Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages
Source abstract
Abstract
Although nanomaterials are used in an increasing number of commodities, the relationships between their immunotoxicity and physicochemical properties such as size or surface characteristics are not fully understood. Here we demonstrated that pretreatment with amorphous silica particles (SPs) of various sizes (diameters of 10–1000 nm), with or without amine surface modification, significantly decreased interleukin 6 production by RAW264.7 macrophages following lipopolysaccharide or peptidoglycan stimulation. Furthermore, nanosized, but not microsized, SPs significantly enhanced tumor necrosis factor-α production in macrophages stimulated with lipopolysaccharide. This altered cytokine response was distinct from the inflammatory responses induced by treatment with the SPs alone. Additionally, the uptake of SPs into macrophages by phagocytosis was found to be crucial for the suppression of macrophage immune response to occur, irrespective of particle size or surface modification. Together, these results suggest that SPs may not only increase susceptibility to microbial infection, but that they may also be potentially effective immunosuppressants.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Immunotoxicology and immune responses · Air Quality and Health Impacts
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (23)
Show source-provided references
1. Augustin MA, Sanguansri P (2009) Nanostructured materials in the food industry. Adv Food Nutr Res 58:183–213. doi: 10.1016/S1043-4526(09)58005-910.1016/S1043-4526(09)58005-9 ↗
2. Bang KM, Weissman DN, Wood JM, Attfield MD (2005) Tuberculosis mortality by industry in the United States, 1990–1999. Int J Tuberc Lung Dis 9:437–442
3. Beamer CA, Holian A (2008) Silica suppresses toll-like receptor ligand-induced dendritic cell activation. FASEB J 22:2053–2063. doi: 10.1096/fj.07-09529910.1096/fj.07-095299 ↗
4. Bowman DM, van Calster G, Friedrichs S (2010) Nanomaterials and regulation of cosmetics. Nat Nanotechnol 5:92. doi: 10.1038/nnano.2010.1210.1038/nnano.2010.12 ↗
5. Castillo PM, Herrera JL, Fernandez-Montesinos R, Caro C, Zaderenko AP, Mejias JA, Pozo D (2008) Tiopronin monolayer-protected silver nanoparticles modulate IL-6 secretion mediated by toll-like receptor ligands. Nanomedicine (Lond) 3:627–635. doi: 10.2217/17435889.3.5.62710.2217/17435889.3.5.627 ↗
6. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274:10689–1069210.1074/jbc.274.16.10689 ↗
7. Cowie RL (1994) The epidemiology of tuberculosis in gold miners with silicosis. Am J Respir Crit Care Med 150:1460–1462. doi: 10.1164/ajrccm.150.5.795257710.1164/ajrccm.150.5.7952577 ↗
8. Hirota K, Terada H (2012) Endocytosis of particle formulations by macrophages and its application to clinical treatment. Molecular regulation of endocytosis, INTECH Open Access Publisher, Rijeka 10.5772/4582010.5772/45820 ↗
9. Kusaka T, Nakayama M, Nakamura K, Ishimiya M, Furusawa E, Ogasawara K (2014) Effect of silica particle size on macrophage inflammatory responses. PLoS One 9:e92634. doi: 10.1371/journal.pone.009263410.1371/journal.pone.0092634 ↗
10. Morishige T et al (2010) The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture. Biomaterials 31:6833–6842. doi: 10.1016/j.biomaterials.2010.05.03610.1016/j.biomaterials.2010.05.036 ↗
11. Morishige T et al (2012) Suppression of nanosilica particle-induced inflammation by surface modification of the particles. Arch Toxicol 86:1297–1307. doi: 10.1007/s00204-012-0823-510.1007/s00204-012-0823-5 ↗
12. Nabeshi H et al (2011) Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages. Nanoscale Res Lett 6:464. doi: 10.1186/1556-276X-6-46410.1186/1556-276X-6-464 ↗
13. Osadchaia AI, Prokopchenko SF, Kostiuchenko IL, Mikhnovskaia ND, Vasilevskaia IA (1990) The choice of the optimal aeration conditions for the stab cultivation of Bacillus thuringiensis H14 266/2-1. Mikrobiol Zh 52:34–39
14. Poland CA et al (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423–428. doi: 10.1038/nnano.2008.11110.1038/nnano.2008.111 ↗
15. Poltorak A et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085–208810.1126/science.282.5396.2085 ↗
16. Rees D, Murray J (2007) Silica, silicosis and tuberculosis. Int J Tuberc Lung Dis 11:474–484
17. Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 274:17406–1740910.1074/jbc.274.25.17406 ↗
18. Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K (2009) Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol 6:20. doi: 10.1186/1743-8977-6-2010.1186/1743-8977-6-20 ↗
19. Takeuchi O et al (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443–45110.1016/S1074-7613(00)80119-3 ↗
20. Tsai CY, Lu SL, Hu CW, Yeh CS, Lee GB, Lei HY (2012) Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages. J Immunol 188:68–76. doi: 10.4049/jimmunol.110034410.4049/jimmunol.1100344 ↗
21. Yamashita K et al (2011) Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 6:321–328. doi: 10.1038/nnano.2011.4110.1038/nnano.2011.41 ↗
22. Yoshida T et al (2012) Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells. Biochem Biophys Res Commun 427:748–752. doi: 10.1016/j.bbrc.2012.09.13210.1016/j.bbrc.2012.09.132 ↗
23. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via toll-like receptor 2. J Immunol 163:1–510.4049/jimmunol.163.1.1 ↗