pH-responsive hyaluronic acid nanoparticles codelivering DOX and ICG for effectively chemo-photothermal combination therapy
Source abstract
Abstract
Insufficient cumulative release of chemotherapeutics at the tumor site and poor efficacy of monotherapy are the main reasons for the unsatisfactory effect of cancer therapy at present. Here, a pH-responsive nanoparticle (DAH@ICG NP) based on hyaluronic acid (HA) was designed which was loaded with the photosensitizer indocyanine green (ICG) and chemotherapeutic doxorubicin (DOX) for chemo-photothermal combination therapy against cancer. Besides, the in vitro stability, acid-sensitive release behavior, photothermal efficiency, in vitro cytotoxicity, and cell selectivity index of the DAH@ICG NPs were evaluated. Accordingly, the DAH@ICG NPs had a hydrodynamic particle size of 150.3 nm. The drug loading of DOX and ICG in the DAH@ICG5-1 NPs was 21.2% and 10.40%, respectively. What’s more, compared with human umbilical vein endothelial cells (HUVECs), in vitro cytotoxicity assay against 4T1 cells showed that the nano-delivery system showed higher cell-killing performance and the cell selectivity index (selectivity index = 9.52). More importantly, the cellular uptake of the laser-irradiated group was significantly enhanced owing to the heat generated by the photosensitizer ICG, which can improve cell membrane fluidity and destroy the extracellular matrix. Taken together, DAH@ICG NPs may be promising nanoplatforms to achieve a synergistic therapeutic effect for the combination of chemotherapy and photothermal therapy (PTT).
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Photodynamic Therapy Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Bedard PL, Hyman DM, Davids MS, Siu LL (2020) Small molecules, big impact: 20 years of targeted therapy in oncology. Lancet 395(10229):1078–1088. https://doi.org/10.1016/S0140-6736(20)30164-110.1016/S0140-6736(20)30164-1 ↗
2. Chen Q, Wang X, Wang C, Feng LZ, Li YG, Liu Z (2015) Drug-induced self-assembly of modified albumins as nano-theranostics for tumor-targeted combination therapy. ACS Nano 9(5):5223–5233. https://doi.org/10.1021/acsnano.5b0064010.1021/acsnano.5b00640 ↗
3. Chen WS, Ouyang J, Liu H, Chen M, Zeng K, Sheng JP, Liu ZJ, Han YJ, Wang LQ, Li J, Deng L, Liu YN, Guo SJ (2017) Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer. Adv Mater 29(5):7. https://doi.org/10.1002/adma.20160386410.1002/adma.201603864 ↗
4. Chen S, Sun B, Miao H, Wang G, Sun P, Li J, Wang W, Fan Q, Huang W (2020) NIR-II dye-based multifunctional telechelic glycopolymers for NIR-IIa fluorescence imaging-guided stimuli-responsive chemo-photothermal combination therapy. ACS Mater Lett 2(2):174–183. https://doi.org/10.1021/acsmaterialslett.9b0048010.1021/acsmaterialslett.9b00480 ↗
5. Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA (2010) Gold nanoparticles for biology and medicine. Angew Chem-Int Edit 49(19):3280–3294. https://doi.org/10.1002/anie.20090435910.1002/anie.200904359 ↗
6. Gu ZJ, Zhu S, Yan L, Zhao F, Zhao YL (2019) Graphene-based smart platforms for combined cancer therapy. Adv Mater 31(9):27. https://doi.org/10.1002/adma.20180066210.1002/adma.201800662 ↗
7. Guo Q, Chen J, Wang J, Zeng H, Yu J (2020) Recent progress in synthesis and application of mussel-inspired adhesives. Nanoscale 12(3):1307–1324. https://doi.org/10.1039/c9nr09780e10.1039/c9nr09780e ↗
8. Hu JJ, Cheng YJ, Zhang XZ (2018) Recent advances in nanomaterials for enhanced photothermal therapy of tumors. Nanoscale 10(48):22657–22672. https://doi.org/10.1039/c8nr07627h10.1039/c8nr07627h ↗
9. Hu Q, Huang Z, Duan Y, Fu Z, Bin L (2020) Reprogramming tumor microenvironment with photothermal therapy. Bioconjug Chem 31(5):1268–1278. https://doi.org/10.1021/acs.bioconjchem.0c0013510.1021/acs.bioconjchem.0c00135 ↗
10. Huang X, El-Sayed IH, Qian W, El-Sayed MA (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128(6):2115–2120. https://doi.org/10.1021/ja057254a10.1021/ja057254a ↗
11. Kim J, Kim J, Jeong C, Kim WJ (2016) Synergistic nanomedicine by combined gene and photothermal therapy. Adv Drug Deliv Rev 98:99–112. https://doi.org/10.1016/j.addr.2015.12.01810.1016/j.addr.2015.12.018 ↗
12. Kurmi BD, Patel P, Paliwal R, Paliwal SR (2020) Molecular approaches for targeted drug delivery towards cancer: a concise review with respect to nanotechnology. J Drug Deliv Sci Technol 57:101682. https://doi.org/10.1016/j.jddst.2020.10168210.1016/j.jddst.2020.101682 ↗
13. Lammers T, Hennink WE, Storm G (2008) Tumour-targeted nanomedicines: principles and practice. Br J Cancer 99(3):392–397. https://doi.org/10.1038/sj.bjc.660448310.1038/sj.bjc.6604483 ↗
14. Lee Y, Sugihara K, Gillilland MG III, Jon S, Kamada N, Moon JJ (2020) Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis. Nat Mater 19(1):118–126. https://doi.org/10.1038/s41563-019-0462-910.1038/s41563-019-0462-9 ↗
15. Liao J, Zheng H, Hu R, Cao J, Wei X, Li D, Zheng H, Yin Y (2018) Hyaluronan based tumor-targeting and pH-responsive shell cross-linkable nanoparticles for the controlled release of doxorubicin. J Biomed Nanotechnol 14(3):496–509. https://doi.org/10.1166/jbn.2018.251010.1166/jbn.2018.2510 ↗
16. Luo SL, Zhang EL, Su YP, Cheng TM, Shi CM (2011) A review of NIR dyes in cancer targeting and imaging. Biomaterials 32(29):7127–7138. https://doi.org/10.1016/j.biomaterials.2011.06.02410.1016/j.biomaterials.2011.06.024 ↗
17. Luo DD, Carter KA, Miranda D, Lovell JF (2017a) Chemophototherapy: an emerging treatment option for solid tumors. Adv Sci 4(1):24. https://doi.org/10.1002/advs.20160010610.1002/advs.201600106 ↗
18. Luo D, Carter KA, Miranda D, Lovell JF (2017b) Chemophototherapy: an emerging treatment option for solid tumors. Adv Sci 4(1):1600106. https://doi.org/10.1002/advs.20160010610.1002/advs.201600106 ↗
19. Makvandi P, Ali GW, Della Sala F, Abdel-Fattah WI, Borzacchiello A (2020) Hyaluronic acid/corn silk extract based injectable nanocomposite: a biomimetic antibacterial scaffold for bone tissue regeneration. Mater Sci Eng C Mater Biol Appl 107(110195). https://doi.org/10.1016/j.msec.2019.11019510.1016/j.msec.2019.110195 ↗
20. Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL (2019) Siegel RL (2019) Cancer treatment and survivorship statistics. CA Cancer J Clin 69(5):363–385. https://doi.org/10.3322/caac.2156510.3322/caac.21565 ↗
21. O’Neal DP, Hirsch LR, Halas NJ, Payne JD, West JL (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209(2):171–176. https://doi.org/10.1016/j.canlet.2004.02.00410.1016/j.canlet.2004.02.004 ↗
22. Patra D, Sengupta S, Duan WT, Zhang H, Pavlick R, Sen A (2013) Intelligent, self-powered, drug delivery systems. Nanoscale 5(4):1273–1283. https://doi.org/10.1039/c2nr32600k10.1039/c2nr32600k ↗
23. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin HS (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16:33. https://doi.org/10.1186/s12951-018-0392-810.1186/s12951-018-0392-8 ↗
24. Schaafsma BE, Mieog JSD, Hutteman M, Van der Vorst JR, Kuppen PJK, Lowik C, Frangioni JV, Van de Velde CJH, Vahrmeijer AL (2011) The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. J Surg Oncol 104(3):323–332. https://doi.org/10.1002/jso.2194310.1002/jso.21943 ↗
25. Shi JJ, Kantoff PW, Wooster R, Farokhzad OC (2017) Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer 17(1):20–37. https://doi.org/10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗
26. Spicer CD (2020) Hydrogel scaffolds for tissue engineering: the importance of polymer choice. Polym Chem 11(2):184–219. https://doi.org/10.1039/c9py01021a10.1039/c9py01021a ↗
27. Wicki A, Witzigmann D, Balasubramanian V, Huwyler J (2015) Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J Control Release 200:138–157. https://doi.org/10.1016/j.jconrel.2014.12.03010.1016/j.jconrel.2014.12.030 ↗
28. Wilhelm S, Tavares AJ, Dai Q, Ohta S, Audet J, Dvorak HF, Chan WCW (2016) Analysis of nanoparticle delivery to tumours. Nat Rev Mater 1(5):12. https://doi.org/10.1038/natrevmats.2016.1410.1038/natrevmats.2016.14 ↗
29. Xia Y, Xiao M, Zhao M, Xu T, Guo M, Wang C, Li Y, Zhu B, Liu H (2020) Doxorubicin-loaded functionalized selenium nanoparticles for enhanced antitumor efficacy in cervical carcinoma therapy. Mater Sci Eng C Mater Biol Appl 106:110100. https://doi.org/10.1016/j.msec.2019.11010010.1016/j.msec.2019.110100 ↗
30. Zhang MJ, Wang TT, Zhang LY, Li L, Wang CG (2015) Near-infrared light and pH-responsive polypyrrole@polyacrylic acid/fluorescent mesoporous silica nanoparticles for imaging and chemo-photothermal cancer therapy. Chem-Eur J 21(45):16162–16171. https://doi.org/10.1002/chem.20150217710.1002/chem.201502177 ↗
31. Zhao Z, Ukidve A, Kim J, Mitragotri S (2020) Targeting strategies for tissue-specific drug delivery. Cell 181(1):151–167. https://doi.org/10.1016/j.cell.2020.02.00110.1016/j.cell.2020.02.001 ↗