Synthesis and characterization of superparamagnetic nanoparticles coated with fluorescent gold nanoclusters
Source abstract
Abstract
Multifunctional nanoparticles (NPs) combining the superparamagnetism of Mn−Zn ferrite and the fluorescence property of gold nanoclusters (NCs) have been prepared by wet chemistry. Magnetic NPs synthesized by co-precipitation method were coated several times with oppositely charged polyelectrolytes (PEs) using the layer-by-layer technique. Common techniques (Fourier transform infrared spectroscopy, electron microscopy, zeta potential, etc.) indicated the monodispersity and the stability of the coated NPs providing a positive charged surface. Fluorescent gold NCs bound to a standard protein bovine serum albumin were adsorbed on the surface of the magnetic NPs. Structural investigations proved the presence of small gold clusters (~2 nm) in a shell surrounding the magnetic nanomaterial. The stable nanocomposite kept the original fluorescence property of the metal clusters with 211-fold increase of the red emission (λ = 690 nm) compared to the uncoated NPs. These NPs can be moved with a permanent magnet despite a 72-wt% increase of the non-magnetic fraction due to the PE coating and the protein adsorption.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanocluster Synthesis and Applications · Gold and Silver Nanoparticles Synthesis and Applications · Protein Interaction Studies and Fluorescence Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
Show source-provided references
1. Alexiou C, Jurgons R, Seliger G, Iro H (2006) Medical applications of magnetic nanoparticles. J Nanosci Nanotechnol 6(9–10):2762–2768. doi: 10.1166/Jnn.2006.46410.1166/jnn.2006.464 ↗
2. Auzans E, Zins D, Blums E, Massart R (1999) Synthesis and properties of Mn–Zn ferrite ferrofluids. J Mater Sci 34(6):1253–126010.1023/A:1004525410324 ↗
3. Bao YP, Zhong C, Vu DM, Temirov JP, Dyer RB, Martinez JS (2007) Nanoparticle-free synthesis of fluorescent gold nanoclusters at physiological temperature. J Phys Chem C 111(33):12194–12198. doi: 10.1021/Jp071727d10.1021/jp071727d ↗
4. Bawendi MG, Carroll PJ, Wilson WL, Brus LE (1992) Luminescence properties of Cdse quantum crystallites—resonance between interior and surface localized states. J Chem Phys 96(2):946–95410.1063/1.462114 ↗
5. Beji Z, Hanini A, Smiri LS, Gavard J, Kacem K, Villain F, Greneche JM, Chau F, Ammar S (2010) Magnetic properties of Zn-substituted MnFe2O4 nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells. Chem Mater 22(19):5420–5429. doi: 10.1021/Cm100170810.1021/cm1001708 ↗
6. Bridot JL, Faure AC, Laurent S, Riviere C, Billotey C, Hiba B, Janier M, Josserand V, Coll JL, Vander Elst L, Muller R, Roux S, Perriat P, Tillement O (2007) Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging. J Am Chem Soc 129(16):5076–5084. doi: 10.1021/Ja068356j10.1021/ja068356j ↗
7. Chantrell RW, Popplewell J, Charles SW (1978) Measurements of particle-size distribution parameters in ferrofluids. IEEE Trans Magn 14(5):975–97710.1109/TMAG.1978.1059918 ↗
8. Corr SA, Rakovich YP, Gun’ko YK (2008) Multifunctional magnetic-fluorescent nanocomposites for biomedical applications. Nanoscale Res Lett 3(3):87–104. doi: 10.1007/S11671-008-9122-810.1007/s11671-008-9122-8 ↗
9. Duan HW, Nie SM (2007) Etching colloidal gold nanocrystals with hyperbranched and multivalent polymers: a new route to fluorescent and water-soluble atomic clusters. J Am Chem Soc 129(9):2412. doi: 10.1021/Ja067727t10.1021/ja067727t ↗
10. Gao CY, Leporatti S, Moya S, Donath E, Mohwald H (2003) Swelling and shrinking of polyelectrolyte microcapsules in response to changes in temperature and ionic strength. Chem Eur J 9(4):915–92010.1002/chem.200390113 ↗
11. Harris JJ, Bruening ML (2000) Electrochemical and in situ ellipsometric investigation of the permeability and stability of layered polyelectrolyte films. Langmuir 16(4):2006–201310.1021/la990620h ↗
12. Jain PK, Huang XH, El-Sayed IH, El-Sayed MA (2008) Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. Acc Chem Res 41(12):1578–1586. doi: 10.1021/Ar700280410.1021/ar7002804 ↗
13. Kim J, Lee JE, Lee J, Yu JH, Kim BC, An K, Hwang Y, Shin CH, Park JG, Kim J, Hyeon T (2006) Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals. J Am Chem Soc 128(3):688–68910.1021/ja0565875 ↗
14. Kim J, Piao Y, Hyeon T (2009) Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chem Soc Rev 38(2):372–390. doi: 10.1039/B709883a10.1039/B709883A ↗
15. Koole R, Mulder WJM, van Schooneveld MM, Strijkers GJ, Meijerink A, Nicolay K (2009) Magnetic quantum dots for multimodal imaging. Wires Nanomed Nanobiotechnol 1(5):475–491. doi: 10.1002/Wnan.1410.1002/wnan.14 ↗
16. Labouta HI, Schneider M (2010) Tailor-made biofunctionalized nanoparticles using layer-by-layer technology. Int J Pharm 395(1–2):236–242. doi: 10.1016/J.Ijpharm.2010.05.01910.1016/j.ijpharm.2010.05.019 ↗
17. Landmark KJ, DiMaggio S, Ward J, Kelly CV, Vogt S, Hong S, Kotlyar A, Myc A, Thomas TP, Penner-Hahn JE, Baker JR, Holl MMB, Orr BG (2008) Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimers. ACS Nano 2(4):773–783. doi: 10.1021/Nn800034w10.1021/nn800034w ↗
18. Le Guevel X, Daum N, Schneider M (2011a) Synthesis and characterization of human transferrin-stabilized gold nanoclusters. Nanotechnology 22:27510310.1088/0957-4484/22/27/275103 ↗
19. Le Guevel X, Hötzer B, Jung G, Hollemeyer K, Trouillet V, Schneider M (2011b) Formation of fluorescent metal (Au, Ag) nanoclusters capped in bovine serum albumin followed by fluorescence and spectroscopy. J Phys Chem C 115(22):100955–11096310.1021/jp111820b ↗
20. Le Guevel X, Hötzer B, Jung G, Schneider M (2011c) NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles. J Mater Chem 21(9):2974–2981. doi: 10.1039/c0jm02660c10.1039/c0jm02660c ↗
21. Lee JE, Lee N, Kim H, Kim J, Choi SH, Kim JH, Kim T, Song IC, Park SP, Moon WK, Hyeon T (2010) Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J Am Chem Soc 132(2):552–557. doi: 10.1021/Ja905793q10.1021/ja905793q ↗
22. Lin CAJ, Yang TY, Lee CH, Huang SH, Sperling RA, Zanella M, Li JK, Shen JL, Wang HH, Yeh HI, Parak WJ, Chang WH (2009) Synthesis, characterization, and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications. ACS Nano 3(2):395–401. doi: 10.1021/Nn800632j10.1021/nn800632j ↗
23. Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI (2008) Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2(5):889–896. doi: 10.1021/Nn800072t10.1021/nn800072t ↗
24. Lvov Y, Decher G, Mohwald H (1993) Assembly, structural characterization, and thermal-behavior of layer-by-layer deposited ultrathin films of poly(vinyl sulfate) and poly(allylamine). Langmuir 9(2):481–48610.1021/la00026a020 ↗
25. Negishi Y, Nobusada K, Tsukuda T (2005) Glutathione-protected gold clusters revisited: bridging the gap between gold(I)-thiolate complexes and thiolate-protected gold nanocrystals. J Am Chem Soc 127(14):5261–5270. doi: 10.1021/Ja042218h10.1021/ja042218h ↗
26. Nooney R, Clifford A, LeGuevel X, Stranik O, McDonagh C, MacCraith BD (2010) Enhancing the analytical performance of immunoassays that employ metal-enhanced fluorescence. Anal Bioanal Chem 396(3):1127–1134. doi: 10.1007/S00216-009-3357-910.1007/s00216-009-3357-9 ↗
27. Quarta A, Di Corato R, Manna L, Argentiere S, Cingolani R, Barbarella G, Pellegrino T (2008) Multifunctional nanostructures based on inorganic nanoparticles and oligothiophenes and their exploitation for cellular studies. J Am Chem Soc 130(32):10545–10555. doi: 10.1021/Ja800102v10.1021/ja800102v ↗
28. Retnakumari A, Setua S, Menon D, Ravindran P, Muhammed H, Pradeep T, Nair S, Koyakutty M (2010) Molecular-receptor-specific, non-toxic, near-infrared-emitting Au cluster-protein nanoconjugates for targeted cancer imaging. Nanotechnology 21(5). Art no 055103. doi: 10.1088/0957-4484/21/5/05510310.1088/0957-4484/21/5/055103 ↗
29. Reum N, Fink-Straube C, Klein T, Hartmann RW, Lehr CM, Schneider M (2010) Multilayer coating of gold nanoparticles with drug-polymer coadsorbates. Langmuir 26(22):16901–16908. doi: 10.1021/La103109b10.1021/la103109b ↗
30. Schneider G, Decher G (2008) Functional core/shell nanoparticles via layer-by-layer assembly. Investigation of the experimental parameters for controlling particle aggregation and for enhancing dispersion stability. Langmuir 24(5):1778–1789. doi: 10.1021/La702183710.1021/la7021837 ↗
31. Schonhoff M (2003) Self-assembled polyelectrolyte multilayers. Curr Opin Colloid Interface Sci 8(1):86–95. doi: 10.1016/S1359-0294(03)00003-710.1016/S1359-0294(03)00003-7 ↗
32. Shenoy DB, Antipov AA, Sukhorukov GB, Mohwald H (2003) Layer-by-layer engineering of biocompatible, decomposable core-shell structures. Biomacromolecules 4(2):265–272. doi: 10.1021/Bm025661y10.1021/bm025661y ↗
33. Simms GA, Padmos JD, Zhang P (2009) Structural and electronic properties of protein/thiolate-protected gold nanocluster with “staple” motif: A XAS, L-DOS, and XPS study. J Chem Phys 131(21):214703(214701)–214703(214709). Art no 214703. doi: 10.1063/1.326878210.1063/1.3268782 ↗
34. Sukhorukov GB, Mohwald H (2007) Multifunctional cargo systems for biotechnology. Trends Biotechnol 25(3):93–98. doi: 10.1016/J.Tibtech.2006.12.00710.1016/j.tibtech.2006.12.007 ↗
35. Sun JQ, Gao MY, Feldmann J (2001) Electric field directed layer-by-layer assembly of highly fluorescent CdTe nanoparticles. J Nanosci Nanotechnol 1(2):133–136. doi: 10.1166/Jnn.2001.02910.1166/jnn.2001.029 ↗
36. Sun B, Zhang Y, Gu KJ, Shen QD, Yang Y, Song H (2009) Layer-by-layer assembly of conjugated polyelectrolytes on magnetic nanoparticle surfaces. Langmuir 25(10):5969–5973. doi: 10.1021/La804217w10.1021/la804217w ↗
37. Tamanaha CR, Mulvaney SP, Rife JC, Whitman LJ (2008) Magnetic labeling, detection, and system integration. Biosens Bioelectron 24(1):1–13. doi: 10.1016/J.Bios.2008.02.00910.1016/j.bios.2008.02.009 ↗
38. Veiseh O, Sun C, Gunn J, Kohler N, Gabikian P, Lee D, Bhattarai N, Ellenbogen R, Sze R, Hallahan A, Olson J, Zhang MQ (2005) Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett 5(6):1003–1008. doi: 10.1021/Nl050256910.1021/nl0502569 ↗
39. Wang Y, Angelatos AS, Caruso F (2008) Template synthesis of nanostructured materials via layer-by-layer assembly. Chem Mater 20(3):848–858. doi: 10.1021/Cm702481310.1021/cm7024813 ↗
40. Whitney AV, Elam JW, Zou SL, Zinovev AV, Stair PC, Schatz GC, Van Duyne RP (2005) Localized surface plasmon resonance nanosensor: a high-resolution distance-dependence study using atomic layer deposition. J Phys Chem B 109(43):20522–20528. doi: 10.1021/Jp054065610.1021/jp0540656 ↗
41. Wu ZK, Jin RC (2010) On the ligand’s role in the fluorescence of gold nanoclusters. Nano Lett 10(7):2568–2573. doi: 10.1021/Nl101225f10.1021/nl101225f ↗
42. Xie JP, Zheng YG, Ying JY (2009) Protein-directed synthesis of highly fluorescent gold nanoclusters. J Am Chem Soc 131(3):888–889. doi: 10.1021/Ja806804u10.1021/ja806804u ↗
43. Yang J, Lim EK, Lee HJ, Park J, Lee SC, Lee K, Yoon HG, Suh JS, Huh YM, Haam S (2008) Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection. Biomaterials 29(16):2548–2555. doi: 10.1016/J.Biomaterials.2007.12.03610.1016/j.biomaterials.2007.12.036 ↗
44. Yoo D, Shiratori SS, Rubner MF (1998) Controlling bilayer composition and surface wettability of sequentially adsorbed multilayers of weak polyelectrolytes. Macromolecules 31(13):4309–431810.1021/ma9800360 ↗
45. Zhang JG, Xu SQ, Kumacheva E (2005) Photogeneration of fluorescent silver nanoclusters in polymer microgels. Adv Mater 17(19):2336. doi: 10.1002/Adma.20050106210.1002/adma.200501062 ↗
46. Zhang LH, Liu BF, Dong SJ (2007) Bifunctional nanostructure of magnetic core luminescent shell and its application as solid-state electrochemiluminescence sensor material. J Phys Chem B 111(35):10448–10452. doi: 10.1021/Jp073442710.1021/jp0734427 ↗
47. Zheng J, Petty JT, Dickson RM (2003) High quantum yield blue emission from water-soluble Au-8 nanodots. J Am Chem Soc 125(26):7780–7781. doi: 10.1021/Ja035473v10.1021/ja035473v ↗
48. Zheng J, Nicovich PR, Dickson RM (2007) Highly fluorescent noble-metal quantum dots. Annu Rev Phys Chem 58:409–431. doi: 10.1146/Annurev.Physchem.58.032806.10454610.1146/annurev.physchem.58.032806.104546 ↗
49. Zhu M, Aikens CM, Hollander FJ, Schatz GC, Jin R (2008) Correlating the crystal structure of a thiol-protected Au-25 cluster and optical properties. J Am Chem Soc 130(18):5883. doi: 10.1021/Ja801173r10.1021/ja801173r ↗