Changes in the physical properties of silver nanoparticles in cell culture media mediate cellular toxicity and uptake
Source abstract
Abstract
Commercially available 10- to 60-nm silver nanoparticles with different surface functional groups were tested for biological activity in different cell lines. Particle uptake and stability were examined in cell culture media to determine the correlation between particle stability, uptake, and cytotoxicity. Trends in rising toxicity with decreasing particle diameter were observed; however, correlations with particle stability or uptake were not observed. The effects of different cell culture media conditions on cellular toxicity were also measured and show a need to better understand how antibiotics, routinely used in cell culture, can transform particle surfaces and how exposure timelines are important to understand how particles that change over time might have different phases of cellular activity over their lifecycles.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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