Evaluation of acute toxicity and copper accumulation in organs of Wistar rats, 14 days after oral exposure to copper oxide (II) nano- and microparticles
Source abstract
Abstract
Copper oxide (II) nanoparticles (CuO-NPs) have been increasingly used in products of human interest, such as coating for food packaging and wood protection. The main objective of this study was to evaluate in vivo acute toxicity of CuO-NPs after oral exposure and compare it with CuO microparticles (CuO-MPs). Female rats were orally exposed, through gavage procedure, to the analyzed materials. After 14 days of observation, hematological, biochemical, histopathological, and copper organ accumulation analyses were performed. CuO-NPs (25.17 ± 8 nm) and CuO-MPs (1.092 ± 0.52 μm) were characterized and compared regarding their acute oral toxicity. Animals treated with CuO-NPs at the dose of 2000 mg kg−1 presented changes in feces and copper hepatic accumulation. Histopathological exam of livers demonstrated hepatocyte binucleation and megalocytosis. None of the animals tested with CuO-MPs showed any alterations. Oral exposure to CuO-NPs, at the dosage of 2000 mg kg−1, may cause mild transitory liver damage, mainly resolved during a 14-day post-exposure period. Also, the nanoparticulated material showed to be more toxic than the microparticulated one.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Heavy Metal Exposure and Toxicity · Trace Elements in Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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