02210.1016/j.jlumin.2016.06.022 ↗
61. An J, Gou Y, Yang C, Hu F, Wang C (2013) Synthesis of a biocompatible gelatin functionalized graphene nanosheets and its application for drug delivery. Mater SciEng: C. https://doi.org/10.1016/j.msec.2013.03.00810.1016/j.msec.2013.03.008 ↗
62. Khodadadei F, Safarian S, Ghanbari N (2017) Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system. Mater Sci Eng: C. https://doi.org/10.1016/j.msec.2017.05.04910.1016/j.msec.2017.05.049 ↗
63. Arsalani N, Mokhtari PN, Jabbari E (2019) Microwave-assisted and one-step synthesis of PEG passivated fluorescent carbon dots from gelatin as an efficient nanocarrier for methotrexate delivery. Artificial Cells, Nanomedicine, and Biotechnology. https://doi.org/10.1080/21691401.2018.156246010.1080/21691401.2018.1562460 ↗