A polymer encapsulation approach to prepare zwitterion-like, biocompatible quantum dots with wide pH and ionic stability
Source abstract
Abstract
A surface modification approach adopting polymer encapsulation was developed to prepare zwitterion-like quantum dots (ZWL-QDs). The fundamental physical, chemical, and biological properties of the ZWL-QDs were characterized. It is found that the ZWL-QDs almost preserve the quantum yield (QY) of native hydrophobic QDs in organic solvents, and also are compact in size (7 ~ 10 nm hydrodynamic diameter) and stable over wide pHs or in high salinity solutions. Further cellular study shows that the ZWL-QDs with a concentration less than 100 nM have a minimal cytotoxicity and thus are biocompatible. Characterizing and understanding these essential properties of the ZWL-QDs are an important step before employing them for various applications.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Quantum Dots Synthesis And Properties · Nanocluster Synthesis and Applications · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (24)
Show source-provided references
1. Al-Jamal WT, Kostarelos K (2011) Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc Chem Res 44:1094–110410.1021/ar200105p ↗
2. Bagalkot V, Gao X (2011) siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing. ASC Nano 5:8131–813910.1021/nn202772p ↗
3. Booth M, Peel R, Partanen R, Hondow N, Vasilca V, Jeukenb LJC, Critchley K (2013) Amphipol-encapsulated CuInS2/ZnS quantum dots with excellent colloidal stability. RSC Adv 3:20559–2056610.1039/c3ra43846e ↗
4. Breus VV, Heyes CD, Tron K, Nienhaus GU (2009) Zwitterionic biocompatible quantum dots for wide pH stability and weak non-specific binding to cells. ACS Nano 3:2573–258010.1021/nn900600w ↗
5. Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281:2013–201610.1126/science.281.5385.2013 ↗
6. Delehanty J, Blanco-Canosa J, Bradburne C, Susumu K, Stewart M, Prasuhn D, Dawson P, Medintz I (2013) Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides. Chem Commun 49:7878–788010.1039/c3cc42781a ↗
7. Giljohann DA, Seferos DS, Prigodich AE, Patel PC, Mirkin CA (2009) Gene regulation with polyvalent siRNA-nanoparticle conjugates. J Am Chem Soc 131:2072–207310.1021/ja808719p ↗
8. Huang L, Zhu X, Publicover NG, Hunter KW, Ahmadiantehrani M, de Bettencourt-Dias A, Bell TW (2013) Cadmium and zinc alloyed Cu-In-S nanocrystals and their optical properties. J Nanopart Res., 15, doi: 10.1007/s11051-013-2056-9 .10.1007/s11051-013-2056-9 ↗
9. Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, Ellenbogen RG, Olson JM, Zhang M (2009) PEI-PEG-Chitosan copolymer coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection. Adv Funct Mater 19:2244–225110.1002/adfm.200801844 ↗
10. Lee H, Kim IK, Park TG (2010) Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis. Bioconjugate Chem 21:289–29510.1021/bc900342p ↗
11. Lees E, Nguyen T, Clayton A, Mulvaney P (2009) The preparation of colloidally stable, water-soluble, biocompatible, semiconductor nanocrystals with a small hydrodynamic diameter. ACS Nano 3(5):1121–112810.1021/nn900144n ↗
12. Liu X, Huang H, Liu G, Zhou W, Chen Y, Jin Q, Ji J (2013) Multidentate zwitterionic chitosan oligosaccharide modified gold nanoparticles: stability, biocompatibility and cell interactions. Nanoscale 5:3982–399110.1039/c3nr00284e ↗
13. Mei B, Susumu K, Medintz I, Delehanty J, Mountziaris T, Mattoussi H (2008) Modular poly (ethylene glycol) ligands for biocompatible semiconductor and gold nanocrystals with extended pH and ionic stability. J Mater Chem 18:4949–495810.1039/b810488c ↗
14. Muro E, Pons T, Lequeux N, Fragola A, Sanson N, Lenkei Z, Dubertret B (2010) Small and stable sulfobetaine zwitterionic quantum dots for functional live-cell imaging. J Am Chem Soc 132:4556–455710.1021/ja1005493 ↗
15. Muro E, Fragola A, Pons T, Lequeux N, Ioannou A, Skourides P, Dubertret B (2012) Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells. Small 8:1029–103710.1002/smll.201101787 ↗
16. Resch-Genger U, Grabolle M, Cavaliere-Jaricot S, Nitschke R, Nann T (2008) Quantum dots versus organic dyes as fluorescent labels. Nat Methods 5:763–77510.1038/nmeth.1248 ↗
17. Sperling RA, Parak WJ (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Phil Trans R Soc A 368:1333–138310.1098/rsta.2009.0273 ↗
18. Susumu K, Uyed H, Medintz I, Pons T, Delehanty J, Mattoussi H (2007) Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J Am Chem Soc 129:13987–1399610.1021/ja0749744 ↗
19. Uyeda H, Medintz I, Jaiswal J, Simon S, Mattoussi H (2005) Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J Am Chem Soc 127:3870–387810.1021/ja044031w ↗
20. Veiseh O, Kievit FM, Fang C, Mu N, Jana S, Leung MC, Mok H, Ellenbogen RG, Park JO, Zhang M (2010) Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Biomaterials 31:8032–804210.1016/j.biomaterials.2010.07.016 ↗
21. Yezhelyev MV, Qi L, O’Regan RM, Nie S, Gao X (2008) Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc 130:9006–901210.1021/ja800086u ↗
22. Yu W, Chang E, Falkner J, Zhang J, Al-Somali A, Sayes C, Johns J, Drezek R, Colvin V (2007) Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers. J Am Chem Soc 129:2871–287910.1021/ja067184n ↗
23. Zhou J, Wang Q, Zhang C (2013) Liposome–quantum dot complexes enable multiplexed detection of attomolar DNAs without target amplification. J Am Chem Soc 135:2056–205910.1021/ja3110329 ↗
24. Zimmer J, Kim S, Ohnishi S, Tanaka E, Frangioni J, Bawendi M (2006) Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging. J Am Chem Soc 128:2526–252710.1021/ja0579816 ↗