Investigation on raspberry-like magnetic-hollow silica nanospheres and its preliminary application for drug delivery
Source abstract
Abstract
A series of raspberry-like magnetic-hollow silica nanospheres were successfully synthesized via the sol–gel process, which was based on the principle of the electrostatic interaction between negatively charged silica and positively charged polystyrene. The Fe3O4@SiO2 particles as the outer shell were compactly assembled on the surface of PS, and then magnetic-hollow nanospheres were obtained by calcination. Different synthesis conditions including the amount of NH4OH, TEOS, Fe3O4, and the adding time of PS were systematically investigated to discuss the influence of these conditions on the morphology and structure. The prepared magnetic-hollow nanospheres were systematically characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), fourier transform infrared spectrometry, energy-dispersive X-ray analysis, thermogravimetric analysis and nitrogen adsorption–desorption measurement. SEM and TEM images exhibited that the obtained samples with the perfect spherical profile and large cavities structure were well monodisperse and uniform under the optimized condition. Zeta-potential analysis was employed to make clear the formation mechanism of raspberry-like PS@Fe3O4@SiO2 composite nanosphere. Moreover, the drug release of ibuprofen experiment results demonstrated that the magnetic-hollow nanospheres could be used as a drug carrier to slowly release and deliver drugs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Quantum Dots Synthesis And Properties · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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