Preparation and characterization of hollow magnetic composite nanoparticles for cisplatin delivery
Source abstract
Abstract
Magnetic polymer microsphere is a kind of hybrid microsphere composed of polymer and inorganic magnetic particles. The materials have potential applications in biomedicine, catalysis, sewage treatment, etc. The objective of this paper was to develop a targeted anticancer drug delivery system based on carboxymethyl chitosan-coated Fe3O4/SiO2 hollow microspheres (HMS-CMCS) combining receptor-mediated targeting and magnetic targeting. The binding of chitosan to the surface of modified Fe3O4/SiO2 hollow microspheres could effectively prevent them from fusing with one another and undesirable payload release in regular storage or physiological environments. The synthesized HMS-CMCS microspheres could completely release the CDDP which was used as a model drug. The obtained HMS-CMCS had the hollow structure, and the walls of the HMS-CMCS had numerous micropores with a broad distribution of approximately 1 nm. The composite particles were characterized by TEM, FT-IR, and VSM. The results showed that the microspheres had an average size of 400 nm. The fabricated material is thus proposed as a biological material for drug delivery.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanomaterials for catalytic reactions · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. Assaada E, Wang YJ, Zhu XX, Mateescu MA (2011) Polyelectrolyte complex of carb-oxymethyl starch and chitosan as drug carrier for oral administration. Carbohydr Polym 84:1399–140710.1016/j.carbpol.2011.01.048 ↗
2. Badreldin H, Mansour S, Moundhri A (2006) Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol 44:1173–118310.1016/j.fct.2006.01.013 ↗
3. Berg JH, Beijnen JH, Balm JM, Schellens JHM (2006) Future opportunities in preventing cisplat in induced ototoxicity. Cancer Treat Rev 32:390–39710.1016/j.ctrv.2006.04.011 ↗
4. Blanka R (2007) Biocompatibility and immunocompatibility of water-soluble polymers based on HPMA. Compos Part B 38:386–39710.1016/j.compositesb.2006.07.007 ↗
5. Bumbu GG, Munteanu BS, Eckelt J, Vasile C (2009) Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release. Express Polym Lett 3:286–29410.3144/expresspolymlett.2009.36 ↗
6. Chupin V, Kroon A, Kruijff B (2004) Molecular architecture of nanocapsules, bilayer-enclosed solid particles of cisplatin. J Am Chem Soc 126:13816–1382110.1021/ja0468933 ↗
7. Deng HJ, Lei ZL (2013) Preparation and characterization of hollow Fe3O4/SiO2@PEG–PLA nanoparticles for drug delivery. Compos Part B 54:194–19910.1016/j.compositesb.2013.05.010 ↗
8. Deng YH, Wang CC, Shen XZ, Yang WL, Lan J, Hong G, Fu SK (2005) Preparation, characterization, and application of multistimuli-responsive microspheres with fluorescence-labeled magnetic cores and thermoresponsive shells. Chemistry 20:6006–601310.1002/chem.200500605 ↗
9. Deng KL, Tian H, Zhang PF, Ren XB, Zhong HB (2009) Synthesis and characterization of a novel temperature-pH responsive copolymer of 2-hydroxypropyl acrylate and aminoethyl methacrylate hydrochloric salt. Express Polym Lett 3:97–10410.3144/expresspolymlett.2009.13 ↗
10. Deng YH, Cai Y, Sun ZK, Liu J, Liu C, Wei J, Li W, Wang Y, Zhao DY (2010) Multifunctional mesoporous composite microspheres with well-designed nanostructure: a highly integrated catalyst system. J Am Chem Soc 132(24):8466–847310.1021/ja1025744 ↗
11. Deng YH, Cai Y, Sun ZK, Zhao DY (2011) Magnetically responsive ordered mesoporous materials: a burgeoning family of functional composite nanomaterials. Chem Phys Lett 510(1–3):1–1310.1016/j.cplett.2011.04.093 ↗
12. Dutkiewicz JK (2002) Superabsorbent materials from shellfish waste: a review. Inc J Biomed Mater Res 63:373–38110.1002/jbm.10231 ↗
13. Ghorbani M, Eisazadeh H (2013) Removal of COD, color, anions and heavy metals from cotton textile wastewater by using polyaniline and polypyrrole nanocomposites coated on rice husk ash. Compos B 45:1–710.1016/j.compositesb.2012.09.035 ↗
14. Hu R, Chen YY, Zhang LM (2010) Synthesis and characterization of in situ photogelable polysaccharide derivative for drug delivery. Int J Pharm 393:96–103
15. Huang SL (2008) Liposomes in ultrasonic drug and gene delivery. Adv Drug Deliver Rev 60:1167–117610.1016/j.addr.2008.03.003 ↗
16. Kedar U, Phutane P, Shidhaye S, Kadam V (2010) Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine 6:714–72910.1016/j.nano.2010.05.005 ↗
17. Kobayashi H, Miyanaga E, Okubo M (2007) Preparation of multihollow polymer particles by seeded emulsion polymerization using seed particles with incorporated nonionic emulsifier. Langmuir 23:8703–870810.1021/la7010748 ↗
18. Lechevallier S, Hammer P, Jose MA, Mazeres S, Mauricot R, Verelst M, Dexpert H, Sidney JL, Jeannette DG (2012) APTES-modified RE2O3:Eu3+ luminescent beads: structure and properties. Langmuir 28:3962–397110.1021/la204469f ↗
19. Liu TY, Chen SY, Lin YL, Liu DM (2006) Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation. Langmuir 22:9705–9740
20. Liu J, Deng YH, Liu C, Sun ZK, Zhao DY (2009) A simple approach to the synthesis of hollow microspheres with magnetite/silica hybrid walls. J Colloid Interface Sci 333:329–33410.1016/j.jcis.2009.02.013 ↗
21. Phromsopha T, Baimark Y (2010) Chitosan microparticles prepared by the water-in-oil emulsion solvent diffusion method for drug delivery. Biotechnology 9:61–6610.3923/biotech.2010.61.66 ↗
22. Prabaharan M, Gong SQ (2008) Novel thiolated carboxymethyl chitosan-g-b-cyclodextrin as mucoadhesive hydrophobic drug delivery carriers. Carbohydr Polym 73:117–12510.1016/j.carbpol.2007.11.005 ↗
23. Ramachandran S, Quist AP, Kumar S, Lal R (2006) Cisplatin nanoliposomes for cancer therapy: AFM and fluorescence imaging of cisplatin encapsulation, stability, cellular uptake, and toxicity. Langmuir 22:8156–816210.1021/la0607499 ↗
24. Shen JM, Tang WJ, Zhang XL, Chen T, Zhang HX (2012) A novel carboxymethyl chitosan-based folate/Fe3O4/CdTe nanoparticle for targeted drug delivery and cell imaging. Carbohydr Polym 88:239–24910.1016/j.carbpol.2011.11.087 ↗
25. Tan YL, Han F, Ma S, Yu WG (2011) Carboxymethyl chitosan prevents formation of broad spectrum biofilm. Carbohydr Polym 84:1365–137010.1016/j.carbpol.2011.01.036 ↗
26. Xia X, Dong XJ, Wei QF, Cai YB, Lu KY (2012) Formation mechanism of porous hollow SnO2 nanofibers prepared by one-step electrospinning. Express Polym Lett 6:169–17610.3144/expresspolymlett.2012.18 ↗
27. Xiong QQ, Tu JP, Lu Y, Chen J, Yu YX, Qiao YQ, Wang XL, Gu CD (2012) Synthesis of hierarchical hollow-structured single-crystalline magnetite (Fe3O4) microspheres: the highly powerful storage versus lithium as an anode for lithium ion batteries. J Phys Chem C 116:6495–650210.1021/jp3002178 ↗
28. Xu P, Edward A, Kirk V, William JM, Zhan YH, Dale DI, Radosz M, Shen YQ (2006a) Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules 7:829–83510.1021/bm050902y ↗
29. Xu H, Cui LL, Tong NH, Gu HC (2006b) Development of high magnetization Fe3O4/polystyrene/silica nanospheres via combined miniemulsion/emulsion polymerization. J Am Chem Soc 128:15582–1558310.1021/ja066165a ↗
30. Xue XT, Li L, He JX (2009) The performances of carboxymethyl chitosan in wash-off reactive dyeing. Carbohydr Polym 75:203–20710.1016/j.carbpol.2008.05.012 ↗
31. Yan XL, Gemeinhart RA (2005) Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles. J Control Release 106:198–20810.1016/j.jconrel.2005.05.005 ↗
32. Yan SF, Yin JB, Yu Y, Luo K, Chen XS (2009) Thermo and pH-sensitive poly (vinylmethylether)/carboxymethylchitosan hydrogels crosslinked using electron beamirradiation or using glutaraldehyde as a crosslinker. Polym Int 58:1246–125110.1002/pi.2649 ↗
33. Yokoyama M (2011) Clinical applications of polymeric micelle carrier systems in chemotherapy and image diagnosis of solid tumors. J Exp Clin Med 3:151–15810.1016/j.jecm.2011.06.002 ↗
34. Zhang YW, Jiang M, Zhao JX, Wang ZX, Dou HJ, Chen DY (2005) pH-responsive core shell particles and hollow spheres attained by macromolecular self-assembly. Langmuir 21:1531–153810.1021/la047912p ↗
35. Zhou J, Wu W, Caruntu D, Yu MH, Martin A, Chen JF, O’Connor CJ, Zhou WL (2007) Synthesis of porous magnetic hollow silica nanospheres for nanomedicine application. J Phys Chem C 111:17473–1747710.1021/jp074123i ↗