Enhancement of radiation response of breast cancer cells through the incorporation of Bi2S3 nanorods
Source abstract
Abstract
The aim of this work was to develop nanomaterials that can be used as sensitizers in radiotherapy treatment. The synthesis of bismuth sulfide (Bi2S3) particles with nanometer size by the hot injection method was studied as well as their behavior when coated with a biocompatible agent. The hot injection method allowed us to synthesize Bi2S3 nanorods measuring in average 4.2 ± 1.4 nm in width and 27.5 ± 16.3 nm in length. Moreover, to improve their biocompatibility, these nanorods were coated with polyvinylpyrrolidone with the purpose of studying the behavior of nanorods in the bloodstream. The results indicated that the suspensions were more stable when the media had protein components which may facilitate the blood circulation of the particles. The toxicity of the nanorods and their radiosensitization potential were evaluated and determined in breast cancer cells (MCF7). These results show that the synthesized nanorods did not evidence cytotoxicity up to a concentration of 2500 μg/mL, over 72 h of incubation. On the other hand, the sensitivity of MCF7 cells with and without nanorods in the culture medium, afterward irradiating them with a dose of 2 Gy 60Co gamma radiation source, showed a 38% increase in cell death when compared to cells that were only irradiated. Our results show that Bi2S3 nanorods are very promising as anticancer agents improving the efficiency of radiotherapy.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Radiotherapy Techniques · Radiation Therapy and Dosimetry · Advances in Oncology and Radiotherapy
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Baumann M et al (2016) Radiation oncology in the era of precision medicine. Nat Rev Cancer 16(4):234–249. https://doi.org/10.1038/nrc.2016.1810.1038/nrc.2016.18 ↗
2. Hall EJ, Giaccia AJ (2012) Radiobiology for the radiologist, 7th edn. Lippincott Williams & Wilkins, Philadelphia, USA
3. Halliwell B, Aruoma OL (1991) DNA damage by oxygen-derived species. FEBS Lett 281:9–19. https://doi.org/10.1016/0014-5793(91)80347-610.1016/0014-5793(91)80347-6 ↗
4. Christensen DM, Iddins CJ, Sugarman SL (2014) Ionizing radiation injuries and illnesses. Emerg Med Clin North Am 32(1):245–265. https://doi.org/10.1016/j.emc.2013.10.00210.1016/j.emc.2013.10.002 ↗
5. Atun R et al (2015) Expanding global access to radiotherapy. Lancet Oncol 16(10):1153–1186. https://doi.org/10.1016/S1470-2045(15)00222-310.1016/S1470-2045(15)00222-3 ↗
6. Joiner M, van der Kogel A (2009) Basic clinical radiobiology, 4th edn. Hodder Arnold, Great Britain10.1201/b15450 ↗
7. Wang H, Mu X, He H, Zhang XD (2018) Cancer radiosensitizers. Trends Pharmacol Sci 39(1):24–48. https://doi.org/10.1016/j.tips.2017.11.00310.1016/j.tips.2017.11.003 ↗
8. Kwatra D, Venugopal A, Anant S (2013) Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer. Transl Cancer Res 2(4):330–342. https://doi.org/10.21037/155010.21037/1550 ↗
9. Retif P et al (2015) Nanoparticles for radiation therapy enhancement: the key parameters. Theranostics 5(9):1030–1044. https://doi.org/10.7150/thno.1164210.7150/thno.11642 ↗
10. Jeremic B, Aguerri AR, Filipovic N (2013) Radiosensitization by gold nanoparticles. Clin Transl Oncol 15(8):593–601. https://doi.org/10.1007/s12094-013-1003-710.1007/s12094-013-1003-7 ↗
11. Her S, Jaffray DA, Allen C (2017) Gold nanoparticles for applications in cancer radiotherapy: mechanisms and recent advancements. Adv Drug Deliv Rev 109:84–101. https://doi.org/10.1016/j.addr.2015.12.01210.1016/j.addr.2015.12.012 ↗
12. Mirjolet C et al (2013) The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: a proof-of-concept. Radiother Oncol 108(1):136–142. https://doi.org/10.1016/j.radonc.2013.04.00410.1016/j.radonc.2013.04.004 ↗
13. Swanner J et al (2015) Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Int J Nanomedicine 10:3937–3953. https://doi.org/10.2147/IJN.S8034910.2147/IJN.S80349 ↗
14. Maggiorella L et al (2012) Nanoscale radiotherapy with hafnium oxide nanoparticles. Futur Oncol 8(9):1167–1181. https://doi.org/10.2217/fon.12.9610.2217/fon.12.96 ↗
15. Klein S, Sommer A, Distel LVR, Neuhuber W, Kryschi C (2012) Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation. Biochem Biophys Res Commun 425(2):393–397. https://doi.org/10.1016/j.bbrc.2012.07.10810.1016/j.bbrc.2012.07.108 ↗
16. Juzenas P et al (2008) Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv Drug Deliv Rev 60(15):1600–1614. https://doi.org/10.1016/j.addr.2008.08.00410.1016/j.addr.2008.08.004 ↗
17. Xie J, Gong L, Zhu S, Yong Y, Gu Z, Zhao Y (2018) Emerging strategies of nanomaterial-mediated tumor radiosensitization. Cancer Ther 1802244:1–25. https://doi.org/10.1002/adma.20180224410.1002/adma.201802244 ↗
18. Wu T, Zhou X, Zhang H, Zhong X (2010) Bi2S3 nanostructures: a new photocatalyst. Nano Res 3(5):379–386. https://doi.org/10.1007/s12274-010-1042-010.1007/s12274-010-1042-0 ↗
19. Wang D et al (2009) Bi2S3 nanotubes: facile synthesis and growth mechanism. Nano Res 2:130–134. https://doi.org/10.1007/s12274-009-9010-210.1007/s12274-009-9010-2 ↗
20. Yu Y, Jin CH, Wang RH, Chen Q, Peng L (2005) High-quality ultralong Bi2S3 nanowires: structure, growth, and properties. J Phys Chem B 109:18772–1877610.1021/jp051294j ↗
21. Nambiar S, Osei EK, Yeow JTW (2015) Bismuth sulfide nanoflowers for detection of X-rays in the mammographic energy range. Sci Rep 5(9440):1–8. https://doi.org/10.1038/srep0944010.1038/srep09440 ↗
22. Zhang H, Huang J, Zhou X, Zhong X (2011) Single-crystal Bi2S3 nanosheets growing via attachment-recrystallization of nanorods. Inorg Chem 50(16):7729–7734. https://doi.org/10.1021/ic201332n10.1021/ic201332n ↗
23. Alqathami M, Blencowe A, Geso M, Ibbott G (2016) Quantitative 3D determination of radiosensitization by bismuth-based nanoparticles. J Biomed Nanotechnol 12(3):464–471. https://doi.org/10.1166/jbn.2016.218310.1166/jbn.2016.2183 ↗
24. Algethami M et al (2015) Radiation dose enhancement using Bi2S3 nanoparticles in cultured mouse PC3 prostate and B16 melanoma cells. Nano World J 1(3):97–102. https://doi.org/10.17756/nwj.2015-01310.17756/nwj.2015-013 ↗
25. Rabin O, Perez JM, Grimm J, Wojtkiewicz G, Weissleder R (2006a) An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater 5(2):118–122. https://doi.org/10.1038/nmat157110.1038/nmat1571 ↗
26. Algethami M, Blencowe A, Feltis B, Geso M (2017) Bismuth sulfide nanoparticles as a complement to traditional iodinated contrast agents at various X-ray computed tomography tube potentials. J Nanomater Mol Nanotechnol 06(04):2–10. https://doi.org/10.4172/2324-8777.100022210.4172/2324-8777.1000222 ↗
27. Azizi S, Nosrati H, Sharafi A, Danafar H (2020) Preparation of bismuth sulfide nanoparticles as targeted biocompatible nano-radiosensitizer and carrier of methotrexate. Appl Organomet Chem 34(1):1–10. https://doi.org/10.1002/aoc.525110.1002/aoc.5251 ↗
28. Nosrati H, Charmi J, Salehiabar M, Abhari F, Danafar H (2019) Tumor targeted albumin coated bismuth sulfide nanoparticles (Bi2S3) as radiosensitizers and carriers of curcumin for enhanced chemoradiation therapy. ACS Biomater Sci Eng 5(9):4416–4424. https://doi.org/10.1021/acsbiomaterials.9b0048910.1021/acsbiomaterials.9b00489 ↗
29. Yu H et al (2019) Effective radiotherapy in tumor assisted by ganoderma lucidum polysaccharide-conjugated bismuth sulfide nanoparticles through radiosensitization and dendritic cell activation. ACS Appl Mater Interfaces 11(31):27536–27547. https://doi.org/10.1021/acsami.9b0780410.1021/acsami.9b07804 ↗
30. Wang X et al (2019) Enhanced generation of non-oxygen dependent free radicals by Schottky-type heterostructures of Au-Bi2S3 nanoparticles via X-ray-induced catalytic reaction for radiosensitization. ACS Nano 13(5):5947–5958. https://doi.org/10.1021/acsnano.9b0181810.1021/acsnano.9b01818 ↗
31. Ibáñez M et al (2011) Growth kinetics of asymmetric Bi2S3 nanocrystals: size distribution. J Phys Chem C 115:7947–7955. https://doi.org/10.1021/jp200290410.1021/jp2002904 ↗
32. Schindelin J et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676–682. https://doi.org/10.1038/nmeth.201910.1038/nmeth.2019 ↗
33. RStudio, RStudio: integrated development environment for R. July 19th, 2018, Boston, MA., [Online]. https://doi.org/10.1002/jwmg.232.10.1002/jwmg.232 ↗
34. Han SK, Gu C, Gong M, Yu SH (2015a) A trialkylphosphine-driven chemical transformation route to Ag- and Bi-based chalcogenides. J Am Chem Soc 137(16):5390–5396. https://doi.org/10.1021/jacs.5b0004110.1021/jacs.5b00041 ↗
35. Jin J, He T (2017) Facile synthesis of Bi2S3 nanoribbons for photocatalytic reduction of CO2 into CH3OH. Appl Surf Sci 394:364–370. https://doi.org/10.1016/j.apsusc.2016.10.11810.1016/j.apsusc.2016.10.118 ↗
36. Konstantatos G, Levina L, Tang J, Sargent EH (2008) Sensitive solution-processed Bi2S3 nanocrystalline photodetectors. Nano Lett 8(11):4002–4006. https://doi.org/10.1021/nl802600z10.1021/nl802600z ↗
37. Ai K, Liu Y, Liu J, Yuan Q, He Y, Lu L (2011) Large-scale synthesis of Bi2S3 nanodots as a contrast agent for in vivo X-ray computed tomography imaging. Adv Mater 23(42):4886–4891. https://doi.org/10.1002/adma.20110328910.1002/adma.201103289 ↗
38. Han P, Mihi A, Ferre-Borrull J, Pallarés J, Marsal LF (2015b) Interplay between morphology, optical properties, and electronic structure of solution-processed Bi2S3 colloidal nanocrystals. J Phys Chem C 119(19):10693–10699. https://doi.org/10.1021/acs.jpcc.5b0130510.1021/acs.jpcc.5b01305 ↗
39. D. J. Riley, J. P. Waggett, and K. G. Upul Wijayantha, 2004 Colloidal bismuth sulfide nanoparticles: a photoelectrochemical study of the relationship between bandgap and particle size, J. Mater. Chem., pp. 704–708, https://doi.org/10.1039/b311517h.10.1039/b311517h ↗
40. Malakooti R, Cademartiri L, Akçakir Y, Petrov S, Migliori A, Ozin GA (2006) Shape-controlled Bi2S3 nanocrystals and their plasma polymerization into flexible films. Adv Mater 18(16):2189–2194. https://doi.org/10.1002/adma.20060046010.1002/adma.200600460 ↗
41. Huang HH et al (2013a) Synthesis and characterization of Bi2S3 composite nanoparticles with high X-ray absorption. Mater Res Bull 48(10):3800–3804. https://doi.org/10.1016/j.materresbull.2013.05.09110.1016/j.materresbull.2013.05.091 ↗
42. Huang J, Zhang H, Zhou X, Zhong X (2013b) Dimensionality-dependent performance of nanostructured bismuth sulfide in photodegradation of organic dyes. Mater Chem Phys 138(2–3):755–761. https://doi.org/10.1016/j.matchemphys.2012.12.05310.1016/j.matchemphys.2012.12.053 ↗
43. Rabin O, Perez JM, Grimm J, Wojtkiewicz G, Weissleder R (2006b) An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater 5:118–122. https://doi.org/10.1038/nmat157110.1038/nmat1571 ↗
44. Yao MH et al (2014) Multifunctional Bi2S3/PLGA nanocapsule for combined HIFU/radiation therapy. Biomaterials 35(28):8197–8205. https://doi.org/10.1016/j.biomaterials.2014.06.01010.1016/j.biomaterials.2014.06.010 ↗
45. Ma M et al (2015) Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. Biomaterials 37:447–455. https://doi.org/10.1016/j.biomaterials.2014.10.00110.1016/j.biomaterials.2014.10.001 ↗
46. Wang Y et al (2016) BSA-mediated synthesis of bismuth sulfide nanotheranostic agents for tumor multimodal imaging and thermoradiotherapy. Adv Funct Mater 26(29):5335–5344. https://doi.org/10.1002/adfm.20160134110.1002/adfm.201601341 ↗
47. Thongtem T, Phuruangrat A, Wannapop S, Thongtem S (2010) Characterization of Bi2S3 with different morphologies synthesized using microwave radiation. Mater Lett 64(2):122–124. https://doi.org/10.1016/j.matlet.2009.10.00610.1016/j.matlet.2009.10.006 ↗
48. Cheng X et al (2017) Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment. Theranostics 7(17):4087–4098. https://doi.org/10.7150/thno.2054810.7150/thno.20548 ↗
49. Chen J et al (2014) In vitro and in vivo CT imaging using bismuth sulfide modified with a highly biocompatible Pluronic F127. Nanotechnology 25(29):295103. https://doi.org/10.1088/0957-4484/25/29/29510310.1088/0957-4484/25/29/295103 ↗
50. Zou Q, Hou F, Wang H, Liao Y, Wang Q, Yang Y (2019) Microfluidic one-step preparation of alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles and their photothermal effect. Eur Polym J 115:282–289. https://doi.org/10.1016/j.eurpolymj.2019.03.04010.1016/j.eurpolymj.2019.03.040 ↗