Particle Background Levels In Human Tissues—PABALIHT project. Part I: a nanometallomic study of metal-based micro- and nanoparticles in liver and kidney in an Italian population group
Source abstract
Abstract
We used field-emission scanning electron microscopy (FESEM) coupled with energy dispersive X-ray spectroscopy (EDS) microanalysis to determine size, shape, and elemental composition of particles in the liver and kidney autopsy of 35 subjects living in Sardinia. Particles were detected in 94% of livers and in 97% of kidney samples as aggregates, ranging between 50 nm and 100 μm. A total of 513 particle aggregates were observed in all tissues (276 in the liver and 237 in the kidney samples). Aggregates consisted of single elements (As, Ba, Cu, F, Fe, Ge, Hg, Ni, P, Pb, S, Si, Ti) or multiple association of elements, up to six. Silicon and Fe were the main element constituents (presence in 61% and 23% of the total Pags) followed by Al, Hg, Ni, Pb, and Ti (< 1%). Calcium, Cl, Co, Cr, Na, K, P, Sc, Sn, W, V, Zn, sometimes Mg, Rh, and Ta, were also detected. Overall, our findings suggest that the ubiquitous presence of metal species as particle aggregates in human tissues would be a condition of normality, although such presence per se is far from being used as a toxicity biomarker. Before being able to clarify the implications of particles in diseases or normal physiological processes, the biological meaning of particles background level we observed in liver and kidney must be elucidated.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Heavy Metal Exposure and Toxicity · Nanoparticles: synthesis and applications · Trace Elements in Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (67)
Show source-provided references
1. Alauddin M, Kim KK, Roy M, Song JK, Kim MS, Park SM (2013) Aggregation of laser-generated gold nanoparticles mediated by formalin. Bull Kor Chem Soc 34:188–196. https://doi.org/10.5012/bkcs.2013.34.1.18810.5012/bkcs.2013.34.1.188 ↗
2. Anderson DS, Silva RM, Lee D, Edwards PC, Sharmah A, Guo T, Pinkerton KE, van Winkle LS (2015) Persistence of silver nanoparticles in the rat lung: influence of dose, size, and chemical composition. Nanotoxicology 9:591–602. https://doi.org/10.3109/17435390.2014.95811610.3109/17435390.2014.958116 ↗
3. Apollonio M, Cossu A, Luccarini S, et al (2014) Proposta di PFVR 2013–2018 Valutazione Ambientale Strategica - RAPPORTO AMBIENTALE
4. Bahadar H, Maqbool F, Niaz K, Abdollahi M (2016) Toxicity of nanoparticles and an overview of current experimental models. Iran Biomed J 20:1–11
5. Banerjee A, Berzhkovskii A, Nossal R (2014) Efficiency of cellular uptake of nanoparticles via receptor-mediated endocytosis. Phys Biol 13:1–21. https://doi.org/10.1088/1478-3975/13/1/01600510.1088/1478-3975/13/1/016005 ↗
6. Bocca B, Sabbioni E, Mičetić I, Alimonti A, Petrucci F (2017) Size and metal composition characterization of nano- and microparticles in tattoo inks by a combination of analytical techniques. J Anal At Spectrom 32:616–628. https://doi.org/10.1039/C6JA00210B10.1039/C6JA00210B ↗
7. Bosisio S, Fortaner S, Rizzio E, Groppi F, Salvini A, Bode P, Wolterbeek B, Gioacchino M, Sabbioni E (2015) Nuclear and spectrochemical techniques in developmental metal toxicology research. Whole-body elemental composition of Xenopus laevis larvae. J Radioanal Nucl Chem 303:2127–2134. https://doi.org/10.1007/s10967-014-3792-810.1007/s10967-014-3792-8 ↗
8. Buonanno G, Fuoco FC, Stabile L (2011) Influential parameters on particle exposure of pedestrians in urban microenvironments. Atmos Environ 45:1434–1443. https://doi.org/10.1016/j.atmosenv.2010.12.01510.1016/j.atmosenv.2010.12.015 ↗
9. Buzea C, Pacheco II, Robbie K (2007) Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2:MR17–MR71. https://doi.org/10.1116/1.281569010.1116/1.2815690 ↗
10. Campagna M, Frattolillo A, Pili S, Marcias G, Angius N, Mastino C, Cocco P, Buonanno G (2016) Environmental exposure to ultrafine particles inside and nearby a military airport. Atmosphere (Basel) 7. https://doi.org/10.3390/atmos710013810.3390/atmos7100138 ↗
11. Castellini C, Ruggeri S, Mattioli S, Bernardini G, Macchioni L, Moretti E, Collodel G (2014) Long-term effects of silver nanoparticles on reproductive activity of rabbit buck. Syst Biol Reprod Med 60:143–150. https://doi.org/10.3109/19396368.2014.89116310.3109/19396368.2014.891163 ↗
12. Cesaroni G, Badaloni C, Gariazzo C, Stafoggia M, Sozzi R, Davoli M, Forastiere F (2013) Long-term exposure to urban air pollution and mortality in a cohort of more than a million adults in Rome. Environ Health Perspect 121:324–331. https://doi.org/10.1289/ehp.120586210.1289/ehp.1205862 ↗
13. Chu M, Wu Q, Yang H, Yuan R, Hou S, Yang Y, Zou Y, Xu S, Xu K, Ji A, Sheng L (2010) Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 6:670–678. https://doi.org/10.1002/smll.20090204910.1002/smll.200902049 ↗
14. De Matteis V, Valeria (2017) Exposure to inorganic nanoparticles: routes of entry, immune response, biodistribution and in vitro/in vivo toxicity evaluation. Toxics 5:29. https://doi.org/10.3390/toxics504002910.3390/toxics5040029 ↗
15. Dvorackova J, Bielnikova H, Kukutschova J, Peikertova P, Filip P, Zelenik K, Kominek P, Uvirova M, Pradna J, Cermakova Z, Dvoracek I (2015) Detection of nano- and micro-sized particles in routine biopsy material—pilot study. Biomed Pap 159:87–92. https://doi.org/10.5507/bp.2012.10410.5507/bp.2012.104 ↗
16. Dziendzikowska K, Gromadzka-Ostrowska J, Lankoff A, Oczkowski M, Krawczyńska A, Chwastowska J, Sadowska-Bratek M, Chajduk E, Wojewódzka M, Dušinská M, Kruszewski M (2012) Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats. J Appl Toxicol 32:920–928. https://doi.org/10.1002/jat.275810.1002/jat.2758 ↗
17. Ellenbecker MJ, Tsai CS-J (2015) Routes of exposure for engineered nanoparticles. In: Exposure assessment and safety considerations for working with engineered nanoparticles. John Wiley & Sons, Inc, pp 39–5010.1002/9781118998694.ch4 ↗
18. European Parliament, Council of the European Union (2008) Directive 2008/50/EC on ambient air quality and cleaner air for Europe. Off J Eur Union 152:1–44 http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2008:152:0001:0044:EN:PDF
19. FAO/WHO [Food and Agriculture Organization of the United Nations/World Health Organization] (2010) FAO/WHO expert meeting on the application of nanotechnologies in the food and agriculture sectors: potential food safety implications: Meeting Report. p 130 pp
20. Friends of the Earth U.S. (2016) Nano-particles in baby formula: Tiny new ingredients are a big concern
21. Fröhlich E, Salar-Behzadi S (2014) Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies. Int J Mol Sci 15:4795–482210.3390/ijms15034795 ↗
22. Gajdosechova Z, Lawan MM, Urgast DS, Raab A, Scheckel KG, Lombi E, Kopittke PM, Loeschner K, Larsen EH, Woods G, Brownlow A, Read FL, Feldmann J, Krupp EM (2016) In vivo formation of natural HgSe nanoparticles in the liver and brain of pilot whales. Sci Rep 6. https://doi.org/10.1038/srep3436110.1038/srep34361 ↗
23. Gatti AM (2004) Biocompatibility of micro- and nano-particles in the colon. Part II. Biomaterials 25:385–392. https://doi.org/10.1016/S0142-9612(03)00537-410.1016/S0142-9612(03)00537-4 ↗
24. Gatti AM, Bosco P, Rivasi F, Bianca S, Ettore G, Gaetti L, Montanari S, Bartoloni G, Gazzolo D (2011) Heavy metals nanoparticles in fetal kidney and liver tissues. Front Biosci (Elite Ed) 3:221–22610.2741/e236 ↗
25. Gatti AM, Montanari S, Capitani F (2013) The Quirra syndrome: matter of translational medicine. NATO Sci peace Secur Ser B Phys Biophys 55–64. https://doi.org/10.1007/978-94-007-7003-4-410.1007/978-94-007-7003-4-4 ↗
26. Gatti AM, Rivasi F (2002) Biocompatibility of micro- and nanoparticles. Part I: in liver and kidney. Biomaterials 23:2381–2387. https://doi.org/10.1016/S0142-9612(01)00374-X10.1016/S0142-9612(01)00374-X ↗
27. Gellein K, Flaten TP, Erikson KM, Aschner M, Syversen T (2008) Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res 121:221–225. https://doi.org/10.1007/s12011-007-8051-110.1007/s12011-007-8051-1 ↗
28. Gray EP, Coleman JG, Bednar AJ, Kennedy AJ, Ranville JF, Higgins CP (2013) Extraction and analysis of silver and gold nanoparticles from biological tissues using single particle inductively coupled plasma mass spectrometry. Environ Sci Technol 47:14315–14323. https://doi.org/10.1021/es403558c10.1021/es403558c ↗
29. Griffin S, Masood M, Nasim M, Sarfraz M, Ebokaiwe A, Schäfer KH, Keck C, Jacob C (2017) Natural nanoparticles: a particular matter inspired by nature. Antioxidants 7:3. https://doi.org/10.3390/antiox701000310.3390/antiox7010003 ↗
30. Halamoda-Kenzaoui B, Ceridono M, Urbán P, Bogni A, Ponti J, Gioria S, Kinsner-Ovaskainen A (2017) The agglomeration state of nanoparticles can influence the mechanism of their cellular internalisation. J Nanobiotechnology 15:48. https://doi.org/10.1186/s12951-017-0281-610.1186/s12951-017-0281-6 ↗
31. Hansen SF, Sørensen SN, Skjolding LM et al (2017) Revising REACH guidance on information requirements and chemical safety assessment for engineered nanomaterials for aquatic ecotoxicity endpoints: recommendations from the EnvNano project. Environ Sci Eur 29:1–1510.1186/s12302-017-0111-3 ↗
32. Heinzerling A, Hsu J, Yip F (2016) Respiratory health effects of ultrafine particles in children: a literature review. Water Air Soil Pollut 22710.1007/s11270-015-2726-6 ↗
33. Heringa MB, Peters RJB, Bleys RLAW, van der Lee MK, Tromp PC, van Kesteren PCE, van Eijkeren JCH, Undas AK, Oomen AG, Bouwmeester H (2018) Detection of titanium particles in human liver and spleen and possible health implications. Part Fibre Toxicol 15. https://doi.org/10.1186/s12989-018-0251-710.1186/s12989-018-0251-7 ↗
34. Iannitti T, Capone S, Gatti A et al (2010) Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy. Int J Nanomedicine 5:955–960. https://doi.org/10.2147/IJN.S1436310.2147/IJN.S14363 ↗
35. Istituto Nazionale di Statistica (ISTAT) (2017) Tavole di dati. Ambiente urbano, anno 2016. In: 14 dec 2017
36. Italian Authority for the Protection of Personal Data (2012) Autorizzazione generale al trattamento di dati personali effettuato per scopi di ricerca scientifica Gazzetta Ufficiale della Repubblica Serie Generale n. 72 del 26-3-2012, Italy
37. Katz S (2014) The chemistry and toxicology of depleted uranium. Toxics 2:50–78. https://doi.org/10.3390/toxics201005010.3390/toxics2010050 ↗
38. Khan I, Saeed K, Khan I (2017) Nanoparticles: properties, applications and toxicities. Arab J Chem
39. Kreyling WG, Semmler-Behnke M, Möller W (2006) Health implications of nanoparticles. J Nanopart Res 8:543–562. https://doi.org/10.1007/s11051-005-9068-z10.1007/s11051-005-9068-z ↗
40. Kulvietis V, Zalgeviciene V, Didziapetriene J, Rotomskis R (2011) Transport of nanoparticles through the placental barrier. Tohoku J Exp Med 225:225–234. https://doi.org/10.1620/tjem.225.22510.1620/tjem.225.225 ↗
41. Kumar M, Curtis A, Hoskins C (2018) Application of nanoparticle technologies in the combat against anti-microbial resistance. Pharmaceutics 10:11. https://doi.org/10.3390/pharmaceutics1001001110.3390/pharmaceutics10010011 ↗
42. Kwon JT, Hwang SK, Jin H, Kim DS, Minai-Tehrani A, Yoon HJ, Choi M, Yoon TJ, Han DY, Kang YW, Yoon BI, Lee JK, Cho MH (2008) Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J Occup Health 50:1–6. https://doi.org/10.1539/joh.50.110.1539/joh.50.1 ↗
43. Li YF, Gao Y, Chai Z, Chen C (2014) Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials. Metallomics, In
44. Liao J, Zhang Y, Yu W, Xu L, Ge C, Liu J, Gu N (2003) Linear aggregation of gold nanoparticles in ethanol. Colloids Surfaces A Physicochem Eng Asp 223:177–183. https://doi.org/10.1016/S0927-7757(03)00156-010.1016/S0927-7757(03)00156-0 ↗
45. Liu J, Wang Z, Liu FD, Kane AB, Hurt RH (2012) Chemical transformations of nanosilver in biological environments. ACS Nano 6:9887–9899. https://doi.org/10.1021/nn303449n10.1021/nn303449n ↗
46. Nguyen HL, Nguyen HN, Nguyen HH, Luu MQ, Nguyen MH (2014) Nanoparticles: synthesis and applications in life science and environmental technology. Adv Nat Sci Nanosci Nanotechnol 6:015008. https://doi.org/10.1088/2043-6262/6/1/01500810.1088/2043-6262/6/1/015008 ↗
47. Noronha Oliveira M, Schunemann WVH, Mathew MT, Henriques B, Magini RS, Teughels W, Souza JCM (2018) Can degradation products released from dental implants affect peri-implant tissues? J Periodontal Res 53:1–1110.1111/jre.12479 ↗
48. Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–83910.1289/ehp.7339 ↗
49. Oh N, Park JH (2014) Endocytosis and exocytosis of nanoparticles in mammalian cells. Int J Nanomedicine 9:51–63
50. Pedata P, Garzillo EM, Sannolo N (2010) Ultrafine particles and effects on the body: review of the literature. G Ital Med Lav Erg 32:23–31
51. Pietroiusti A (2012) Health implications of engineered nanomaterials. Nanoscale 4:1231. https://doi.org/10.1039/c2nr11688j10.1039/c2nr11688j ↗
52. Pulit-Prociak J, Banach M (2016) Silver nanoparticles—a material of the future.? Open Chem 14:76–91. https://doi.org/10.1515/chem-2016-000510.1515/chem-2016-0005 ↗
53. Ramachandran G (2011) Assessing nanoparticle risks to human health10.1016/B978-1-4377-7863-2.00012-1 ↗
54. Rappoport J, Preece J, Chipman K (2011) How do manufactured nanoparticles enter cells? UK Mathematics-in-Medicine Study Group Reading, In
55. Roncati L, Gatti AM, Pusiol T, Barbolini G, Maiorana A, Montanari S (2015) ESEM detection of foreign metallic particles inside ameloblastomatous cells. Ultrastruct Pathol 39:329–335. https://doi.org/10.3109/01913123.2015.104260810.3109/01913123.2015.1042608 ↗
56. Scott-Fordsmand JJ, Peijnenburg W, Semenzin E, Nowack B, Hunt N, Hristozov D, Marcomini A, Irfan MA, Jiménez AS, Landsiedel R, Tran L, Oomen A, Bos P, Hund-Rinke K (2017) Environmental risk assessment strategy for nanomaterials. Int J Environ Res Public Health 14:1251. https://doi.org/10.3390/ijerph1410125110.3390/ijerph14101251 ↗
57. Shin S, Song I, Um S (2015) Role of physicochemical properties in nanoparticle toxicity. Nanomaterials 5:1351–1365. https://doi.org/10.3390/nano503135110.3390/nano5031351 ↗
58. Urban RM, Jacobs JJ, Tomlinson MJ et al (2000) Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg Am 82:457–47610.2106/00004623-200004000-00002 ↗
59. Viana M, Fonseca AS, Querol X, López-Lilao A, Carpio P, Salmatonidis A, Monfort E (2017) Workplace exposure and release of ultrafine particles during atmospheric plasma spraying in the ceramic industry. Sci Total Environ 599–600:2065–2073. https://doi.org/10.1016/j.scitotenv.2017.05.13210.1016/j.scitotenv.2017.05.132 ↗
60. Wichmann HE, Spix C, Tuch T, et al (2000) Daily mortality and fine and ultrafine particles in Erfurt, Germany part I: role of particle number and particle mass. Res Rep Heal Eff Inst 5–94
61. Wong TY, Wu CY, Martel J, Lin CW, Hsu FY, Ojcius DM, Lin PY, Young JD (2015) Detection and characterization of mineralo-organic nanoparticles in human kidneys. Sci Rep 5. https://doi.org/10.1038/srep1527210.1038/srep15272 ↗
62. World Medical Association (2013) World medical association declaration of Helsinki. Ethical principles for medical research involving human subjects. J Am Med Assoc 310:2191–2194. https://doi.org/10.1001/jama.2013.28105310.1001/jama.2013.281053 ↗
63. Wu CY, Young L, Young D, Martel J, Young JD (2013) Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids. PLoS One 8:e75501. https://doi.org/10.1371/journal.pone.007550110.1371/journal.pone.0075501 ↗
64. Xia Z, Ricciardi BF, Liu Z, von Ruhland C, Ward M, Lord A, Hughes L, Goldring SR, Purdue E, Murray D, Perino G (2017) Nano-analyses of wear particles from metal-on-metal and non-metal-on-metal dual modular neck hip arthroplasty. Nanomedicine Nanotechnology, Biol Med 13:1205–1217. https://doi.org/10.1016/j.nano.2016.11.00310.1016/j.nano.2016.11.003 ↗
65. Yang L, Kuang H, Zhang W, Aguilar ZP, Wei H, Xu H (2017) Comparisons of the biodistribution and toxicological examinations after repeated intravenous administration of silver and gold nanoparticles in mice. Sci Rep 7:3303. https://doi.org/10.1038/s41598-017-03015-110.1038/s41598-017-03015-1 ↗
66. Zhou Y, Peng Z, Seven ES, Leblanc RM (2018) Crossing the blood-brain barrier with nanoparticles. J Control Release 270:290–30310.1016/j.jconrel.2017.12.015 ↗
67. Zoroddu MA, Medici S, Ledda A, Nurchi V, Lachowicz J, Peana M (2014) Toxicity of nanoparticles. Curr Med Chem 21:3837–385310.2174/0929867321666140601162314 ↗