Titanium-doped cerium oxide nanoparticles protect cells from hydrogen peroxide-induced apoptosis
Source abstract
Abstract
To develop new nanoparticle materials possessing anti-oxidative capacity with improved physical characteristics, we have studied titanium-doped cerium oxide (CeTiO2) nanoparticles. CeTiO2 nanoparticles had a mode diameter of 15-20 nm. These nanoparticles demonstrated catalase activity, and did not promote the activation of hemolytic or cytolytic pathways in living cells. Using surface plasmon resonance enhanced microscopy, we find that these nanoparticles associate with cells. Transmission electron microscopy studies demonstrated that these nanoparticles accumulate within the vacuolar compartment of cells. Importantly, CeTiO2 nanoparticles decrease hydrogen peroxide-mediated apoptosis of cells as judged by the reduced cleavage of a caspase 3-sensitive label. CeTiO2 nanoparticles may contribute to deflecting tissue damage in a broad spectrum of oxidant-mediated diseases, such as macular degeneration and Alzheimer's disease.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticles: synthesis and applications · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
Show source-provided references
1. Buettner KM, Rinciog CI, Mylon SE (2010) Aggregation kinetics of cerium oxide nanoparticles in monovalent and divalent electrolytes. Colloids Surf A 366:74–7910.1016/j.colsurfa.2010.05.024 ↗
2. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Liou GI, Caldwell RW (2005) Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets 6:511–52410.2174/1389450054021981 ↗
3. Cao D, Boxer LA, Petty HR (1993) Deposition of reactive oxygen metabolites onto and within living tumor cells during neutrophil-mediated antibody-dependent cellular cytotoxicity. J Cell Physiol 156:428–43610.1002/jcp.1041560227 ↗
4. Chen J, Patil S, Seal S, McGinnis JF (2006) Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol 1:142–15010.1038/nnano.2006.91 ↗
5. Clark AJ, Diamond M, Elfline M, Petty HR (2010) Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosis. Cancer Immunol Immunother 59:149–15910.1007/s00262-009-0735-2 ↗
6. Clark A, Zhu A, Sun K, Petty HR (2011) Cerium oxide and platinum nanoparticles protect cells from oxidant-mediated apoptosis. J Nanopart Res 13:5547–555510.1007/s11051-011-0544-3 ↗
7. Colon J, Herrera L, Smith J, Patil S, Komanski C, Kupelian P, Seal S, Jenkins DW, Baker CH (2009) Protection from radiation-induced pneumonitis using cerium oxide nanoparticles. Nanomedicine 5:225–23110.1016/j.nano.2008.10.003 ↗
8. Das M, Patil S, Bhargava N, Kang JF, Riedel LM, Seal S, Hickman JJ (2007) Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Biomaterials 28:1918–192510.1016/j.biomaterials.2006.11.036 ↗
9. D’Autréaux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8:813–82410.1038/nrm2256 ↗
10. Elswaifi SF, Palmieri JR, Hockey KS, Rzigalinski BA (2009) Antioxidant nanoparticles for control of infectious disease. Infect Disord Drug Targets 9:445–45210.2174/187152609788922528 ↗
11. Feng X, Sayle DC, Wang ZL, Paras MS, Santora B, Sutorik AC, Sayle TX, Yang Y, Ding Y, Wang X, Her YS (2006) Converting ceria polyhedral nanoparticles into single-crystal nanospheres. Science 312:1504–150810.1126/science.1125767 ↗
12. Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, Wang T, Feng J, Yang D, Perrett S, Yan X (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol 2:577–58310.1038/nnano.2007.260 ↗
13. George S, Lin S, Ji Z, Thomas CR, Li L, Mecklenburg M, Meng H, Wang X, Zhang H, Xia T, Hohman JN, Lin S, Zink JI, Weiss PS, Nel AE (2012) Surface defects on plate-shaped silver nanoparticles contribute to its hazard potential in a fish gill cell line and zebrafish embryos. ACS Nano 6:3745–375910.1021/nn204671v ↗
14. Kanwar M, Chan PS, Kern TS, Kowluru RA (2007) Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48:3805–381110.1167/iovs.06-1280 ↗
15. Kawaji T, Elner VM, Yang DL, Clark A, Petty HR (2011) Nuclear translocation of glyceraldehyde 3-phosphate dehydrogenase in human retinal pigment epithelium induced by oxidative stress. Redox Reports 16:24–2610.1179/174329211X12968219310710 ↗
16. Keller AA, Wang H, Zhou D, Lenihan HS, Cherr G, Cardinale BJ, Miller R, Ji Z (2010) Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices. Environ Sci Technol 44:1962–196710.1021/es902987d ↗
17. Korsvik C, Patil S, Seal S, Self WT (2007) Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun (Camb) 14:1056–105810.1039/b615134e ↗
18. Kowluru RA, Kowluru V, Xiong Y, Ho YS (2006) Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Radic Biol Med 41:1191–119610.1016/j.freeradbiomed.2006.01.012 ↗
19. Mahmoudi M, Lynch I, Ejtehadi MR, Monopoli MP, Bombelli FB, Laurent S (2011) Protein-nanoparticle interactions: opportunities and challenges. Chem Rev 111:5610–563710.1021/cr100440g ↗
20. Mahmoudi M, Saeedi-Eslami SN, Shokrgozar MA, Azadmanesh K, Hassanlou M, Kalhor HR, Burtea C, Rothen-Rutishauser B, Laurent S, Sheibani S, Vali H (2012) Cell “vision”: complementary factor of protein corona in nanotoxicology. Nanoscale 4:5461–546810.1039/c2nr31185b ↗
21. McCubrey JA, Lahair MM, Franklin RA (2006) Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 8:1775–178910.1089/ars.2006.8.1775 ↗
22. Ndozangue-Touriguine O, Hamelin J, Bréard J (2008) Cytoskeleton and apoptosis. Biochem Pharmacol 76:11–1810.1016/j.bcp.2008.03.016 ↗
23. Niu J, Azfer A, Rogers LM, Wang X, Kolattukudy PE (2007) Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy. Cardiovasc Res 73:549–55910.1016/j.cardiores.2006.11.031 ↗
24. Ohno Y, Gallin JI (1985) Diffusion of extracellular hydrogen peroxide into intracellular compartments of human neutrophils. Studies utilizing the inactivation of myeloperoxidase by hydrogen peroxide and azide. J Biol Chem 260:8438–844610.1016/S0021-9258(17)39493-0 ↗
25. Osborn NM (2008) Involvement of oxidative stress in the pathogenesis of glaucoma. In: Zierhut M, Cadenas E, Rao NA (eds) Free Radicals in Ophthalmic Disorders. Informa Healthcare, New York
26. Pal S, Tak YK, Song JM (2007) Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Appl Environ Microbiol 73:1712–172010.1128/AEM.02218-06 ↗
27. Petty HR, Francis JW (1985) Novel fluorescence method to visualize antibody-dependent hydrogen peroxide-associated “killing” of liposomes by phagocytes. Biophys J 47:837–84010.1016/S0006-3495(85)83987-4 ↗
28. Schubert D, Dargusch R, Raitano J, Chan S-W (2006) Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem Biophys Res Comm 342:86–9110.1016/j.bbrc.2006.01.129 ↗
29. Sebbagh M, Renvoizé C, Hamelin J, Riché N, Bertoglio J, Bréard J (2001) Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 3:346–35210.1038/35070019 ↗
30. Singh N, Cohen CA, Rzigalinski BA (2007) Treatment of neurodegenerative disorders with radical nanomedicine. Ann N Y Acad Sci 1122:219–23010.1196/annals.1403.015 ↗
31. Tarnuzzer RW, Colon J, Patil S, Seal S (2005) Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage. Nano Lett 5:2573–257710.1021/nl052024f ↗
32. Wu GS, Zhang J, Rao NA (1997) Peroxynitrite and oxidative damage in experimental autoimmune uveitis. Invest Ophthal Vis Sci 38:1333–1339
33. Zhu A, Sun K, Petty HR (2012) Titanium doping reduces superoxide dismutase activity, but not oxidase activity, of catalytic CeO2 nanoparticles. Inorg Chem Commun 15:235–23710.1016/j.inoche.2011.10.034 ↗