Surface modification of cadmium-based nanoparticles with d-penicillamine—study of pH influence on ligand exchange reaction
Source abstract
Abstract
Abstract Semiconducting nanoparticles (NPs) find applications in many fields, with a recent focus on medicine and biology. Functionalization of the surface of NPs is necessary, and one of the most commonly employed techniques is ligand exchange (LE). In this paper, the study of pH influence on LE reaction for different types of cadmium-based NPs (quantum dots, nanorods, and nanoplates) is presented. Hydrophobic NPs were transferred to the non-organic medium by functionalization with d-penicillamine (DPA). The LE procedure was conducted at four different pH levels (4, 7, 9, and 11), and obtained hydrophilic NPs were dispersed in phosphate buffer. Results show that the most effective procedure resulted from a reaction carried at pH = 4; however, NPs with higher photoluminescence intensity were obtained when pH = 11 was used. Comparable emission was achieved from samples at pH = 4 and pH = 9. The least effective transfer, resulting in unstable NPs, occurred when the procedure was conducted at pH = 7.
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Research context
OpenAlex topics: Quantum Dots Synthesis And Properties · Advanced biosensing and bioanalysis techniques · Nanocluster Synthesis and Applications
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References (38)
Show source-provided references
1. Adel P, Bloh J, Hinrichs D, Kodanek T, Dorfs D (2017) Determination of all dimensions of CdSe seeded CdS nanorods solely via their UV/Vis spectra. Z Phys Chem 231(1):93–106. https://doi.org/10.1515/zpch-2016-088710.1515/zpch-2016-0887 ↗
2. Aldana J, Lavelle N, Wang Y, Peng X (2005) Size-dependent dissociation pH of thiolate ligands from cadmium chalcogenide nanocrystals. J Am Chem Soc 127:2496–2504. https://doi.org/10.1021/ja047000+10.1021/ja047000+ ↗
3. Al-Majed A, Belal F, Julkhuf S, El-Subbagh H (2005) Penicillamine: physical profile. In: Brittain HG (ed) Profiles of drug substances, excipients and related methodology, Vol 32. Elsevier, San Diego, pp 119–13010.1016/S0099-5428(05)32004-1 ↗
4. Blanco-Canosa JB, Wu M, Susumu K, Petryayeva E, Jennings TL, Dawson PE, Algar WR, Medintz IL (2014) Recent progress in the bioconjugation of quantum dots. Coordin Chem Rev 263–264:101–137. https://doi.org/10.1016/j.ccr.2013.08.03010.1016/j.ccr.2013.08.030 ↗
5. Breus VV, Heyes CD, Tron K, Nienhaus GU (2009) Zwitterionic biocompatible quantum dots for wide pH stability and weak nonspecific binding to cells. ACS Nano 3(9):2573–2580. https://doi.org/10.1021/nn900600w10.1021/nn900600w ↗
6. Čapek RK, Moreels I, Lambert K, De Muynck D, Zhao Q, Van Tomme A, Vanhaecke F, Hens Z (2010) Optical properties of zincblende cadmium selenide quantum dots. J Phys Chem C 114:6371–6376. https://doi.org/10.1021/jp100198910.1021/jp1001989 ↗
7. Carbone L, Nobile C, De Giorgi M, Sala FD, Morello G, Pompa P, Hytch M, Snoeck E, Fiore A, Franchini IR, Nadasan M, Silvestre AF, Chiodo L, Kudera S, Cingolani R, Krahne R, Manna L (2007) Synthesis and micrometer-scale assembly of colloidal CdSe/CdS nanorods prepared by a seeded growth approach. Nano Lett 7(10):2942–2950. https://doi.org/10.1021/nl071766110.1021/nl0717661 ↗
8. Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wie H, Han H-S, Fukumura D, Jain RK, Bawendi MG (2013) Compact high-quality CdSe–CdS core–shell nanocrystals with narrow emission linewidths and suppressed blinking. Nat Mater 12:445–451. https://doi.org/10.1038/nmat353910.1038/nmat3539 ↗
9. El Ibrahimi B, Jmiai A, Somoue A, Oukhrib R, Chadili M, El Issami S, Bazzi L (2018) Cysteine duality effect on the corrosion inhibition and acceleration of 3003 aluminium alloy in a 2% NaCl solution. Port Electrochim Acta 36(6):403–422. https://doi.org/10.4152/pea.20180640310.4152/pea.201806403 ↗
10. El-Bially AB, Seoudi R, Eisa W, Shabaka AA, Soliman SI, Abd El-Hamid RK, Ramadan RA (2012) Preparation, characterization and physical properties of CdS nanoparticles with different sizes. J Appl Sci Res 8(2):676–685
11. Howard-Lock HE, Lock CJL, Martins ML (1991) Amino acid/zwitterion equilibria 11: vibrational and NMR studies of substituted thiazolidine-4-carboxylic acids. Can J Chem 69:1721–1727. https://doi.org/10.1139/v91-25210.1139/v91-252 ↗
12. Hu L, Zhang C, Zeng G, Chen G, Wan J, Guo Z, Wu H, Yu Z, Zhou Y, Liu J (2016) Metal-based quantum dots: synthesis, surface modification, transport and fate in aquatic environments and toxicity to microorganisms. RSC Adv 6:78595–78610. https://doi.org/10.1039/C6RA13016J10.1039/C6RA13016J ↗
13. Ithurria S, Tessier MD, Mahler B, Lobo RPSM, Dubertret B, Efros AL (2011) Colloidal nanoplatelets with two-dimensional electronic structure. Nat Mater 10(12):936–941. https://doi.org/10.1038/nmat314510.1038/nmat3145 ↗
14. Jamieson T, Bakhshi R, Petrova D, Pocock R, Imani M, Seifalian AM (2007) Biological applications of quantum dots. Biomaterials 28:4717–4732. https://doi.org/10.1016/j.biomaterials.2007.07.01410.1016/j.biomaterials.2007.07.014 ↗
15. Karakoti AS, Shukla R, Shanker R, Singh S (2015) Surface functionalization of quantum dots for biological applications. Adv Colloid Interfac 215:28–45. https://doi.org/10.1016/j.cis.2014.11.00410.1016/j.cis.2014.11.004 ↗
16. Klostranec JM, Chan WCW (2006) Quantum dots in biological and biomedical research: recent progress and present challenges. Adv Mater 18:1953–1964. https://doi.org/10.1002/adma.20050078610.1002/adma.200500786 ↗
17. Kormilina TK, Cherevkov SA, Fedorov AV, Baranov AV (2017) Cadmium chalcogenide nano-heteroplatelets: creating advanced nanostructured materials by shell growth, substitution, and attachment. Small 13(41):1702300. https://doi.org/10.1002/smll.20170230010.1002/smll.201702300 ↗
18. La Rosa M, Avellini T, Lincheneau C, Silvi S, Wright IA, Constable EC, Credi A (2017) An efficient method for the surface functionalization of luminescent quantum dots with lipoic acid based ligands. Eur J Inorg Chem 2017(44):5143–5151. https://doi.org/10.1002/ejic.20170078110.1002/ejic.201700781 ↗
19. Lee CM, Jang DR, Cheong SJ, Kim EM, Jeong MH, Kim SH, Kim DW, Lim ST, Sohn MH, Jeong HJ (2010) Surface engineering of quantum dots for in vivo imaging. Nanotechnology 21(28):285102. https://doi.org/10.1088/0957-4484/21/28/28510210.1088/0957-4484/21/28/285102 ↗
20. Lesiak A, Drzozga K, Cabaj J, Bański M, Malecha K, Podhorodecki A (2019) Optical sensors based on II-VI quantum dots. Nanomaterials 9(2):192. https://doi.org/10.3390/nano902019210.3390/nano9020192 ↗
21. Lim SJ, Ma L, Schleife A, Smith AM (2016) Quantum dot surface engineering: toward inert fluorophores with compact size and bright, stable emission. Coordin Chem Rev 320-321:216–237. https://doi.org/10.1016/j.ccr.2016.03.01210.1016/j.ccr.2016.03.012 ↗
22. Liu X, Luo Y (2014) Surface modifications technology of quantum dots based biosensors and their medical applications. Chin J Anal Chem 42(7):1061–1069. https://doi.org/10.1016/S1872-2040(14)60753-210.1016/S1872-2040(14)60753-2 ↗
23. Matea CT, Mocan T, Tabaran F, Pop T, Mosteanu O, Puia C, Iancu C, Mocan L (2017) Quantum dots in imaging, drug delivery and sensor applications. Int J Nanomedicine 12:5421–5431. https://doi.org/10.2147/IJN.S13862410.2147/IJN.S138624 ↗
24. Mohammad-Rezaei R, Razmi H, Abdolmohammad-Zadeh H (2013) d-penicillamine capped cadmium telluride quantum dots as a novel fluorometric sensor of copper(II). Luminescence 28(4):503–509. https://doi.org/10.1002/bio.248410.1002/bio.2484 ↗
25. Pong B-K, Trout BL, Lee J-Y (2008) Modified ligand-exchange for efficient solubilization of CdSe/ZnS quantum dots in water: a procedure guided by computational studies. Langmuir 24:5270–5276. https://doi.org/10.1021/la703431j10.1021/la703431j ↗
26. Shen Y, Gee MY, Tan R, Pellechia PJ, Greytak AB (2013) Purification of quantum dots by gel permeation chromatography and the effect of excess ligands on Shell growth and ligand exchange. Chem Mater 25(14):2838–2848. https://doi.org/10.1021/cm401273410.1021/cm4012734 ↗
27. Smith AM, Nie S (2010) Semiconductor nanocrystals: structure, properties, and band gap engineering. Acc Chem Res 43(2):190–200. https://doi.org/10.1021/ar900106910.1021/ar9001069 ↗
28. Smith AM, Duan H, Rhyner MN, Ruan G, Nie S (2006) A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Phys Chem Chem Phys 8:3895–3903. https://doi.org/10.1039/B606572B10.1039/B606572B ↗
29. Spanhel L, Haase M, Weller H, Henglein A (1987) Photochemistry of colloidal semiconductors. 20. Surface modification and stability of strong luminescing CdS particles. J Am Chem Soc 109(19):5649–5655. https://doi.org/10.1021/ja00253a01510.1021/ja00253a015 ↗
30. Tessier MD, Spinicelli P, Dupont D, Patriarche G, Ithurria S, Dubertret B (2013) Efficient exciton concentrators built from colloidal Core/crown CdSe/CdS semiconductor nanoplatelets. Nano Lett 14(1):207–213. https://doi.org/10.1021/nl403746p10.1021/nl403746p ↗
31. Thovhogi N, Sibuyi NRS, Onani MO, Meyer M, Madiehe AM (2018) Peptide-functionalized quantum dots for potential applications in the imaging and treatment of obesity. Int J Nanomedicine 13:2551–2559. https://doi.org/10.2147/IJN.S15868710.2147/IJN.S158687 ↗
32. Vasudevan D, Gaddam RR, Trinchi A, Cole I (2015) Core–shell quantum dots: properties and applications. J Alloy Compd 636:395–404. https://doi.org/10.1016/j.jallcom.2015.02.10210.1016/j.jallcom.2015.02.102 ↗
33. Wang J, Han S, Ke D, Wang R (2012) Semiconductor quantum dots surface modification for potential cancer diagnostic and therapeutic applications. J Nanomater 2012:129041–129048. https://doi.org/10.1155/2012/12904110.1155/2012/129041 ↗
34. Wang S, Zhou C, Yuan H, Shen H, Zhao W, Ma L, Li LS (2013) A robust ligand exchange approach for preparing hydrophilic, biocompatible photoluminescent quantum dots. Mater Res Bull 48:2836–2842. https://doi.org/10.1016/j.materresbull.2013.04.01510.1016/j.materresbull.2013.04.015 ↗
35. Wenger WN, Bates FS, Aydil ES (2017) Functionalization of cadmium selenide quantum dots with poly(ethylene glycol): ligand exchange, surface coverage, and dispersion stability. Langmuir 33:8239–8245. https://doi.org/10.1021/acs.langmuir.7b0192410.1021/acs.langmuir.7b01924 ↗
36. Wilson EW, Martin RB (1971) Penicillamine deprotonations and interactions with copper ions. Arch Biochem Biophys 142(2):445–454. https://doi.org/10.1016/0003-9861(71)90508-x10.1016/0003-9861(71)90508-x ↗
37. Zahin N, Anwar R, Tewari D, Kabir T, Sajid A, Mathew B, Uddin S, Aleya L, Abdel-Daim M (2019) Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery. Environ Sci Pollut Res 27:19151–19168. https://doi.org/10.1007/s11356-019-05211-010.1007/s11356-019-05211-0 ↗
38. Zhou J, Liu Y, Tang J, Tang W (2017) Surface ligands engineering of semiconductor quantum dots for chemosensory and biological application. Mater Today 20(7):360–376. https://doi.org/10.1016/j.mattod.2017.02.00610.1016/j.mattod.2017.02.006 ↗