Tetrahedral DNA–mediated biomineralization of calcium carbonate nanoparticles for pH-responsive drug delivery
Source abstract
Abstract
The objective of this study is to harness the potential of biomineralization for the controlled fabrication of tetrahedral DNA (TDN)-mediated calcium carbonate (CaCO3) nanoparticles with applications in cancer therapy. While TDN has emerged as an efficient anti-cancer drug carrier, its inherent instability under physiological conditions poses challenges for sustained drug release. Biomineralization, known for its ability to maintain carrier morphology and stability in physiological environments, is leveraged in this research to enhance TDN’s drug delivery capabilities. In this study, we successfully synthesized TDN-mediated CaCO3 nanoparticles through a biomineralization process, with comprehensive characterization utilizing TEM, SEM, AFM, and DLS techniques. The morphology and crystal phase of the resulting CaCO3 nanoparticles, ranging from 10 to 100 nm, are precisely controlled by the presence of TDN. Remarkably, the engineered nanoparticles demonstrated efficient loading and controlled delivery of the anti-cancer drug doxorubicin (Dox), suggesting their potential for cancer therapy. The TDN-CaCO3 nanoparticles exhibited notable attributes including high drug loading efficiency (42.2%), favorable biocompatibility, pH responsiveness, and minimal cytotoxicity. The findings of this study underscore the potential of TDN-CaCO3 nanoparticles as a promising therapeutic agent for safe and effective cancer treatment, offering new avenues for innovative and efficient drug delivery strategies in the future. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Bacteriophages and microbial interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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