Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach
Source abstract
Abstract
The luminescent lanthanide-doped nanoparticles have gathered considerable attention in many fields especially in biomedicine. In this work, the lanthanum fluoride-doped terbium nanoparticles (LaF3:Tb3+ NPs) via simple chemical precipitation method has been synthesized and functionalized with polyethylene glycol. The size and the shape of the nanoparticles are confirmed using X-ray diffraction and transmission electron microscopy. The conjugation of 5-Fluorouracil (5-FU) and thus synthesized nanoparticles (NPs) were confirmed using various spectroscopic methods such as UV–Visible spectroscopy, fluorescence steady state, and excited state spectroscopy studies. The enhancement in fluorescence emission (λ = 543 nm) of drug-conjugated nanoparticles confirms the Vander Waals force of attraction due to F–F bonding between the drug and the nanoparticles. Further, the effects of 5FU-NPs in carrier protein were investigated using bovine serum albumin as a protein model. The 5FU–LaF3:Tb3+ nanoparticles binding is illustrated with binding constant and number of binding sites. The structural change of bovine serum albumin has been studied using circular dichroism and Fourier transform infrared spectroscopy analysis.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Protein Interaction Studies and Fluorescence Analysis · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Abdi K, Nafisi Sh, Manouchehri F, Bonsaii M, Khalaj A (2012) Interaction of 5-Fluorouracil and its derivatives with bovine serum albumin. J Photochem Photobiol 107:20–26. doi: 10.1016/j.jphotobiol.2011.11.00410.1016/j.jphotobiol.2011.11.004 ↗
2. Amir M, Seyed AS, Ebrahim VF (2008) 5-Fluorouracil-loaded BSA nanoparticles: formulation optimization and in vitro release study. AAPS Pharm SciTech 9(4):1092–1096. doi: 10.1208/s12249-008-9146-510.1208/s12249-008-9146-5 ↗
3. Ansari AA, Singh N, Singh SP (2008) Optical properties of pyridine functionalized TbF3 nanoparticles. J Nanopart Res 10(4):703–707. doi: 10.1007/s11051-007-9297-410.1007/s11051-007-9297-4 ↗
4. Bakkialakshmi S, Chandrakala D (2011) A study on the interaction of 5-Fluorouracil with human serum albumin using fluorescence quenching method. J Pharm Sci Res 3(7):1326–1329
5. Barbero N, Barni E, Barolo C, Quagliotto P, Viscardi G, Napione l, Pavan S, Bussolino F (2009) A study of the interaction between fluorescein sodium salt and bovine serum albumin by steady-state fluorescence. Dyes Pigments 80:307–313. doi: 10.1016/j.dyepig.2008.08.00610.1016/j.dyepig.2008.08.006 ↗
6. Bardhan R, Grady NK, Cole JR, Joshi A, Halas NJ (2009) Fluorescence enhancement by Au nanostructures: nanoshells and nanorods. ACS Nano 3(3):744–752. doi: 10.1021/nn900001q10.1021/nn900001q ↗
7. Bi S, Sun Y, Qiao C, Zhang H, Liu C (2009) Binding of several anti-tumor drugs to bovine serum albumin: Fluorescence study. J Lumin 129(5):541–547. doi: 10.1016/j.jlumin.2008.12.01010.1016/j.jlumin.2008.12.010 ↗
8. Carlo B, Giorgio A, Gloria UB, Lorenzo DB, Piero S (1995) The binding of 5-Fluorouracil to native and modified human serum albumin: UV, CD, and 1H and 19F NMR investigation. J Pharm Biomed Anal 13:1087–109310.1016/0731-7085(95)01548-Y ↗
9. Chai R, Lian H, Yang P, Fan Y, Hou Z, Kang X, Liu J (2009) In situ preparation and luminescent properties of LaPO4:Ce3+, Tb3+nanoparticles and transparent LaPO4:Ce3+, Tb3+/PMMA nanocomposites. J Colloid Interface Sci 336:46–50. doi: 10.1016/j.jcis.2009.03.07910.1016/j.jcis.2009.03.079 ↗
10. Chander H, Chawla S (2008) Time resolved spectroscopic studies on some nanophosphors. Bull Mater Sci 31(3):401–40710.1007/s12034-008-0063-8 ↗
11. Chaudhary A, Gupta A, Khan S, Nandi CK (2014) Morphological effect of gold nanoparticles on the adsorption of bovine serum albumin. Phys Chem Chem Phys 16:20471–20482. doi: 10.1039/c4cp01515k10.1039/C4CP01515K ↗
12. Chinnathambi S, Velmurugan D, Hanagata N, Aruna P, Ganesan S (2014) Investigations on the interactions of 5-Fluorouracil with bovine serum albumin: optical spectroscopic and molecular modelling studies. J Lumin 151:1–10. doi: 10.1016/j.jlumin.2014.01.06310.1016/j.jlumin.2014.01.063 ↗
13. Dai Q, Wang Y, Li X, Zhang Y, Pellegrino DJ, Zhao M, Zou B, Seo JT, Wang Y, Yu W (2009) Size-dependent composition and molar extinction coefficient of PbSe semiconductor nanoparticles. ACS Nano 3(6):1518–1524. doi: 10.1021/nn900161610.1021/nn9001616 ↗
14. Dai Y, Yang D, Ma P, Kang X, Zhan X, Li C, Hou Z, Cheng Z, Lin J (2012) Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer. Biomaterials 33:8704–8713. doi: 10.1016/j.biomaterials.2012.08.02910.1016/j.biomaterials.2012.08.029 ↗
15. Gao D, Zhang X, Zhang J (2014) The effects of structural characterization on the luminescence of Eu3+-doped fluoride nano/microcrystals. Cryst Eng Commun 16:11115–1112110.1039/C4CE01726A ↗
16. Gaurkhede SG, Khandpekar MM, Pati SP, Singh AT (2013) Synthesis of hexagonal LaF3:ND3+, SM3+ nanocrystals and studies of NLO properties. Nanosystems 4(2):241–246
17. Gipson K, Kucera C, Stadther D, Stevens K, Ballato J, Brown P (2011) The influence of synthesis parameters on particle size and photoluminescence characteristics of ligand capped Tb3+:LaF3. Polymers 3(4):2039–2052. doi: 10.3390/polym304203910.3390/polym3042039 ↗
18. Gui R, Wan A, Jin H (2013) Facile synthesis of quantum dots/mesoporous silica/quantum dots core/shell/shell hybrid microspheres for ratiometric fluorescence detection of 5-Fluorouracil in human serum. Analyst 138:5956–5964. doi: 10.1039/c3an01089a10.1039/c3an01089a ↗
19. Hanwen S, Yuanyuan W, Pan H, Yanli Z, Lv Yunkai (2012) Characterization of interaction between antitumor drug 5-Fluorouracil and human serum albumin by affinity capillary electrophoresis. Asian J Pharm Sci 7(1):75–79
20. Hao S, Chen G, Yang C (2013) Sensing using rare-earth-doped upconversion nano-particles. Theranostics 3(5):331–345. doi: 10.7150/thno.530510.7150/thno.5305 ↗
21. Janib SM, Moses AS, Andrew JM (2010) Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev 62:1052–1063. doi: 10.1016/j.addr.2010.08.00410.1016/j.addr.2010.08.004 ↗
22. Jing K, Guo X, Diao X, Wu Q, Jiang Y, Sun Y, Pan X, Zhou N, Zhu Y (2015) Synthesis and characterization of dipicolinate sensitized LaF3:Tb3+ nanoparticles and their interaction with bovine serum albumin. J Lumin 157:184–192. doi: 10.1016/j.jlumin.2014.08.06110.1016/j.jlumin.2014.08.061 ↗
23. Lakowicz JR (1999) Principles of fluorescence spectroscopy. Plenum Press, New York 27810.1007/978-1-4757-3061-6 ↗
24. Lekha NK, Sankar J, Asha NS, Vinod KGS (2011) Biological evaluation of 5-Fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. Int J Nanomed 6:1685–1697. doi: 10.2147/IJN.S20165
25. Li Y, He W, Liu J, Sheng F, Hu Z, Chen X (2005) Binding of the bioactive component jatrorrhizine to human serum albumin. Biochem Biophys Acta 1722:15–21. doi: 10.1016/j.bbagen.2004.11.00610.1016/j.bbagen.2004.11.006 ↗
26. Li C, Ma P, Yang P, Xu Z, Li G, Yang D, Penga C, Lin J (2011) Fine structural and morphological control of rare earth fluorides REF3 (RE ¼ La–Lu, Y) nano/microcrystals: microwave-assisted ionic liquid synthesis, magnetic and luminescent properties. Cryst Eng Commun 13:1003–1013. doi: 10.1039/c0ce00186d10.1039/C0CE00186D ↗
27. Liu Y, Chen W, Wang S, Joly AG, Westcott S, Woo BK (2008a) X-ray luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ water-soluble nanoparticles. J Appl Phys 103(6):063105. doi: 10.1063/1.289014810.1063/1.2890148 ↗
28. Liu Y, Chen W, Wang S, Joly AG (2008b) Investigation of water-soluble X-ray luminescence nanoparticles for photodynamic activation. Appl Phys Lett 92:043901. doi: 10.1063/1.283570110.1063/1.2835701 ↗
29. Louis C, Bazzi R, Marquette CA, Bridot J, Roux S, Ledoux G, Mercier B, Blum L, Perriat P, Tillement O (2005) Nanosized hybrid particles with double luminescence for biological labeling. Chem Mater 17(7):1673–1682. doi: 10.1021/cm048016210.1021/cm0480162 ↗
30. Mandal G, Bardhan M, Ganguly T (2010) Interaction of bovine serum albumin and albumin-gold nanoconjugates with l-aspartic acid. A spectroscopic approach. Colloid Surf B 81:178–184. doi: 10.1016/j.colsurfb.2010.07.00210.1016/j.colsurfb.2010.07.002 ↗
31. Manna A, Chakravorti S (2013) Role of block copolymer-micelle nanocomposites in dye–bovine serum albumin binding: a combined experimental and molecular docking study. Mol Bio Syst 9:246–257. doi: 10.1039/C2MB25368B
32. Ming RC, Qing L, Tao W, Bing H, Jiang H, Hou XC, Feng XY, Wei W, Hong ZX, Tao Y, Bing BZ (2012) Galactosylated chitosan/5-Fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects. J Gastroenterol 18(42):6076–6087. doi: 10.3748/wjg.v18.i42.6076
33. Pramanik S, Banerjee P, Sarkar A, Bhattacharya SC (2008) Size-dependent interaction of gold nanoparticles with transport protein: a spectroscopic study. J Lumin 128:1969–1974. doi: 10.1016/j.jlumin.2008.06.00810.1016/j.jlumin.2008.06.008 ↗
34. Qiao J, Fabian M, Seema A (2011) Biocompatible drug delivery system for photo-triggered controlled release of 5-Fluorouracil. Biomacromolecules 12:3684–3691. doi: 10.1021/bm200912510.1021/bm2009125 ↗
35. Seda AR, Mehlika P (2012) 5-Fluorouracil encapsulated chitosan nanoparticles for pH-stimulated drug delivery: evaluation of controlled release kinetics. J Nanomater 1–10:42. doi: 10.1155/2012/313961
36. Selvaraj V, Alagar M (2007) Analytical detection and biological assay of antileukemic drug 5-Fluorouracil using gold nanoparticles as probe. Int J Pharm 337:275–281. doi: 10.1016/j.ijpharm.2006.12.02710.1016/j.ijpharm.2006.12.027 ↗
37. Song RQ, Colfen’k H (2010) Mesocrystals: ordered nanoparticle superstructures. Adv Mater 22(12):1301–1330. doi: 10.1002/adma.20090136510.1002/adma.200901365 ↗
38. Stephanos JJ, Farina SA, Addison AW (1996) Iron ligand recognition by monomeric hemoglobins. Biochim Biophys Act 1295:209–22110.1016/0167-4838(96)00041-6 ↗
39. Stoudam JW, Van Veggel FCJM (2002) Near-infrared emission of redispersible Er3+, Nd3+, and Ho3+ doped LaF3 nanoparticles. Nano Lett 2:733–737. doi: 10.1021/nl025562q10.1021/nl025562q ↗
40. Sulkowska A, Rownicka J, Bojko B, Sulkowski W (2003) Interaction of anticancer drugs with human and bovine serum albumin. J Mol Struct 651:133–14010.1016/S0022-2860(02)00642-7 ↗
41. Wang L, Li P, Wang L (2009) Luminescent and hydrophilic LaF3-polymer nanocomposite for DNA detection. Luminescence 24:39–44. doi: 10.1002/bio.106110.1002/bio.1061 ↗
42. Wang Q, You Y, Ludescher RD, Ju Y (2010) Syntheses of optically efficient (La1 xy Ce x Tb y ) F3 nanocrystals via a hydrothermal method. J Lumin 130:1076–1084. doi: 10.1016/j.jlumin.2010.01.02810.1016/j.jlumin.2010.01.028 ↗
43. Wang C, Cheng L, Liu Z (2013) Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics. Theranostics 3(5):317–330. doi: 10.7150/thno.528410.7150/thno.5284 ↗
44. Wangoo N, Suri CR, Shekhawat G (2008) Interaction of gold nanoparticles with protein: a spectroscopic study to monitor protein conformational changes. Appl Phys Lett 92:133104. doi: 10.1063/1.290230210.1063/1.2902302 ↗
45. Xu H, Cheng L, Wang C, Ma X, Li Y, Liu Z (2011) Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomaterials 32:9364–9373. doi: 10.1016/j.biomaterials.2011.08.05310.1016/j.biomaterials.2011.08.053 ↗
46. Yan J, Carmen EM, Smith JE, Wang K, Xiaoxiao H, Wang L, Tan W (2007) Dye doped nanoparticles for bioanalysis. Nano Today 2(3):44–5010.1016/S1748-0132(07)70086-5 ↗
47. Yan-Jun H, Yi L, Xue-Song S, Xian-Yang F, Song-Sheng Q (2005) Studies on the interaction between 1-hexylcarbamoyl-5-Fluorouracil and bovine serum albumin. J Mol Struct 738:143–147. doi: 10.1016/j.molstruc.2004.11.06210.1016/j.molstruc.2004.11.062 ↗
48. Yao M, Joly AG, Chen W (2010) Formation and luminescence phenomena of LaF3:Ce3+ nanoparticles and lanthanide–organic compounds in dimethyl sulfoxide. J Phys Chem C 114:826–831. doi: 10.1021/jp909217310.1021/jp9092173 ↗
49. Yassin AEB, Khalid AM, Mowafy HA, El-Bagory IM, Bayomi MA, Alsarra IA (2010) Optimization of 5-Fluorouracil solid–lipid nanoparticles: a preliminary study to treat colon cancer. Int J Med Sci 7:398–40810.7150/ijms.7.398 ↗
50. Zhang F, Braun GB, Alessia P, Yichi Z, Yifeng S, Daxiang C, Martin M, Dongyuan Z, Stucky GD (2012) Mesoporous multifunctional upconversion luminescent and magnetic “nanorattle” materials for targeted chemotherapy. Nano Lett 12:61–67. doi: 10.1021/nl202949y10.1021/nl202949y ↗