Flash nanoprecipitation of hafnia nanoparticle computed tomography contrast agent
Source abstract
Abstract
Hafnium oxide (hafnia) nanoparticles have recently attracted attention for their application as computed tomography (CT) contrast agents due to their high X-ray attenuation and low cost. Here we employ flash nanoprecipitation (FNP) to formulate hafnia nanoclusters (HNCs) consisting of a core of precipitated individual hafnia nanoparticles and polylactic acid homopolymer and an outer coating of the block copolymer polylactic acid-b-polyethylene glycol (PLA-b-PEG). The HNCs can be produced with controlled hydrodynamic size in the range of 100–300 nm using a simple 3D-printed FNP mixer. The CT performance of the HNCs was evaluated in a pre-clinical small animal scanner and in a clinical scanner. In both systems the HNCs displayed ~1.5× greater contrast compared to the commercial iodinated molecular contrast agent Omnipaque used clinically.
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Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes · Catalytic Processes in Materials Science
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
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