Therapeutic potential of human breast milk derived exosomes
Source abstract
Abstract
Human breast milk as an irreplaceable source of nutrition for infants is not a new concept. Furthermore, it has also been known that human breast milk is rich in exosomes and its elements among other nutrients. With a recent explosion in research that scrutinizes the physiologic and pathologic functions of exosomes, it has brought to surface the undeniable therapeutic effects of milk-derived exosomes in treating and/or monitoring several pediatric diseases such as necrotizing enterocolitis, childhood obesity, cancer, type 1 diabetes mellitus, etc. The purpose of this review is to understand the current knowledge regarding the presence and composition of milk-derived exosomes, their functions, and potential clinical applications. The focus of this review will be on human milk–derived exosomes and its potential therapeutic effects. Studies have shown the sources and physiologic functions of exosomes are not limited and need to be well understood and isolated to further improve treatment of diseases that involve the function of exosomes. The overall literature is understanding of the effect of milk-derived exosomes on infant growth and development and is encouraging to increase the depth of knowledge of milk-derived exosomes for further therapeutic management.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Infant Nutrition and Health · COVID-19 Impact on Reproduction · Neonatal Respiratory Health Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
Show source-provided references
1. Jiang X et al (2021) Biological properties of milk-derived extracellular vesicles and their physiological functions in infant. Front Cell Dev Biol 9:69353410.3389/fcell.2021.693534 ↗
2. Kim KU, Kim WH, Jeong CH, Yi DY, Min H (2020) More than nutrition: therapeutic potential of breast milk-derived exosomes in cancer. Int J Mol Sci 21(19):732710.3390/ijms21197327 ↗
3. Feachem RG, Koblinsky MA (1984) Interventions for the control of diarrhoeal diseases among young children: promotion of breast-feeding. Bull World Health Organ 62(2):271–291
4. Furman L et al (2003) The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. Arch Pediatr Adolesc Med 157(1):66–7110.1001/archpedi.157.1.66 ↗
5. Uhari M, Mantysaari K, Niemela M (1996) A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis 22(6):1079–108310.1093/clinids/22.6.1079 ↗
6. Huang J et al (2019) Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 104(2):F128–F13610.1136/archdischild-2017-314205 ↗
7. Hill DR, Newburg DS (2015) Clinical applications of bioactive milk components. Nutr Rev 73(7):463–47610.1093/nutrit/nuv009 ↗
8. Nutrition ECO et al (2009) Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 49(1):112–2510.1097/MPG.0b013e31819f1e05 ↗
9. Ip S et al (2007) Breastfeeding and maternal and infant health outcomes in developed countries. Evid Rep Technol Assess (Full Rep) 153:1–186
10. M H Rashed et al (2017) Exosomes: from garbage bins to promising therapeutic targets. Int J Mol Sci 18(3)10.3390/ijms18030538 ↗
11. Admyre C et al (2007) Exosomes with immune modulatory features are present in human breast milk. J Immunol 179(3):1969–197810.4049/jimmunol.179.3.1969 ↗
12. Chen W et al (2020) The emerging role of exosomes in the pathogenesis, prognosis and treatment of necrotizing enterocolitis. Am J Transl Res 12(11):7020–7033
13. Hanson PI, Cashikar A (2012) Multivesicular body morphogenesis. Annu Rev Cell Dev Biol 28:337–36210.1146/annurev-cellbio-092910-154152 ↗
14. Hu Y, Thaler J and Nieuwland R (2021) Extracellular vesicles in human milk. Pharmaceuticals (Basel) 14(10)10.3390/ph14101050 ↗
15. Isola AL, Chen S (2017) Exosomes: the messengers of health and disease. Curr Neuropharmacol 15(1):157–16510.2174/1570159X14666160825160421 ↗
16. Frohlich D et al 2014 Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation. Philos Trans R Soc Lond B Biol Sci 369(1652)10.1098/rstb.2013.0510 ↗
17. Iero M et al (2008) Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ 15(1):80–8810.1038/sj.cdd.4402237 ↗
18. Yu X et al (2012) Mechanism of TNF-alpha autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1alpha, presented by exosomes. J Mol Cell Cardiol 53(6):848–85710.1016/j.yjmcc.2012.10.002 ↗
19. Mirza AH et al (2019) Breast milk-derived extracellular vesicles enriched in exosomes from mothers with type 1 diabetes contain aberrant levels of microRNAs. Front Immunol, 1010.3389/fimmu.2019.02543 ↗
20. Sánchez C et al (2021) Breast milk: a source of functional compounds with potential application in nutrition and therapy. Nutrients 13(3):102610.3390/nu13031026 ↗
21. Wang X et al (2019) Identification and peptidomic profiling of exosomes in preterm human milk: insights into necrotizing enterocolitis prevention. Mol Nutr Food Res e180124710.1002/mnfr.201801247 ↗
22. Reinhardt TA et al (2012) Bovine milk exosome proteome. J Proteomics 75(5):1486–149210.1016/j.jprot.2011.11.017 ↗
23. Chen X et al (2010) Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res 20(10):1128–113710.1038/cr.2010.80 ↗
24. Gao R et al (2019) A comparison of exosomes derived from different periods breast milk on protecting against intestinal organoid injury. Pediatr Surg Int 35(12):1363–136810.1007/s00383-019-04562-6 ↗
25. Hu Y et al (2020) Human milk triggers coagulation via tissue factor-exposing extracellular vesicles. Blood Adv 4(24):6274–628210.1182/bloodadvances.2020003012 ↗
26. Nakamura M et al (2018) Nipple skin trauma in breastfeeding women during postpartum week one. Breastfeed Med 13(7):479–48410.1089/bfm.2017.0217 ↗
27. Hock A et al (2017) Breast milk-derived exosomes promote intestinal epithelial cell growth. J Pediatr Surg 52(5):755–75910.1016/j.jpedsurg.2017.01.032 ↗
28. Frank DN et al (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104(34):13780–1378510.1073/pnas.0706625104 ↗
29. Good M et al (2015) Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol 8(5):1166–117910.1038/mi.2015.30 ↗
30. Garcia C et al (2013) Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 59(1):108–31
31. Wu RY et al (2019) Human Milk Oligosaccharides Increase Mucin Expression in Experimental Necrotizing Enterocolitis. Mol Nutr Food Res 63(3):e180065810.1002/mnfr.201800658 ↗
32. Li B et al (2019) Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis. PLoS ONE 14(1):e021143110.1371/journal.pone.0211431 ↗
33. He Y et al (2021) Milk exosomes transfer oligosaccharides into macrophages to modulate immunity and attenuate adherent-invasive e. coli (AIEC) infection. Nutrients 13(9)10.3390/nu13093198 ↗
34. Markel TA et al (2020) New directions in necrotizing enterocolitis with early-stage investigators. Pediatr Res 88(Suppl 1):35–4010.1038/s41390-020-1078-0 ↗
35. Martin RM et al (2005) Breast-feeding and childhood cancer: a systematic review with metaanalysis. Int J Cancer 117(6):1020–103110.1002/ijc.21274 ↗
36. Gungor D et al (2019) Infant milk-feeding practices and childhood leukemia: a systematic review. Am J Clin Nutr 109(Suppl_7):757S-771S10.1093/ajcn/nqy306 ↗
37. Galley JD and Besner GE (2020) The therapeutic potential of breast milk-derived extracellular vesicles. Nutrients 12(3)10.3390/nu12030745 ↗
38. Zhang B et al (2019) Adipose-derived exosomes: a novel adipokine in obesity-associated diabetes. J Cell Physiol 234(10):16692–1670210.1002/jcp.28354 ↗
39. Maligianni I et al (2021) The potential role of exosomes in child and adolescent obesity. Children (Basel) 8(3)10.3390/children8030196 ↗
40. Chang W and Wang J (2019) Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus. Cells 8(8)10.3390/cells8080853 ↗
41. Nojehdehi S et al (2018) Immunomodulatory effects of mesenchymal stem cell-derived exosomes on experimental type-1 autoimmune diabetes. J Cell Biochem 119(11):9433–944310.1002/jcb.27260 ↗
42. Malhotra D et al (2012) Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol 13(5):499–51010.1038/ni.2262 ↗
43. Jin J et al (2019) Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte. Stem Cell Res Ther 10(1):9510.1186/s13287-019-1177-1 ↗
44. Guay C et al (2019) Lymphocyte-derived exosomal microRNAs promote pancreatic beta cell death and may contribute to type 1 diabetes development. Cell Metab 29(2):348-361 e610.1016/j.cmet.2018.09.011 ↗
45. Principi N, Di Pietro GM, Esposito S (2018) Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies. J Transl Med 16(1):3610.1186/s12967-018-1417-7 ↗
46. Xi Y, Ju R, Wang Y (2022) Mesenchymal stem cell-derived extracellular vesicles for the treatment of bronchopulmonary dysplasia. Front Pediatr 10:85203410.3389/fped.2022.852034 ↗
47. Arntz OJ et al (2015) Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models. Mol Nutr Food Res 59(9):1701–171210.1002/mnfr.201500222 ↗
48. Yun B et al (2020) Short communication: dietary bovine milk-derived exosomes improve bone health in an osteoporosis-induced mouse model. J Dairy Sci 103(9):7752–776010.3168/jds.2019-17501 ↗
49. Mokarizadeh A et al (2015) Transdermal delivery of bovine milk vesicles in patients with multiple sclerosis: a novel strategy to induce MOG-specific tolerance. Med Hypotheses 85(2):141–14410.1016/j.mehy.2015.04.019 ↗