Facile synthesis of Fe3O4 nanoparticles at room temperature coated with meso-2,3-dimercaptosuccinic acid for improved biocompatibility
Source abstract
Abstract
Superparamagnetic magnetite Fe3O4 nanoparticles (NPs) were synthesized by the coprecipitation method and stabilized with meso-2,3-dimercaptosuccinic acid (DMSA) under ambient conditions and a nitrogen atmosphere at room temperature in one simple step. The X-ray diffraction (XRD) analysis of Fe3O4 NPs confirmed their cubic spinel structure with high crystallinity for both samples prepared with or without nitrogen atmosphere. The scanning electron microscopy analysis showed an average particle size of 15.0 ± 3 nm and 23.0 ± 5 nm in the absence and presence of nitrogen, respectively. Our particles have shown excellent magnetic properties with a high saturation magnetization (55 emu/g), low remanence (3.0 emu/g), and low coercivity (43 Oe). The method of synthesis proposed here offers excellent reproducibility of superparamagnetic NPs with narrow size distribution and low aggregation despite the simplicity of its preparation. The dose–response curves of the colorimetric assay MTT carried out in HCT 116 cell cultures in a range from 30 to 250 μg/mL reveal that magnetic nanoparticles coated with DMSA significantly improve their biocompatibility for applications like magnetic hyperthermia, magnetic resonance imaging, or biosensing. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Iron oxide chemistry and applications · Characterization and Applications of Magnetic Nanoparticles
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (26)
Show source-provided references
1. Fratila RM, de la Fuente JM (2018) Introduction to hyperthermia. Nanomater Magn Opt Hyperth Appl. https://doi.org/10.1016/B978-0-12-813928-8.09997-X10.1016/B978-0-12-813928-8.09997-X ↗
2. Wu W, Wu Z, Yu T, Jiang C, Kim WS (2015) Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater. https://doi.org/10.1088/1468-6996/16/2/02350110.1088/1468-6996/16/2/023501 ↗
3. Ali A, Shah T, Ullah R, Zhou P, Guo M, Ovais M, Tan Z, Rui Y (2021) Review on recent progress in magnetic nanoparticles: synthesis, characterization, and diverse applications. Front Chem 9:629054. https://doi.org/10.3389/fchem.2021.62905410.3389/fchem.2021.629054 ↗
4. Martins PM, Lima AC, Ribeiro S, Lanceros-Mendez S, Martins P (2021) Magnetic nanoparticles for biomedical applications: from the soul of the earth to the deep history of ourselves. ACS Appl Bio Mater 4:5839–5870. https://doi.org/10.1021/acsabm.1c0044010.1021/acsabm.1c00440 ↗
5. Hedayatnasab Z, Abnisa F, Daud WMAW (2017) Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application. Mater Des 123:174–196. https://doi.org/10.1016/j.matdes.2017.03.03610.1016/j.matdes.2017.03.036 ↗
6. Gomes IP, Duarte JA, Maia ALC, Rubello D, Townsend DM, de Barros ALB, Leite EA (2019) Thermosensitive nanosystems associated with hyperthermia for cancer treatment. Pharmaceuticals. https://doi.org/10.3390/ph1204017110.3390/ph12040171 ↗
7. Liu X, Zhang Y, Wang Y, Zhu W, Li G, Ma X, Zhang Y, Chen S, Tiwari S, Shi K, Zhang S, Fan HM, Zhao YX, Liang XJ (2020) Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy. Theranostics 10:3793–3815. https://doi.org/10.7150/thno.4080510.7150/thno.40805 ↗
8. Bronstein LM, Huang X, Retrum J, Schmucker A, Pink M, Stein BD, Dragnea B (2007) Influence of iron oleate complex structure on iron oxide nanoparticle formation. Chem Mater 19:3624–3632. https://doi.org/10.1021/cm062948j10.1021/cm062948j ↗
9. Martins ES, Espindola A, Britos TN, Chagas C, Barbosa E, Castro CE, Fonseca FLA, Haddad PS (2021) Potential use of DMSA-containing iron oxide nanoparticles as magnetic vehicles against the COVID-19 disease. Chemistry Select 6:7931–7935. https://doi.org/10.1002/slct.20210190010.1002/slct.202101900 ↗
10. Chen ZP, Zhang Y, Zhang S, Xia JG, Liu JW, Xu K, Gu N (2008) Preparation and characterization of water-soluble monodisperse magnetic iron oxide nanoparticles via surface double-exchange with DMSA. Colloids Surfaces A Physicochem Eng Asp 316:210–216. https://doi.org/10.1016/j.colsurfa.2007.09.01710.1016/j.colsurfa.2007.09.017 ↗
11. Cheraghipour E, Javadpour S, Mehdizadeh AR (2012) Citrate capped superparamagnetic iron oxide nanoparticles used for hyperthermia therapy. J Biomed Sci Eng 05:715–719. https://doi.org/10.4236/jbise.2012.51208910.4236/jbise.2012.512089 ↗
12. Kosnett MJ (2016) Succimer (DMSA). In: Brent, J., Burkhart, K., Dargan, P., Hatten, B., Megarbane, B., Palmer, R. (eds) Critical Care Toxicology. Springer Cham. https://doi.org/10.1007/978-3-319-20790-2_20-110.1007/978-3-319-20790-2_20-1 ↗
13. Silva LHA, da Silva JR, Ferreira GA, Silva RC, Lima ECD, Azevedo RB, Oliveira DM (2016) Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications. Nanobiotechnol. https://doi.org/10.1186/s12951-016-0213-x10.1186/s12951-016-0213-x ↗
14. Zhang S, Bian Z, Gu C, Zhang Y, He S, Gu N, Zhang J (2007) Preparation of anti-human cardiac troponin I immuno-magnetic nanoparticles and biological activity assays. Colloids Surf B 55:143–148. https://doi.org/10.1016/j.colsurfb.2006.11.04110.1016/j.colsurfb.2006.11.041 ↗
15. Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media Magnetics. IEEE Trans 17:1247–1248. https://doi.org/10.1109/TMAG.1981.106118810.1109/TMAG.1981.1061188 ↗
16. Hyeon T, Lee LL, Park J, Chung Y, Na HB (2001) Synthesis of highly crystalline and monodisperse maghemite nano-crystallites without a size-selection process. J Am Chem Soc 123:12798–12801. https://doi.org/10.1021/ja016812s10.1021/ja016812s ↗
17. Sun S, Zeng H (2002) Size-controlled synthesis of magnetite nanoparticles. J Am Chem Soc 124:8204–8205. https://doi.org/10.1021/ja026501x10.1021/ja026501x ↗
18. Senem C, Özlem DC, Le DT, Mehmet AO, Nguyen TKT (2021) DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents. Nanomedicine 16:925–941. https://doi.org/10.2217/nnm-2020-046710.2217/nnm-2020-0467 ↗
19. Ullrich A, Rahman MM, Azhar A et al (2022) Synthesis of iron oxide nanoparticles by decomposition of iron-oleate: influence of the heating rate on the particle size. J Nanopart Res. https://doi.org/10.1007/s11051-022-05554-910.1007/s11051-022-05554-9 ↗
20. Dheyab MA, Azlan AA, Mahmood SJ, Osama AN, Pegah MK, Baharak M (2020) Simple rapid stabilization method through citric acid modification for magnetite nanoparticles. Sci Rep. https://doi.org/10.1038/s41598-020-67869-810.1038/s41598-020-67869-8 ↗
21. Patel U, Chauhan K and Gupte S (2018) Synthesis, characterization and application of lipase-conjugated citric acid-coated magnetic nanoparticles for ester synthesis using waste frying oil. 3 Biotech. https://doi.org/10.1007/s13205-018-1228-910.1007/s13205-018-1228-9 ↗
22. Li L, Mak KY, Leung CW, Chan KY, Chan WK, Zhong W, Pong PWT (2013) Effect of synthesis conditions on the properties of citric-acid coated iron oxide nanoparticles. Microelectron Eng 110:329–334. https://doi.org/10.1016/j.mee.2013.02.04510.1016/j.mee.2013.02.045 ↗
23. Hadadian Y, Masoomi H, Dinari A, Ryu C, Hwang S, Kim S, Cho BK, Young Lee J, Yoon J (2022) From low to high saturation magnetization in magnetite nanoparticles: the crucial role of the molar ratios between the chemicals. ACS Omega 7:15996–16012. https://doi.org/10.1021/acsomega.2c0113610.1021/acsomega.2c01136 ↗
24. Nedelkoski Z, Kepaptsoglou D, Lari L, Tianlong W, Booth RA, Oberdick SD, Galindo PL, Ramasse QM, Evans RFL, Majetich S, Lazarov VK (2017) Origin of reduced magnetization and domain formation in small magnetite nanoparticles. Sci Rep 7:45997. https://doi.org/10.1038/srep4599710.1038/srep45997 ↗
25. Park J, Lee E, Hwang NM, Kang M, Kim SC, Hwang Y, Park JG, Noh HJ, Kim JY, Park JH, Hyeon T (2005) One-nanometer-scale size-controlled synthesis of monodisperse magnetic iron oxide nanoparticles. Angew Chem Int Ed 44:2872–2877. https://doi.org/10.1002/anie.20046166510.1002/anie.200461665 ↗
26. Çitoğlu S, Coşkun ÖD, Tung LD, Onur MA, Kim Thanh NT (2021) DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents. Nanomedicine 16:925–941. https://doi.org/10.2217/nnm-2020-046710.2217/nnm-2020-0467 ↗