Hazard assessment of W and Mo sulphide nanomaterials for automotive use
Source abstract
Abstract
Engineered nanomaterials (ENMs) are growing in interest and use due to the enhancements envisaged in many applications. ENM hazard identification and exposure scenarios are growing in interest too. Inhalation, ingestion and assimilation through skin during ENM production or use have to be considered as possible events, and potential ENM toxicity has to be investigated before new ENM-based products are placed on the market. To design new ENM-based additive in lubricants for automotive application, the European FP7 Project AddNano is investigating the use of fullerene-like inorganic nanomaterials, including transition metal disulphides. In this work, the potential toxicities of well-characterized pristine MoS2 and WS2 ENMs were evaluated by in vitro cellular and a cell-free chemical tests. Cytotoxicity and oxidative stress on human pulmonary epithelial cells (A549), ENM surface reactivity (free radical production and lipid peroxidation), and ENM durability in simulated biological fluids were evaluated. In all tests, WS2 did not elicit a response significantly different from the negative control. MoS2 showed a moderate cellular toxicity at the highest dose and was inert in all other circumstances. Both WS2 and MoS2 were soluble in simulated biological fluids, suggesting a short durability in vivo. The low overall biological and chemical reactivity of WS2 and MoS2 suggests that tested nanomaterials are unlikely to be an hazard, as far as human respiratory system is concerned. Data could be usefully implemented in the context of environmental risk assessment and life cycle assessment.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Lubricants and Their Additives · Corrosion Behavior and Inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Bensaid S, Deorsola FA, Marchisio DL, Russo N, Fino D (2014) Flow field simulation and mixing efficiency assessment of the multi-inlet vortex mixer for molybdenum sulfide nanoparticle precipitation. Chem Eng J 238:66–77. doi: 10.1016/j.cej.2013.09.06510.1016/j.cej.2013.09.065 ↗
2. Bouwmeester H, Lynch I, Marvin HJP, Dawson KA, Berges M, Braguer D, Byrne HJ, Casey A, Chambers G, Clift MJD, Elia G, Fernandes TF, Fjellsbo LB, Hatto P, Juillerat L, Klein C, Kreyling WG, Nickel C, Riediker M, Stone V (2011) Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology 5(1):1–11. doi: 10.3109/1743539100377526610.3109/17435391003775266 ↗
3. Cohen Y, Rallo R, Liu R, Liu HH (2013) In silico analysis of nanomaterials hazard and risk. Acc Chem Res 46(3):802–812. doi: 10.1021/Ar300049e10.1021/ar300049e ↗
4. Deorsola FA, Russo N, Blengini GA, Fino D (2012) Synthesis, characterization and environmental assessment of nanosized MoS2 particles for lubricants applications. Chem Eng J 195:1–6. doi: 10.1016/j.cej.2012.04.08010.1016/j.cej.2012.04.080 ↗
5. Dix TA, Aikens J (1993) Mechanisms and biological relevance of lipid-peroxidation initiation. Chem Res Toxicol 6(1):2–18. doi: 10.1021/Tx00031a00110.1021/tx00031a001 ↗
6. Donaldson K, Murphy FA, Duffin R, Poland CA (2010) Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Particle Fibre Toxicol 7. doi: 10.1186/1743-8977-7-510.1186/1743-8977-7-5 ↗
7. Donaldson K, Murphy F, Schinwald A, Duffin R, Poland CA (2011) Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design. Nanomedicine 6(1):143–156. doi: 10.2217/nnm.10.13910.2217/nnm.10.139 ↗
8. Feldman Y, Frey GL, Homyonfer M, Lyakhovitskaya V, Margulis L, Cohen H, Hodes G, Hutchison JL, Tenne R (1996) Bulk synthesis of inorganic fullerene-like MS(2) (M = Mo, W) from the respective trioxides and the reaction mechanism. J Am Chem Soc 118(23):5362–5367. doi: 10.1021/Ja960240810.1021/ja9602408 ↗
9. Fenoglio I, Fubini B, Ghibaudi EM, Turci F (2011) Multiple aspects of the interaction of biomacromolecules with inorganic surfaces. Adv Drug Deliv Rev 63(13):1186–1209. doi: 10.1016/j.addr.2011.08.00110.1016/j.addr.2011.08.001 ↗
10. Fino D, Deorsola F, Bensaid S, Russo N (2011) Nano-sized additive synthesis for lubricant oils and compatibility tests with after-treatment catalysts. SAE Technical Papers. doi: 10.4271/2011-24-010110.4271/2011-24-0101 ↗
11. Fubini B, Ghiazza M, Fenoglio I (2010) Physico-chemical features of engineered nanoparticles relevant to their toxicity. Nanotoxicology 4(4):347–363. doi: 10.3109/17435390.2010.50951910.3109/17435390.2010.509519 ↗
12. Fubini B, Fenoglio I, Tomatis M, Turci F (2011) Effect of chemical composition and state of the surface on the toxic response to high aspect ratio nanomaterials. Nanomedicine 6(5):899–920. doi: 10.2217/Nnm.11.8010.2217/nnm.11.80 ↗
13. Ganzlebe C, Pelsy F, Hansen SF, Corden C, Grebot B, Sobey M (2011) Review of environmental legislation for the regulatory control of nanomaterials—final report
14. Gazzano E, Turci F, Foresti E, Putzu MG, Aldieri E, Silvagno F, Lesci IG, Tomatis M, Riganti C, Romano C, Fubini B, Roveri N, Ghigo D (2007) Iron-loaded synthetic chrysotile: a new model solid for studying the role of iron in asbestos toxicity. Chem Res Toxicol 20(3):380–387. doi: 10.1021/Tx600354f10.1021/tx600354f ↗
15. Ghezzi P (2011) Role of glutathione in immunity and inflammation in the lung. Int J Gen Med 4:105–113. doi: 10.2147/IJGM.S1561810.2147/IJGM.S15618 ↗
16. Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RPF, Fubini B (2011) Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24(1):99–110. doi: 10.1021/Tx100300310.1021/tx1003003 ↗
17. Ghigo D, Aldieri E, Todde R, Costamagna C, Garbarino G, Pescarmona G, Bosia A (1998) Chloroquine stimulates nitric oxide synthesis in murine, porcine and human endothelial cells. J Clin Invest 3(102):595–605. doi: 10.1172/JCI105210.1172/JCI1052 ↗
18. Groppo C, Tomatis M, Turci F, Gazzano E, Ghigo D, Compagnoni R, Fubini B (2005) Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: identification and characterization. J Toxicol Environ Health A 68(1):1–19. doi: 10.1080/1528739059052386710.1080/15287390590523867 ↗
19. Halliwell B, Chirico S (1993) Lipid-peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 57(5):S715–S72510.1093/ajcn/57.5.715S ↗
20. Hsieh HJ, Liu CA, Huang B, Tseng AHH, Wang DL (2014) Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci 21. doi: 10.1186/1423-0127-21-310.1186/1423-0127-21-3 ↗
21. Jorens PG, Matthys KE, Bult H (1995) Modulation of nitric-oxide synthase activity in macrophages. Mediators Inflamm 4(2):75–89. doi: 10.1155/S096293519500013510.1155/S0962935195000135 ↗
22. Laroux FS, Pavlick KP, Hines IN, Kawachi S, Harada H, Bharwani S, Hoffman JM, Grisham MB (2001) Role of nitric oxide in inflammation. Acta Physiol Scand 173(1):113–118. doi: 10.1046/j.1365-201X.2001.00891.x10.1046/j.1365-201X.2001.00891.x ↗
23. Lison D, Carbonnelle P, Mollo L, Lauwerys R, Fubini B (1995) Physicochemical mechanism of the interaction between cobalt metal and carbide particles to generate toxic activated oxygen species. Chem Res Toxicol 8(4):600–606. doi: 10.1021/Tx00046a01510.1021/tx00046a015 ↗
24. Lison D, Laloy J, Corazzari I, Muller J, Rabolli V, Panin N, Huaux F, Fenoglio I, Fubini B (2009) Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity. Toxicol Sci 108(2):472–481. doi: 10.1093/toxsci/kfp01410.1093/toxsci/kfp014 ↗
25. Margulis L, Salitra G, Tenne R, Talianker M (1993) Nested fullerene-like structures. Nature 365(6442):113–114. doi: 10.1038/365113b010.1038/365113b0 ↗
26. Marletta MA (1993) Nitric-oxide synthase structure and mechanism. J Biol Chem 268(17):12231–1223410.1016/S0021-9258(18)31375-9 ↗
27. Marques MRC, Loebenberg R, Almukainzi M (2011) Simulated biological fluids with possible application in dissolution testing. Dissolut Technol 18(3):15–2810.14227/DT180311P15 ↗
28. Murphy MP (1999) Nitric oxide and cell death. Biochimica Et Biophysica Acta-Bioenergetics 1411(2–3):401–414. doi: 10.1016/S0005-2728(99)00029-810.1016/S0005-2728(99)00029-8 ↗
29. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311(5761):622–627. doi: 10.1126/science.111439710.1126/science.1114397 ↗
30. Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8(7):543–557. doi: 10.1038/Nmat244210.1038/nmat2442 ↗
31. Nel A, Xia T, Meng H, Wang X, Lin SJ, Ji ZX, Zhang HY (2013) Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 46(3):607–621. doi: 10.1021/Ar300022h10.1021/ar300022h ↗
32. Oberdorster G (2010) Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med 267(1):89–105. doi: 10.1111/j.1365-2796.2009.02187.x10.1111/j.1365-2796.2009.02187.x ↗
33. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16(6–7):437–445. doi: 10.1080/0895837049043959710.1080/08958370490439597 ↗
34. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823–839. doi: 10.1289/Ehp.733910.1289/ehp.7339 ↗
35. Podila R, Brown JM (2013) Toxicity of engineered nanomaterials: a physicochemical perspective. J Biochem Mol Toxicol 27(1):50–55. doi: 10.1002/Jbt.2144210.1002/jbt.21442 ↗
36. Polimeni M, Gazzano E, Ghiazza M, Fenoglio I, Bosia A, Fubini B, Ghigo D (2008) Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages. Chem Res Toxicol 21(4):888–894. doi: 10.1021/Tx700321310.1021/tx7003213 ↗
37. Raimondi A, Girotti G, Blengini GA, Fino D (2012) LCA of petroleum-based lubricants: state of art and inclusion of additives. Int J Life Cycle Assess 17(8):987–996. doi: 10.1007/s11367-012-0437-410.1007/s11367-012-0437-4 ↗
38. Santillo G, Deorsola FA, Bensaid S, Russo N, Fino D (2012) MoS2 nanoparticle precipitation in turbulent micromixers. Chem Eng J 207:322–328. doi: 10.1016/j.cej.2012.06.12710.1016/j.cej.2012.06.127 ↗
39. Som C, Nowack B, Krug HF, Wick P (2013) Toward the development of decision supporting tools that can be used for safe production and use of nanomaterials. Acc Chem Res 46(3):863–872. doi: 10.1021/Ar300045810.1021/ar3000458 ↗
40. Spikes H (2004) The history and mechanisms of ZDDP. Tribol Lett 17(3):469–489. doi: 10.1023/B:Tril.0000044495.26882.B510.1023/B:TRIL.0000044495.26882.b5 ↗
41. Stefaniak AB, Guilmette RA, Day GA, Hoover MD, Breysse PN, Scripsick RC (2005) Characterization of phagolysosomal simulant fluid for study of beryllium aerosol particle dissolution. Toxicol In Vitro 19(1):123–134. doi: 10.1016/j.tiv.2004.08.00110.1016/j.tiv.2004.08.001 ↗
42. Stern ST, McNeil SE (2008) Nanotechnology safety concerns revisited. Toxicol Sci 101(1):4–21. doi: 10.1093/toxsci/kfm16910.1093/toxsci/kfm169 ↗
43. Tenne R, Margulis L, Genut M, Hodes G (1992) Polyhedral and cylindrical structures of tungsten disulfide. Nature 360(6403):444–446. doi: 10.1038/360444a010.1038/360444a0 ↗
44. Turci F, Colonna M, Tomatis M, Mantegna S, Cravotto G, Gulino G, Aldieri E, Ghigo D, Fubini B (2012) Surface reactivity and cell responses to chrysotile asbestos nanofibers. Chem Res Toxicol 25(4):884–894. doi: 10.1021/Tx200501910.1021/tx2005019 ↗
45. Turci F, Peira E, Corazzari I, Fenoglio I, Trotta M, Fubini B (2013) Crystalline phase modulates the potency of nanometric TiO2 to adhere to and perturb the stratum corneum of porcine skin under indoor light. Chem Res Toxicol 26(10):1579–1590. doi: 10.1021/Tx400285j10.1021/tx400285j ↗
46. Unfried K, Albrecht C, Klotz LO, Von Mikecz A, Grether-Beck S, Schins RPF (2007) Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1(1):52–71. doi: 10.1080/0022293070131493210.1080/00222930701314932 ↗
47. Vandeputte C, Guizon I, Genestie-denis I, Vannier B, Lorenzon G (1994) A microtiter assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell Biol Toxicol 10:415–42110.1007/BF00755791 ↗
48. Wang JF, Gerlach JD, Savage N, Cobb GP (2013) Necessity and approach to integrated nanomaterial legislation and governance. Sci Total Environ 442:56–62. doi: 10.1016/j.scitotenv.2012.09.07310.1016/j.scitotenv.2012.09.073 ↗
49. Xia T, Malasarn D, Lin SJ, Ji ZX, Zhang HY, Miller RJ, Keller AA, Nisbet RM, Harthorn BH, Godwin HA, Lenihan HS, Liu R, Gardea-Torresdey J, Cohen Y, Madler L, Holden PA, Zink JI, Nel AE (2013) Implementation of a multidisciplinary approach to solve complex nano EHS problems by the UC center for the environmental implications of nanotechnology. Small 9(9–10):1428–1443. doi: 10.1002/smll.20120170010.1002/smll.201201700 ↗
50. Zhang HY, Ji ZX, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin SJ, Wang X, Liao YP, Wang MY, Li LJ, Rallo R, Damoiseaux R, Telesca D, Madler L, Cohen Y, Zink JI, Nel AE (2012) Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6(5):4349–4368. doi: 10.1021/Nn301008710.1021/nn3010087 ↗