Preparation and biodistribution of 59Fe-radiolabelled iron oxide nanoparticles
Source abstract
Abstract
We report on the 59Fe radiolabelling of iron oxide nanoparticle cores through post-synthetic isotope exchange (59Fe-IONPex) and precursor labelling (59Fe-IONPpre). Scanning electron microscopy and dynamic light scattering measurements showed no impact of radiolabelling on nanoparticle size or morphology. While incorporation efficiencies of these methods are comparable—83 and 90% for precursor labelling and post-synthetic isotope exchange, respectively—59Fe-IONPpre exhibited much higher radiochemical stability in citrated human plasma. Quantitative ex vivo biodistribution study of 59Fe-IONPpre coated with triethylene glycol was performed in Wistar rats. Following the intravenous administration, high 59Fe concentration was observed in the lung and the organs of the reticuloendothelial system such as the liver, the spleen and the femur.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Iron Metabolism and Disorders · Radiation Therapy and Dosimetry · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Balasubramaniam S, Kayandan S, Lin Y-N et al (2014) Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T 2-weighted MRI contrast. Langmuir 30:1580–1587. doi: 10.1021/la403591z10.1021/la403591z ↗
2. Bargheer D, Giemsa A, Freund B et al (2015b) The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice. Beilstein J Nanotechnol 6:111–123. doi: 10.3762/bjnano.6.1110.3762/bjnano.6.11 ↗
3. Bargheer D, Nielsen J, Gébel G et al (2015a) The fate of a designed protein corona on nanoparticles in vitro and in vivo. Beilstein J Nanotechnol 6:36–46. doi: 10.3762/bjnano.6.510.3762/bjnano.6.5 ↗
4. Bass LA, Wang M, Welch MJ, Anderson CJ (2000) In vivo transchelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver. Bioconjug Chem 11:527–532. doi: 10.1021/bc990167l10.1021/bc990167l ↗
5. Bomati-Miguel O, Miguel-Sancho N, Abasolo I et al (2014) Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects. J Nanopart Res. doi: 10.1007/s11051-014-2292-710.1007/s11051-014-2292-7 ↗
6. Boros E, Bowen AM, Josephson L et al (2015) Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles. Chem Sci 6:225–236. doi: 10.1039/C4SC02778G10.1039/C4SC02778G ↗
7. Chakravarty R, Valdovinos HF, Chen F et al (2014) Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in vivo dual-modality PET/MR imaging. Adv Mater 26:5119–5123. doi: 10.1002/adma.20140137210.1002/adma.201401372 ↗
8. Chen F, Ellison PA, Lewis CM et al (2013) Chelator-free synthesis of a dual-modality PET/MRI agent. Angew Chem Int Ed 52:13319–13323. doi: 10.1002/anie.20130630610.1002/anie.201306306 ↗
9. Ciofani G, Danti S, D’Alessandro D et al (2010) Assessing cytotoxicity of boron nitride nanotubes: interference with the MTT assay. Biochem Biophys Res Commun 394:405–411. doi: 10.1016/j.bbrc.2010.03.03510.1016/j.bbrc.2010.03.035 ↗
10. Freund B, Tromsdorf UI, Bruns OT et al (2012) A simple and widely applicable method to 59 Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies. ACS Nano 6:7318–7325. doi: 10.1021/nn302426710.1021/nn3024267 ↗
11. Glaus C, Rossin R, Welch MJ, Bao G (2010) In vivo evaluation of 64 Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. Bioconjug Chem 21:715–722. doi: 10.1021/bc900511j10.1021/bc900511j ↗
12. Hoffman D, Sun M, Yang L et al (2014) Intrinsically radiolabelled [59Fe]-SPIONs for dual MRI/radionuclide detection. Am J Nucl Med Mol Imaging 4:548–560
13. Huang G, Chen H, Dong Y et al (2013) Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics 3:116–126. doi: 10.7150/thno.541110.7150/thno.5411 ↗
14. Jin S-M, Oh S-H, Oh BJ et al (2015) Feasibility of islet magnetic resonance imaging using ferumoxytol in intraportal islet transplantation. Biomaterials 52:272–280. doi: 10.1016/j.biomaterials.2015.02.05510.1016/j.biomaterials.2015.02.055 ↗
15. Jung CSL, Heine M, Freund B et al (2016) Quantitative activity measurements of brown adipose tissue at 7 T magnetic resonance imaging after application of triglyceride-rich lipoprotein 59Fe-superparamagnetic iron oxide nanoparticle: intravenous versus intraperitoneal approach. Investig Radiol 51:194–202. doi: 10.1097/RLI.000000000000023510.1097/RLI.0000000000000235 ↗
16. Kaittanis C, Shaffer TM, Ogirala A et al (2014) Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun. doi: 10.1038/ncomms438410.1038/ncomms4384 ↗
17. Larsen BA, Haag MA, Serkova NJ et al (2008) Controlled aggregation of superparamagnetic iron oxide nanoparticles for the development of molecular magnetic resonance imaging probes. Nanotechnology 19:265102. doi: 10.1088/0957-4484/19/26/26510210.1088/0957-4484/19/26/265102 ↗
18. Lartigue L, Alloyeau D, Kolosnjaj-Tabi J et al (2013) Biodegradation of iron oxide nanocubes: high-resolution in situ monitoring. ACS Nano 7:3939–3952. doi: 10.1021/nn305719y10.1021/nn305719y ↗
19. Maity D, Kale SN, Kaul-Ghanekar R et al (2009) Studies of magnetite nanoparticles synthesized by thermal decomposition of iron(III) acetylacetonate in tri(ethylene glycol). J Magn Magn Mater 321:3093–3098. doi: 10.1016/j.jmmm.2009.05.02010.1016/j.jmmm.2009.05.020 ↗
20. Miguel-Sancho N, Bomati-Miguel O, Roca AG et al (2012) Synthesis of magnetic nanocrystals by thermal decomposition in glycol media: effect of process variables and mechanistic study. Ind Eng Chem Res 51:8348–8357. doi: 10.1021/ie300297410.1021/ie3002974 ↗
21. Mouli SK, Tyler P, McDevitt JL et al (2013) Image-guided local delivery strategies enhance therapeutic nanoparticle uptake in solid tumors. ACS Nano 7:7724–7733. doi: 10.1021/nn402311910.1021/nn4023119 ↗
22. Nguyen T-K, Duong HTT, Selvanayagam R et al (2015) Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibiotic efficacy. Sci Rep 5:18385. doi: 10.1038/srep1838510.1038/srep18385 ↗
23. Peiris PM, Abramowski A, Mcginnity J et al (2015) Treatment of invasive brain tumors using a chain-like nanoparticle. Cancer Res 75:1356–1365. doi: 10.1158/0008-5472.CAN-14-154010.1158/0008-5472.CAN-14-1540 ↗
24. Ramachandra Kurup Sasikala A, Thomas RG, Unnithan AR et al (2016) Multifunctional nanocarpets for cancer theranostics: remotely controlled graphene nanoheaters for thermo-chemosensitisation and magnetic resonance imaging. Sci Rep 6:20543. doi: 10.1038/srep2054310.1038/srep20543 ↗
25. Rizzitelli S, Giustetto P, Cutrin JC et al (2015) Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound. J Control Release 202:21–30. doi: 10.1016/j.jconrel.2015.01.02810.1016/j.jconrel.2015.01.028 ↗
26. Roy E, Patra S, Madhuri R, Sharma PK (2016) Stimuli-responsive poly(N-isopropyl acrylamide)-co-tyrosine@gadolinium: iron oxide nanoparticle-based nanotheranostic for cancer diagnosis and treatment. Colloids Surf B Biointerfaces 142:248–258. doi: 10.1016/j.colsurfb.2016.02.05310.1016/j.colsurfb.2016.02.053 ↗
27. Sandiford L, Phinikaridou A, Protti A et al (2013) Bisphosphonate-anchored PEGylation and radiolabeling of superparamagnetic iron oxide: long-circulating nanoparticles for in vivo multimodal (T1 MRI-SPECT) imaging. ACS Nano 7:500–512. doi: 10.1021/nn304605510.1021/nn3046055 ↗
28. Sharma R, Xu Y, Kim SW et al (2013) Carbon-11 radiolabeling of iron-oxide nanoparticles for dual-modality PET/MR imaging. Nanoscale 5:7476. doi: 10.1039/c3nr02519e10.1039/c3nr02519e ↗
29. Soenen SJH, Himmelreich U, Nuytten N et al (2010) Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality. Small 6:2136–2145. doi: 10.1002/smll.20100076310.1002/smll.201000763 ↗
30. Thorek DLJ, Ulmert D, Diop N-FM et al (2014) Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle. Nat Commun. doi: 10.1038/ncomms409710.1038/ncomms4097 ↗
31. Torres Martin de Rosales R, Tavaré R, Glaria A et al (2011a) 99m Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug Chem 22:455–465. doi: 10.1021/bc100483k10.1021/bc100483k ↗
32. Torres Martin de Rosales R, Tavaré R, Paul RL et al (2011b) Synthesis of 64 CuII-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent. Angew Chem Int Ed 50:5509–5513. doi: 10.1002/anie.20100789410.1002/anie.201007894 ↗
33. Wang H, Kumar R, Nagesha D et al (2015) Integrity of 111In-radiolabeled superparamagnetic iron oxide nanoparticles in the mouse. Nucl Med Biol 42:65–70. doi: 10.1016/j.nucmedbio.2014.08.01410.1016/j.nucmedbio.2014.08.014 ↗
34. Wörle-Knirsch JM, Pulskamp K, Krug HF (2006) Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 6:1261–1268. doi: 10.1021/nl060177c10.1021/nl060177c ↗
35. Wu C, Xu Y, Yang L et al (2015) Negatively charged magnetite nanoparticle clusters as efficient MRI probes for dendritic cell labeling and in vivo tracking. Adv Funct Mater 25:3581–3591. doi: 10.1002/adfm.20150103110.1002/adfm.201501031 ↗
36. Xu Y, Wu C, Zhu W et al (2015) Superparamagnetic MRI probes for in vivo tracking of dendritic cell migration with a clinical 3 T scanner. Biomaterials 58:63–71. doi: 10.1016/j.biomaterials.2015.04.01610.1016/j.biomaterials.2015.04.016 ↗
37. Yassine O, Zaher A, Li EQ et al (2016) Highly efficient thermoresponsive nanocomposite for controlled release applications. Sci Rep 6:28539. doi: 10.1038/srep2853910.1038/srep28539 ↗
38. Zeng J, Jia B, Qiao R et al (2014) In situ111In-doping for achieving biocompatible and non-leachable 111In-labeled Fe3O4 nanoparticles. Chem Commun 50:2170. doi: 10.1039/c3cc48948e10.1039/c3cc48948e ↗
39. Zhang Z-Q, Song S-C (2016) Thermosensitive/superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels for multiple cancer hyperthermia. Biomaterials 106:13–23. doi: 10.1016/j.biomaterials.2016.08.01510.1016/j.biomaterials.2016.08.015 ↗