Synthesis of magnetic thermosensitive microcontainers for enzyme immobilization
Source abstract
Abstract
We present a new approach for the fabrication of magnetic thermoresponsive polymer microcapsules with mobile magnetic spherical cores. The microcontainers form fried-egg-like structures with a polymer shell layer of 50 nm due to the existence of hollow cavities. The microcontainers undergo a temperature-induced volume phase transition upon changing the temperature and present an impressive magnetic response. The magnetic saturation of these smart microcontainers (42 emu/g) is high enough to meet most requirements of bioapplications. To further investigate the potential application of these smart microcontainers in biotechnology, Candida rugosa lipase was selected for the enzyme immobilization process. The immobilized lipase exhibited excellent thermal stability and reusability in comparison with the free enzyme. The adsorption/release of the lipase from the microcontainers can be controlled by the environmental temperature and magnetic force, thus, offering new potential applications such as in controlled drug delivery, bioseparation, and catalysis.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Microfluidic and Capillary Electrophoresis Applications · Innovative Microfluidic and Catalytic Techniques Innovation · Enzyme Catalysis and Immobilization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (37)
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