journal article·2014-03

Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma

Erica Locatelli, Wolfgang Bost, Marc Fournelle, Jordi Llop, Larraitz Gil, Francesca Arena, Vito Lorusso, Mauro Comes Franchini

Journal of Nanoparticle Research· Volume 16· Issue 3
Publisher page

Abstract

Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (32)

Show source-provided references
1. Allen TM, Cullis PR (2004) Drug delivery systems: entering the mainstream. Science 303:1818–182210.1126/science.1095833 ↗
2. Bonini BF, Camaggi CM, Comes Franchini M, Gentili D, Pession A, Rani M, Strocchi E (2010) Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas. Eur J Med Chem 45:2024–203310.1016/j.ejmech.2010.01.014 ↗
3. Bost W, Lemor R, Fournelle M (2012) Comparison of the optoacoustic signal generation efficiency of different nanoparticular contrast agents. Appl Opt 51:8041–804610.1364/AO.51.008041 ↗
4. Chen J, Wang D, Xi J, Au L, Siekkinen A, Warsen A, Li ZY, Zhang H, Xia Y, Li X (2007) Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett 7:1318–132210.1021/nl070345g ↗
5. Chen J, Glaus C, Laforest R, Zhang Q, Yang M, Gidding M, Welch MJ, Xia Y (2010) Gold nanocages as photothermal transducers for cancer treatment. Small 6:811–81710.1002/smll.200902216 ↗
6. Comes Franchini M, Ponti J, Lemor R, Fournelle M, Broggi F, Locatelli E (2010) Polymeric entrapped thiol-coated gold nanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent. J Mater Chem 20:10908–1091210.1039/c0jm02209h ↗
7. Duncan R (2003) The dawning era of polymer therapeutics. Nat Rev Drug Discov 2:347–36010.1038/nrd1088 ↗
8. Gazelle GS, Goldberg SN, Solbiati L, Livraghi T (2000) Tumor ablation with radio-frequency energy. Radiology 217:633–64610.1148/radiology.217.3.r00dc26633 ↗
9. Gentili D, Ori G, Comes Franchini M (2009) Double phase transfer of gold nanorods for surface functionalization and entrapment into PEG-based nanocarriers. Chem Comm 45:5874–587610.1039/b911582j ↗
10. Goldberg SN (2001) Radiofrequency tumor ablation: principles and techniques. Eur J Ultrasound 13:129–14710.1016/S0929-8266(01)00126-4 ↗
11. Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price RE, Hazle JD, Halas NJ, West JL (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 100:13549–1355410.1073/pnas.2232479100 ↗
12. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 95:4607–461210.1073/pnas.95.8.4607 ↗
13. Huang X, El-Sayed IH, Qian W, El-Sayed MA (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128:2115–212010.1021/ja057254a ↗
14. Huang Y, He S, Cao W, Cai K, Liang XJ (2012) Biomedical nanomaterials for imaging-guided cancer therapy. Nanoscale 4:6135–614910.1039/c2nr31715j ↗
15. Huber P, Debus J, Jenne J, Jochle K, van Kaick G, Lorenz WJ, Wannenmacher M (1996) Therapeutic ultrasound in tumor therapy. Principles, applications and new developments. Radiologe 36:64–7110.1007/s001170050041 ↗
16. Jana NR, Gearheart L, Murphy CJ (2001) Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template. Adv Mater 13:1389–139310.1002/1521-4095(200109)13:18<1389::AID-ADMA1389>3.0.CO;2-F ↗
17. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics. CA Cancer J Clin 60:277–30010.3322/caac.20073 ↗
18. Kremkau FW (1979) Cancer therapy with ultrasound: a historical review. J Clin Ultrasound 7:287–30010.1002/jcu.1870070410 ↗
19. Levy-Nissenbaum E, Khan W, Pawar RP, Tabakman R, Naftali E, Winkler I, Kaufman O, Klapper L, Domba AJ (2012) Pharmacokinetic and efficacy study of cisplatin and paclitaxel formulated in a new injectable poly(sebacic-co-ricinoleic acid) polymer. Eur J Pharm Biopharm 82:85–9310.1016/j.ejpb.2012.06.004 ↗
20. Locatelli E, Comes Franchini M (2012) Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system. J Nanopart Res 14:1316–133310.1007/s11051-012-1316-4 ↗
21. Locatelli E, Broggi F, Ponti J, Marmorato P, Lena S, Comes Franchini M (2012) Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma. Adv Healthcare Mater 1:342–34710.1002/adhm.201100047 ↗
22. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C (2008) In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7:1730–173910.1158/1535-7163.MCT-08-0016 ↗
23. Nikoobakht B, El-Sayed MA (2003) Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem Mater 15:1957–196210.1021/cm020732l ↗
24. Oyewumi MO, Yokel RA, Jay M, Coakley T, Mumper RJ (2004) Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. J Control Release 95:613–62610.1016/j.jconrel.2004.01.002 ↗
25. Sato M, Watanabe Y, Ueda S, Iseki S, Abe Y, Sato N, Kimura S, Okubo K, Onji M (1996) Microwave coagulation therapy for hepatocellular carcinoma. Gastroenterology 110:1507–151410.1053/gast.1996.v110.pm8613057 ↗
26. Seo HW, Kim DY, Kwon DY, Kwon JS, Jin LM, Lee B, Kim JH, Min BH, Kim MS (2013) Injectable intratumoral hydrogel as 5-fluorouracil drug depot. Biomaterials 34:2748–275710.1016/j.biomaterials.2013.01.006 ↗
27. Soroceanu L, Gillespie Y, Khazaeli MB, Sontheimer H (1998) Use of chlorotoxin for targeting of primary brain tumors. Cancer Res 58:4871–4879
28. Veiseh O, Veiseh O, Sun C, Gunn J, Kohler N, Gabikian P, Lee D, Bhattarai N, Ellenbogen R, Sze R, Hallahan A, Olson J, Zhang M (2005) Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett 5:1003–100810.1021/nl0502569 ↗
29. Veiseh O, Gunn JW, Kievit FM, Sun C, Fang CH, Lee JS, Zhang M (2009) Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles. Small 5:256–26410.1002/smll.200800646 ↗
30. Wei J, Cheang T, Tang B, Xia H, Xing Z, Chen Z, Fang Y, Chen W, Xu A, Wang S, Luo J (2013) The inhibition of human bladder cancer growth by calcium carbonate/CaIP6 nanocomposite particles delivering AIB1 siRNA. Biomaterials 34:1246–125410.1016/j.biomaterials.2012.09.068 ↗
31. Xie J, Lee S, Chen X (2010) Nanoparticle-based theranostic agents. Adv Drug Deliv Rev 62:1064–107910.1016/j.addr.2010.07.009 ↗
32. Yu MK, Park J, Jon S (2012) Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics 2:310.7150/thno.3463 ↗