An albumin-based gold nanocomposites as potential dual mode CT/MRI contrast agent
Source abstract
Abstract
In pursuit of the biological detection applications, recent years have witnessed the prosperity of novel multi-modal nanoprobes. In this study, biocompatible bovine serum albumin (BSA)-coated gold nanoparticles (Au NPs) containing Gd (III) as the contrast agent for both X-ray CT and T1-weighted MR imaging is reported. Firstly, the Au NPs with BSA coating (Au@BSA) was prepared through a moderate one-pot reduction route in the presence of hydrazine hydrate as reducer. Sequentially, the BSA coating enables modification of diethylenetriaminepentaacetic acid (DTPA) as well as targeting reagent hyaluronic acid (HA), and further chelation of Gd (III) ions led to the formation of biomimetic nanoagent HA-targeted Gd-Au NPs (HA-targeted Au@BSA-Gd-DTPA). Several techniques were used to thoroughly characterize the formed HA-targeted Gd-Au NPs. As expected, the as-prepared nanoagent with mean diameter of 13.82 nm exhibits not only good colloid stablility and water dispersibility, but also satisfying low cytotoxicity and hemocompatibility in the tested concentration range. Additionally, for the CT phantoms, the obtained nanocomplex shows an improved contrast in CT scanning than that of Au@BSA as well as small molecule iodine-based CT contrast agents such as iopromide. Meanwhile, for the T1-weighted MRI images, there is a linear increase of contrast with concentration of Gd for the two cases of HA-targeted Gd-Au NPs and Magnevist. Strikingly, the nanoagent we explored displays a relatively higher r1 relaxivity than that of commercial MR contrast agents. Therefore, this newly constructed nanoagent could be used as contrast agents for synergistically enhanced X-ray CT and MR phantoms, holding promising potential for future biomedical applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · MRI in cancer diagnosis · Advanced MRI Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (40)
Show source-provided references
1. Alric C, Taleb J, Duc GL, Mandon C, Billotey C, Meur-Herland AL, Brochard T, Vocanson F, Janier M, Perriat P, Roux S, Tillement O (2008) Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. J Am Chem Soc 130(18):5908–5915. https://doi.org/10.1021/ja078176p10.1021/ja078176p ↗
2. Badea C, Drangova M, Holdsworth D, Johnson G (2008) In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol 53(19):R319–R350. https://doi.org/10.1088/0031-9155/53/19/R0110.1088/0031-9155/53/19/R01 ↗
3. Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF, Maffioli L, Moncayo R, Mortelmans L, Reske SN (2003) FDG-PET: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging 30(12):1–1. https://doi.org/10.1007/s00259-003-1355-210.1007/s00259-003-1355-2 ↗
4. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 99(9):2293–2352. https://doi.org/10.1021/cr980440x10.1021/cr980440x ↗
5. Chen J, Sun Y, Chen Q, Wang L, Wang S, Tang Y, Shi X, Wang H (2016) Multifunctional gold nanocomposites designed for targeted CT/MR/optical trimodal imaging of human non-small cell lung cancer cells. Nano 8(28):13568–13573. https://doi.org/10.1039/c6nr03143a10.1039/c6nr03143a ↗
6. Chen Q, Li K, Wen S, Liu H, Peng C, Cai H, Shen M, Zhang G, Shi X (2013) Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 34(21):5200–5209. https://doi.org/10.1016/j.biomaterials.2013.03.00910.1016/j.biomaterials.2013.03.009 ↗
7. Chen Q, Wang H, Liu H, Wen S, Peng C, Shen M, Zhang G, Shi X (2015) Multifunctional dendrimer-entrapped gold nanoparticles modified with RGD peptide for targeted computed tomography/magnetic resonance dual-modal imaging of tumors. Anal Chem 87(7):3949–3956. https://doi.org/10.1021/acs.analchem.5b0013510.1021/acs.analchem.5b00135 ↗
8. Cheng KK, Chan PS, Fan S, Kwan SM, Yeung KL, Wáng YXJ, Chow AHL, Wu EX, Baum L (2015) Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer’s disease mice using magnetic resonance imaging (MRI). Biomaterials 44:155–172. https://doi.org/10.1016/j.biomaterials.2014.12.00510.1016/j.biomaterials.2014.12.005 ↗
9. Cherry SR (2009) Multimodality imaging: beyond PET/CT and SPECT/CT. Semin Nucl Med 39(5):348–353. https://doi.org/10.1053/j.semnuclmed.2009.03.00110.1053/j.semnuclmed.2009.03.001 ↗
10. Choi KY, Chung H, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Jeong SY (2010) Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 31(1):106–114. https://doi.org/10.1016/j.biomaterials.2009.09.03010.1016/j.biomaterials.2009.09.030 ↗
11. Debbage P, Jaschke W (2008) Molecular imaging with nanoparticles: giant roles for dwarf actors. Histochem Cell Biol 130(5):845–875. https://doi.org/10.1007/s00418-008-0511-y10.1007/s00418-008-0511-y ↗
12. Deshpande N, Needles A, Willmann JK (2010) Molecular ultrasound imaging: current status and future directions. Clin Radiol 65(7):567–581. https://doi.org/10.1016/j.crad.2010.02.01310.1016/j.crad.2010.02.013 ↗
13. Dou Y, Guo Y, Li X, Li X, Wang S, Wang L, Lv G, Zhang X, Wang H, Gong X, Chang J (2016) Size-tuning ionization to optimize gold nanoparticles for simultaneous enhanced CT imaging and radiotherapy. ACS Nano 10(2):2536–2548. https://doi.org/10.1021/acsnano.5b0747310.1021/acsnano.5b07473 ↗
14. Ghosh SK, Pal T (2007) Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles: from theory to applications. Chem Rev 107(11):4797–4862. https://doi.org/10.1021/cr068028210.1021/cr0680282 ↗
15. Gong H, Chao Y, Xiang J, Han X, Song G, Feng L, Liu J, Yang G, Chen Q, Liu Z (2016) Hyaluronidase to enhance nanoparticle-based photodynamic tumor therapy. Nano Lett 16(4):2512–2521. https://doi.org/10.1021/acs.nanolett.6b0006810.1021/acs.nanolett.6b00068 ↗
16. Hasebroock KM, Serkova NJ (2009) Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol 5(4):403–416. https://doi.org/10.1517/1742525090287379610.1517/17425250902873796 ↗
17. Hou Y et al (2012) NaGdF4 nanoparticle-based molecular probes for magnetic resonance imaging of intraperitoneal tumor xenografts in vivo. ACS Nano 7:330–33810.1021/nn304837c ↗
18. Jahanbin T, Sauriat-Dorizon H, Spearman P, Benderbous S, Korri-Youssoufi H (2015) Development of Gd (III) porphyrin-conjugated chitosan nanoparticles as contrast agents for magnetic resonance imaging. Mater Sci Eng C 52:325–33210.1016/j.msec.2015.03.007 ↗
19. Le W, Cui S, Chen X, Zhu H, Chen B, Cui Z (2016) Facile synthesis of gd-functionalized gold nanoclusters as potential mri/ct contrast agents. Nano 6:65
20. Lee H, Lee K, Kim IK, Park TG (2008) Synthesis, characterization, and in vivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes. Biomaterials 29(35):4709–4718. https://doi.org/10.1016/j.biomaterials.2008.08.03810.1016/j.biomaterials.2008.08.038 ↗
21. Li D, Yang J, Wen S, Shen M, Zheng L, Zhang G, Shi X (2017) Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles. J Mater Chem B 5(13):2395–2401. https://doi.org/10.1039/c7tb00286f10.1039/C7TB00286F ↗
22. Liu H, Shen M, Zhao J, Guo R, Cao X, Zhang G, Shi X (2012) Tunable synthesis and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy nanoparticles. Colloids Surf B Biointerfaces 94:58–67. https://doi.org/10.1016/j.colsurfb.2012.01.01910.1016/j.colsurfb.2012.01.019 ↗
23. Lusic H, Grinstaff MW (2013) X-ray-computed tomography contrast agents. Chem Rev 113(3):1641–1666. https://doi.org/10.1021/cr200358s10.1021/cr200358s ↗
24. Mao F, Wen L, Sun C, Zhang S, Wang G, Zeng J, Wang Y, Ma J, Gao M, Li Z (2016) Ultrasmall biocompatible Bi2Se3 nanodots for multimodal imaging-guided synergistic radiophotothermal therapy against cancer. ACS Nano 10(12):11145–11155. https://doi.org/10.1021/acsnano.6b0606710.1021/acsnano.6b06067 ↗
25. Peng C et al (2012) Facile formation of dendrimer-stabilized gold nanoparticles modified with diatrizoic acid for enhanced computed tomography imaging applications. Nano 4:6768–6778
26. Popovtzer R, Agrawal A, Kotov NA, Popovtzer A, Balter J, Carey TE, Kopelman R (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8(12):4593–4596. https://doi.org/10.1021/nl802911410.1021/nl8029114 ↗
27. Rieffel J, Chitgupi U, Lovell JF (2015) Recent advances in higher-order, multimodal, biomedical imaging agents. Small 11(35):4445–4461. https://doi.org/10.1002/smll.20150073510.1002/smll.201500735 ↗
28. Rolfe BE, Blakey I, Squires O, Peng H, Boase NRB, Alexander C, Parsons PG, Boyle GM, Whittaker AK, Thurecht KJ (2014) Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. J Am Chem Soc 136(6):2413–2419. https://doi.org/10.1021/ja410351h10.1021/ja410351h ↗
29. Shi F, Peng C, Yang Y, Sha Y, Shi X, Wu H (2016a) Enhanced CT imaging of human laryngeal squamous carcinoma and indirect CT lymphography imaging using PEGylated PAMAM G5·NH2-entrapped gold nanoparticles as contrast agent. Colloids Surf A Physicochem Eng Asp 497:194–204. https://doi.org/10.1016/j.colsurfa.2016.02.00510.1016/j.colsurfa.2016.02.005 ↗
30. Shi H, Wang Z, Huang C, Gu X, Jia T, Zhang A, Wu Z, Zhu L, Luo X, Zhao X, Jia N, Miao F (2016b) A functional CT contrast agent for in vivo imaging of tumor hypoxia. Small 12(29):3995–4006. https://doi.org/10.1002/smll.20160102910.1002/smll.201601029 ↗
31. Sk Md N, Kim H-K, Park J-A, Chang Y-M, Kim T-J (2010) Gold nanoparticles coated with Gd-chelate as a potential CT/MRI bimodal contrast agent. Bull Kor Chem Soc 31(5):1177–1181. https://doi.org/10.5012/bkcs.2010.31.5.117710.5012/bkcs.2010.31.5.1177 ↗
32. Tran N, Bye N, Moffat BA, Wright DK, Cuddihy A, Hinton TM, Hawley AM, Reynolds NP, Waddington LJ, Mulet X, Turnley AM, Morganti-Kossmann MC, Muir BW (2017) Dual-modality NIRF-MRI cubosomes and hexosomes: high throughput formulation and in vivo biodistribution. Mater Sci Eng C 71:584–593. https://doi.org/10.1016/j.msec.2016.10.02810.1016/j.msec.2016.10.028 ↗
33. Wang Z, Wu H, Shi H, Wang M, Huang C, Jia N (2016) A novel multifunctional biomimetic Au@BSA nanocarrier as a potential siRNA theranostic nanoplatform. J Mater Chem B 4(14):2519–2526. https://doi.org/10.1039/c5tb02326b10.1039/C5TB02326B ↗
34. Weissleder R, Pittet MJ (2008) Imaging in the era of molecular oncology. Nature 452(7187):580–589. https://doi.org/10.1038/nature0691710.1038/nature06917 ↗
35. Wen S, Li K, Cai H, Chen Q, Shen M, Huang Y, Peng C, Hou W, Zhu M, Zhang G, Shi X (2013) Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications. Biomaterials 34(5):1570–1580. https://doi.org/10.1016/j.biomaterials.2012.11.01010.1016/j.biomaterials.2012.11.010 ↗
36. Xu C, Wang Y, Zhang C, Jia Y, Luo Y, Gao X (2017) AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging. Nano 9:4620–4628
37. Yin W, Yan L, Yu J, Tian G, Zhou L, Zheng X, Zhang X, Yong Y, Li J, Gu Z, Zhao Y (2014) High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. ACS Nano 8(7):6922–6933. https://doi.org/10.1021/nn501647j10.1021/nn501647j ↗
38. Zhang B, Jin H, Li Y, Chen B, Liu S, Shi D (2012) Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. J Mater Chem 22(29):14494. https://doi.org/10.1039/c2jm30629h10.1039/c2jm30629h ↗
39. Zhang C, Li C, Liu Y, Zhang J, Bao C, Liang S, Wang Q, Yang Y, Fu H, Wang K, Cui D (2015) Gold nanoclusters-based nanoprobes for simultaneous fluorescence imaging and targeted photodynamic therapy with superior penetration and retention behavior in tumors. Adv Funct Mater 25(8):1314–1325. https://doi.org/10.1002/adfm.20140309510.1002/adfm.201403095 ↗
40. Zhao W, Wang Z, Chen L, Huang C, Huang Y, Jia N (2017) A biomimetic Au@BSA-DTA nanocomposites-based contrast agent for computed tomography imaging. Mater Sci Eng C Mater Biol Appl 78:565–570. https://doi.org/10.1016/j.msec.2017.04.12710.1016/j.msec.2017.04.127 ↗