In-silico design, characterization, and liposome anchoring simulation of amphiphilic RGD peptides for enhanced nanoparticle functionalization in integrin-targeted drug delivery
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Lipid Membrane Structure and Behavior · Supramolecular Self-Assembly in Materials · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (71)
Show source-provided references
1. Sun W, Gregory DA, Zhao X (2023) Designed peptide amphiphiles as scaffolds for tissue engineering. Adv Colloid Interface Sci 314:10286610.1016/j.cis.2023.102866 ↗
2. Zhang Z, Ai S, Yang Z, Li X (2021) Peptide-based supramolecular hydrogels for local drug delivery. Adv Drug Deliv Rev 174:482–50310.1016/j.addr.2021.05.010 ↗
3. El-Tanani M, Nsairat H, Aljabali AA, Matalka II, Alkilany AM, Tambuwala MM (2024) Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer. Expert Opin Drug Deliv 21(2):309–32410.1080/17425247.2024.2311812 ↗
4. Siriwardane DA, Shakiba S, Jiang W, Mudalige T (2024) Evaluation of size-based distribution of components in VYXEOS® liposomal formulation using asymmetric flow field-flow fractionation. J Chromatogr A 1738:46548810.1016/j.chroma.2024.465488 ↗
5. Gunawan M, Boonkanokwong V (2024) Current applications of solid lipid nanoparticles and nanostructured lipid carriers as vehicles in oral delivery systems for antioxidant nutraceuticals: a review. Colloids Surf B Biointerfaces 233:11360810.1016/j.colsurfb.2023.113608 ↗
6. Arosio D, Casagrande C (2016) Advancement in integrin facilitated drug delivery. Adv Drug Deliv Rev 97:111–14310.1016/j.addr.2015.12.001 ↗
7. Bianchini F, De Santis A, Portioli E, Krauss IR, Battistini L, Curti C et al (2019) Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools. Nanomedicine Nanotechnol Biol Med 18:135–14510.1016/j.nano.2019.02.015 ↗
8. Sheikh A, Alhakamy NA, Md S, Kesharwani P (2022) Recent progress of RGD modified liposomes as multistage rocket against cancer. Front Pharmacol 12:80330410.3389/fphar.2021.803304 ↗
9. Bogdanović B, Fagret D, Ghezzi C, Montemagno C (2024) Integrin targeting and beyond: enhancing cancer treatment with dual-targeting RGD (arginine–glycine–aspartate) strategies. Pharmaceuticals 17(11):155610.3390/ph17111556 ↗
10. Javid H, Oryani MA, Rezagholinejad N, Esparham A, Tajaldini M, Karimi‐Shahri M (2024) RGD peptide in cancer targeting: benefits, challenges, solutions, and possible integrin–RGD interactions. Cancer Med 13(2):e680010.1002/cam4.6800 ↗
11. Nieberler M, Reuning U, Reichart F, Notni J, Wester H-J, Schwaiger M et al (2017) Exploring the role of RGD-recognizing integrins in cancer. Cancers 9(9):11610.3390/cancers9090116 ↗
12. Takada Y, Ye X, Simon S (2007) The integrins. Genome Biol 8:1–910.1186/gb-2007-8-5-215 ↗
13. Riaz MK, Riaz MA, Zhang X, Lin C, Wong KH, Chen X et al (2018) Surface functionalization and targeting strategies of liposomes in solid tumor therapy: a review. Int J Mol Sci 19(1):19510.3390/ijms19010195 ↗
14. Riaz MK, Zhang X, Wong KH, Chen H, Liu Q, Chen X et al (2019) Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy. Int J Nanomed :2879-902. https://doi.org/10.2147/ijn.s19221910.2147/ijn.s192219 ↗
15. Sonju JJ, Dahal A, Singh SS, Jois SD (2021) Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment. J Control Release 329:624–64410.1016/j.jconrel.2020.09.055 ↗
16. Lou B, Connor K, Sweeney K, Miller IS, O’Farrell A, Ruiz-Hernandez E et al (2019) RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells. Drug Deliv Transl Res 9(3):679–69310.1007/s13346-019-00637-y ↗
17. Patel JS, Raghavendra NM, Sajeev Kumar B (2024) Development and optimization of multivesicular gefitinib liposomal transdermal system employing lipoid S100 for breast cancer: pharmacokinetics, bioavailability, and skin irritation studies in Wistar rats. Future J Pharm Sci 10(1):15710.1186/s43094-024-00729-8 ↗
18. Patel RJ, Patel AA, Trivedi N, Pandya V, Alexander A, Patel V et al (2024) Liposomes as carrier for drug delivery in Alzheimer’s disease. Alzheimer’s Disease and Advanced Drug Delivery Strategies: Elsevier, pp 153–7910.1016/B978-0-443-13205-6.00008-X ↗
19. França VL, Bezerra EM, da Costa RF, Carvalho HF, Freire VN, Matos G (2024) Alzheimer’s disease immunotherapy and mimetic peptide design for drug development: mutation screening, molecular dynamics, and a quantum biochemistry approach focusing on Aducanumab:: Aβ2–7 binding affinity. ACS Chem Neurosci 15(19):3543–356210.1021/acschemneuro.4c00453 ↗
20. Kuri PR, Goswami P (2024) Unravelling aggregation propensity of rotavirus A VP6 expressed as E. coli inclusion bodies through in silico prediction. Sci Rep 14(1):2146410.1038/s41598-024-69896-1 ↗
21. Pritam M, Singh G, Swaroop S, Singh AK, Pandey B, Singh SP (2020) A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria. Int J Biol Macromol 158:159–17910.1016/j.ijbiomac.2020.04.191 ↗
22. Shad M, Nazir A, Usman M, Akhtar MW, Sajjad M (2024) Investigating the effect of SUMO fusion on solubility and stability of amylase-catalytic domain from Pyrococcus abyssi. Int J Biol Macromol 266:13131010.1016/j.ijbiomac.2024.131310 ↗
23. Balatti GE, Ambroggio EE, Fidelio GD, Martini MF, Pickholz M (2017) Differential interaction of antimicrobial peptides with lipid structures studied by coarse-grained molecular dynamics simulations. Molecules 22(10):177510.3390/molecules22101775 ↗
24. Gkeka P, Sarkisov L (2010) Interactions of phospholipid bilayers with several classes of amphiphilic α-helical peptides: insights from coarse-grained molecular dynamics simulations. J Phys Chem B 114(2):826–83910.1021/jp908320b ↗
25. Jain A, Globisch C, Verma S, Peter C (2019) Coarse-grained simulations of peptide nanoparticle formation: role of local structure and nonbonded interactions. J Chem Theory Comput 15(2):1453–146210.1021/acs.jctc.8b01138 ↗
26. Souza PC, Alessandri R, Barnoud J, Thallmair S, Faustino I, Grünewald F et al (2021) Martini 3: a general purpose force field for coarse-grained molecular dynamics. Nat Methods 18(4):382–38810.1038/s41592-021-01098-3 ↗
27. Grasso G, Muscat S, Rebella M, Morbiducci U, Audenino A, Danani A et al (2018) Cell penetrating peptide modulation of membrane biomechanics by molecular dynamics. J Biomech 73:137–14410.1016/j.jbiomech.2018.03.036 ↗
28. Mas-Moruno C, Rechenmacher F, Kessler H (2010) Cilengitide: the first anti-angiogenic small molecule drug candidate. Design, synthesis and clinical evaluation. Anti-cancer agents in medicinal chemistry (formerly current medicinal chemistry-anti-cancer agents) 10(10):753–76810.2174/187152010794728639 ↗
29. Oehlke J, Lorenz D, Wiesner B, Bienert M (2005) Studies on the cellular uptake of substance P and lysine‐rich, KLA‐derived model peptides. J Mol Recognit 18(1):50–5910.1002/jmr.691 ↗
30. Marciel AB, Chung EJ, Brettmann BK, Leon L (2017) Bulk and nanoscale polypeptide based polyelectrolyte complexes. Adv Colloid Interface Sci 239:187–19810.1016/j.cis.2016.06.012 ↗
31. Barros SM, Whitaker SK, Sukthankar P, Avila LA, Gudlur S, Warner M et al (2016) A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules. Arch Biochem Biophys 596:22–4210.1016/j.abb.2016.02.027 ↗
32. Wickline SA, Hou KK, Pan H (2023) Peptide-based nanoparticles for systemic extrahepatic delivery of therapeutic nucleotides. Int J Mol Sci 24(11):945510.3390/ijms24119455 ↗
33. Chen Q, Wang H, Liu H, Wen S, Peng C, Shen M et al (2015) Multifunctional dendrimer-entrapped gold nanoparticles modified with RGD peptide for targeted computed tomography/magnetic resonance dual-modal imaging of tumors. Anal Chem 87(7):3949–395610.1021/acs.analchem.5b00135 ↗
34. Grage SL, Afonin S, Kara S, Buth G, Ulrich AS (2016) Membrane thinning and thickening induced by membrane-active amphipathic peptides. Front Cell Dev Biol 4:6510.3389/fcell.2016.00065 ↗
35. Case DA, Aktulga HM, Belfon K, Cerutti DS, Cisneros GA, Cruzeiro VWD et al (2023) AmberTools. J Chem Inf Model 63(20):6183–619110.1021/acs.jcim.3c01153 ↗
36. Anila S, Samsonov SA (2024) Benchmarking water models in molecular dynamics of protein–glycosaminoglycan complexes. J Chem Inf Model 64(5):1691–170310.1021/acs.jcim.4c00030 ↗
37. Kaus JW, Pierce LT, Walker RC, McCammon JA (2013) Improving the efficiency of free energy calculations in the amber molecular dynamics package. J Chem Theory Comput 9(9):4131–413910.1021/ct400340s ↗
38. Gasteiger E, Hoogland C, Gattiker A, Duvaud Se, Wilkins MR, Appel RD et al. (2005). Protein identification and analysis tools on the expasy server. In: Walker, J.M. (eds) The proteomics protocols handbook. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1385/1-59259-890-0:57110.1385/1-59259-890-0:571 ↗
39. Sormanni P, Aprile FA, Vendruscolo M (2015) The CamSol method of rational design of protein mutants with enhanced solubility. J Mol Biol 427(2):478–49010.1016/j.jmb.2014.09.026 ↗
40. van Teijlingen A, Smith MC, Tuttle T (2023) Short peptide self-assembly in the martini coarse-grain force field family. Acc Chem Res 56(6):644–65410.1021/acs.accounts.2c00810 ↗
41. Wassenaar TA, Ingólfsson HI, Bockmann RA, Tieleman DP, Marrink SJ (2015) Computational lipidomics with insane: a versatile tool for generating custom membranes for molecular simulations. J Chem Theory Comput 11(5):2144–215510.1021/acs.jctc.5b00209 ↗
42. Berendsen HJ, Postma Jv, Van Gunsteren WF, DiNola A, Haak JR (1984) Molecular dynamics with coupling to an external bath. J Chem Phys 81(8):3684–369010.1063/1.448118 ↗
43. Parrinello M, Rahman A (1981) Polymorphic transitions in single crystals: a new molecular dynamics method. J Appl Phys 52(12):7182–719010.1063/1.328693 ↗
44. Pan J, Mills TT, Tristram-Nagle S, Nagle JF (2008) Cholesterol perturbs lipid bilayers nonuniversally. Phys Rev Lett 100(19):19810310.1103/PhysRevLett.100.198103 ↗
45. Behrendt R, White P, Offer J (2016) Advances in Fmoc solid‐phase peptide synthesis. J Pept Sci 22(1):4–2710.1002/psc.2836 ↗
46. Eloy JO, de Claro Souza M, Petrilli R, Barcellos JPA, Lee RJ, Marchetti JM (2014) Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery. Colloids Surf B Biointerfaces 123:345–36310.1016/j.colsurfb.2014.09.029 ↗
47. Moreira J, Ishida T, Gaspar R, Allen T (2002) Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity. Pharm Res 19:265–26910.1023/A:1014434732752 ↗
48. Amao AO, Al-Otaibi B, Al-Ramadan K (2022) High-resolution X–ray diffraction datasets: carbonates. Data Brief 42:10820410.1016/j.dib.2022.108204 ↗
49. Tamm LK, Tatulian SA (1997) Infrared spectroscopy of proteins and peptides in lipid bilayers. Q Rev Biophys 30(4):365–42910.1017/S0033583597003375 ↗
50. Barth A, Zscherp C (2002) What vibrations tell about proteins. Q Rev Biophys 35(4):369–43010.1017/S0033583502003815 ↗
51. Hatakeyama H, Ito E, Akita H, Oishi M, Nagasaki Y, Futaki S et al (2009) A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J Control Release 139(2):127–13210.1016/j.jconrel.2009.06.008 ↗
52. Tartaglia GG, Vendruscolo M (2008) The zyggregator method for predicting protein aggregation propensities. Chem Soc Rev 37(7):1395–140110.1039/b706784b ↗
53. Rodriguez-Aller M, Guillarme D, Veuthey J-L, Gurny R (2015) Strategies for formulating and delivering poorly water-soluble drugs. J Drug Deliv Sci Technol 30:342–35110.1016/j.jddst.2015.05.009 ↗
54. Marrink SJ, Risselada HJ, Yefimov S, Tieleman DP, De Vries AH (2007) The MARTINI force field: coarse grained model for biomolecular simulations. J Phys Chem B 111(27):7812–782410.1021/jp071097f ↗
55. Monticelli L, Kandasamy SK, Periole X, Larson RG, Tieleman DP, Marrink S-J (2008) The MARTINI coarse-grained force field: extension to proteins. J Chem Theory Comput 4(5):819–83410.1021/ct700324x ↗
56. Róg T, Vattulainen I (2014) Cholesterol, sphingolipids, and glycolipids: what do we know about their role in raft-like membranes? Chem Phys Lipids 184:82–10410.1016/j.chemphyslip.2014.10.004 ↗
57. Belohorcova K, Davis JH, Woolf TB, Roux B (1997) Structure and dynamics of an amphiphilic peptide in a lipid bilayer: a molecular dynamics study. Biophys J 73(6):3039–305510.1016/S0006-3495(97)78332-2 ↗
58. Almeida PF (2014) Membrane-active peptides: binding, translocation, and flux in lipid vesicles. Biochimica Et Biophysica Acta (BBA)-Biomembranes 1838(9):2216–222710.1016/j.bbamem.2014.04.014 ↗
59. Yuan J, Yang Y, Dai K, Fakhrullin R, Li H, Zhou P et al (2025) Peptide coacervates: formation, mechanism, and biological applications. ACS Appl Mater Interfaces 17(19):27697–2771210.1021/acsami.5c04775 ↗
60. Drajkowska A, Molski A (2023) Aggregation and partitioning of amyloid peptide fragments in the presence of a lipid bilayer: a coarse grained molecular dynamics study. Biophys Chem 300:10705110.1016/j.bpc.2023.107051 ↗
61. Rastogi S, Shukla S, Kalaivani M, Singh GN (2019) Peptide-based therapeutics: quality specifications, regulatory considerations, and prospects. Drug Discov Today 24(1):148–16210.1016/j.drudis.2018.10.002 ↗
62. Castelletto V, Barnes RH, Karatzas KA, Edwards-Gayle CJ, Greco F, Hamley IW et al (2018) Restructuring of lipid membranes by an arginine-capped peptide bolaamphiphile. Langmuir 35(5):1302–131110.1021/acs.langmuir.8b01014 ↗
63. Schnorenberg MR (2020) Targeted delivery of therapeutic peptides using supramolecular nanomaterials to drug intracellular protein-protein interactions in cancer. Dissertation, The University of Chicago. https://doi.org/10.6082/UCHICAGO.272210.6082/UCHICAGO.2722 ↗
64. Nir S, Nieva JL (2000) Interactions of peptides with liposomes: pore formation and fusion. Prog Lipid Res 39(2):181–20610.1016/S0163-7827(00)00004-7 ↗
65. Sakai-Kato K, Yoshida K, Izutsu KI (2019) Effect of surface charge on the size-dependent cellular internalization of liposomes. Chem Phys Lipids 224:10472610.1016/j.chemphyslip.2019.01.004 ↗
66. Torchilin VP (2005) Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 4(2):145–16010.1038/nrd1632 ↗
67. Barth A (2007) Infrared spectroscopy of proteins. Biochimica et Biophysica Acta (BBA) 1767(9):1073–110110.1016/j.bbabio.2007.06.004 ↗
68. Arrondo JLR, Goni FM (1998) Infrared studies of protein-induced perturbation of lipids in lipoproteins and membranes. Chem Phys Lipids 96(1–2):53–6810.1016/S0009-3084(98)00080-2 ↗
69. Malyshka D, Pandiscia LA, Schweitzer-Stenner R (2014) Cardiolipin containing liposomes are fully ionized at physiological pH. An FT-IR study of phosphate group ionization. Vibr Spectrosc 75:86–9210.1016/j.vibspec.2014.10.003 ↗
70. Arouri A, Dathe M, Blume A (2009) Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes? Biochimica et Biophysica Acta (BBA) 1788(3):650–65910.1016/j.bbamem.2008.11.022 ↗
71. Sikorska E, Dawgul M, Greber K, Iłowska E, Pogorzelska A, Kamysz W (2014) Self-assembly and interactions of short antimicrobial cationic lipopeptides with membrane lipids: ITC, FTIR and molecular dynamics studies. Biochimica et Biophysica Acta (BBA) 1838(10):2625–263410.1016/j.bbamem.2014.06.016 ↗