Gold-capsuled polymeric nanomedicine for synergistic breast cancer photo-chemotherapy
Source abstract
Abstract
Photo-chemotherapy is a potent anticancer therapeutic approach. Herein, we designed a gold-capsulated lapatinib nanomedicine for breast cancer treatment. The biodegradable PLGA (poly (lactic-co-glycolic acid)) nanoparticles were surface coated with glycol chitosan followed by adsorption and reduction of gold seeds on the surface to form nanocapsule. These multifunctional nanomaterials exhibited significant absorbance (600–900 nm) in the near-infrared region and had a porous surface that facilitated controlled diffusion of the encapsulated anticancer drug, lapatinib. Further, the gold-coated PLGA lapatinib nanocapsule showed synergistic effect of combined chemo-photothermal therapy with > 80% cytotoxicity. Moreover, these nanomaterials were found to be non-hemolytic and biocompatible. The biodistribution of the nanocapsule in Balb/c mice revealed higher Au content in the liver followed by spleen with no significant change in body weight and abnormal clinical signs. Hence, gold-capsuled polymeric nanomedicine could be a promising therapeutic agent. Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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