journal article·2009-08

Silicon nitride nanoparticles for surface-assisted laser desorption/ionization of small molecules

Mohammadreza Shariatgorji, Nahid Amini, Leopold L. Ilag

Journal of Nanoparticle Research· Volume 11· Issue 6
Publisher page

Abstract

Conventional matrix-assisted laser desorption/ionization mass spectrometry is limited to analyses of higher molecular weight compounds due to high background noise generated by the matrix in the lower mass region. Surface-assisted laser desorption/ionization (SALDI) mass spectrometry is an alternative solution to this problem. Nanoparticles, structured silicon surfaces and carbon allotropes are commonly used as SALDI surfaces. Here, for the first time, we demonstrate the application of silicon nitride nanoparticles as a suitable medium for laser desorption/ionization of small drug molecules.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Mass Spectrometry Techniques and Applications · Ion-surface interactions and analysis · Analytical chemistry methods development

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (15)

Show source-provided references
1. Ayorinde FO, Hambright P, Porter TN, Keith QL (1999) Use of meso-tetrakis(pentafluorophenyl)porphyrin as a matrix for low molecular weight alkylphenol ethoxylates in laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 13:2474–2479. doi: 10.1002/(SICI)1097-0231(19991230)13:24<2474::AID-RCM814>3.0.CO;2-010.1002/(SICI)1097-0231(19991230)13:24<2474::AID-RCM814>3.0.CO;2-0 ↗
2. Chiu TC, Chang LC, Chiang CK, Chang HT (2008) Determining estrogens using surface-assisted laser desorption/ionization mass spectrometry with silver nanoparticles as the matrix. J Am Soc Mass Spectrom 19:1343–1346. doi: 10.1016/j.jasms.2008.06.00610.1016/j.jasms.2008.06.006 ↗
3. Fenselau C, Demirev PA (2001) Characterization of intact microorganisms by MALDI mass spectrometry. Mass Spectrom Rev 20:157–171. doi: 10.1002/mas.1000410.1002/mas.10004 ↗
4. Grant DC, Helleur RJ (2007) Surfactant-mediated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules. Rapid Commun Mass Spectrom 21:837–845. doi: 10.1002/rcm.289910.1002/rcm.2899 ↗
5. Hall BJ, Goolsby B, Brodbelt JS (1999) Solid-phase extraction in conjunction with matrix-assisted laser desorption ionization/quadruple ion trap mass spectrometry for the determination of benzoylecgonine in urine. Appl Spectrosc 53:1361–1366. doi: 10.1366/000370299194597510.1366/0003702991945975 ↗
6. Han M, Sunner J (2000) An activated carbon substrate surface for laser desorption mass spectrometry. J Am Soc Mass Spectrom 11:644–649. doi: 10.1016/S1044-0305(00)00129-X10.1016/S1044-0305(00)00129-X ↗
7. Hua L, Chen J, Ge L, Tan SN (2007) Silver nanoparticles as matrix for laser desorption/ionization mass spectrometry of peptides. J Nanopart Res 9:1133–1138. doi: 10.1007/s11051-007-9244-410.1007/s11051-007-9244-4 ↗
8. Pan C, Xu S, Hu L, Su X, Ou J, Zou H, Guo Z, Zhang Y, Guo B (2005) Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF-MS. J Am Soc Mass Spectrom 16:883–892. doi: 10.1016/j.jasms.2005.03.00910.1016/j.jasms.2005.03.009 ↗
9. Peterson DS (2007) Matrix-free methods for laser desorption/ionization mass spectrometry. Mass Spectrom Rev 26:19–34. doi: 10.1002/mas.2010410.1002/mas.20104 ↗
10. Peterson DS, Luo Q, Hilder EF, Svec F, Frechet JMJ (2004) Porous polymer monolith for surface-enhanced laser desorption/ionization time-of-flight mass spectrometry of small molecules. Rapid Commun Mass Spectrom 18:1504–1512. doi: 10.1002/rcm.151510.1002/rcm.1515 ↗
11. Shariatgorji M, Amini N, Thorsen G, Crescenzi C, Ilag LL (2008) μ-Trap for the SALDI-MS screening of organic compounds prior to LC/MS analysis. Anal Chem 80:5515–5523. doi: 10.1021/ac800518610.1021/ac8005186 ↗
12. Su CL, Tseng WL (2007) Gold nanoparticles as assisted matrix for determining neutral small carbohydrates through laser desorption/ionization time-of-flight mass spectrometry. Anal Chem 79:1626–1633. doi: 10.1021/ac061747w10.1021/ac061747w ↗
13. Tanaka K, Waki H, Ido Y, Akita S, Yoshida Y, Yoshida T (1988) Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2:151–153. doi: 10.1002/rcm.129002080210.1002/rcm.1290020802 ↗
14. Watanabe T, Kawasaki H, Yonezawa T, Arakawa R (2008) Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) of low molecular weight organic compounds and synthetic polymers using zinc oxide (ZnO) nanoparticles. J Mass Spectrom 43:1063–1071. doi: 10.1002/jms.138510.1002/jms.1385 ↗
15. Wei J, Buriak JM, Siuzdak G (1999) Desorption–ionization mass spectrometry on porous silicon. Nature 399:243–246. doi: 10.1038/2040010.1038/20400 ↗